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Colposcopy

Colposcopy is the direct magnified inspection of the surface of a womans genital area, including the cervix, vagina, and vulva, using a light source and a binocular microscope - a colposcope. It is used to evaluate potentially cancerous areas, typically after an abnormal cervical smear. A biopsy of an abnormal area may be taken during the procedure. Colposcopy also can be used to detect inflammatory or infectious changes, harmless growths, and assess traumatic injuries to the lower genital tract.

Indications for Referral

Management of Dysplasia (Dyskaryosis) on Cervical Smear

Result

Action

Negative
  • Investigate and manage incidental findings (e.g. infections).
  • Ensure that the patient is informed of the result.
  • Recall as appropriate for a negative result.
Inadequate
  • Repeat sample immediately after treating any infection or atrophy, preferably within 3 months
  • Repeat sample as soon as convenient if technically inadequate
  • If persistent (3 inadequate samples), advise assessment by colposcopy1
Borderline
  • Borderline nuclear change in endocervical cells - refer for colposcopy.

  • Borderline nuclear change in squamous cells

    • Treat any associated condition and repeat the screen at no more than 6 months (particularly important where there
      is an association with HPV).
      The majority of smears will return to normal by this stage.
    • Refer for colposcopy if there are 3 smears in a series reported as borderline nuclear change in squamous cells) without the woman being returned to routine recall, or 3 borderline or more severe results in a 10 year period.
    • Three consecutive negative results, 6 months apart, are required before returning to routine recall.
    • Repeat sample in 3-6 months when the differential diagnosis is between benign/reactive changes and higher
      degrees of dyskaryosis or possible glandular neoplasia.
    • The laboratory may recommend a repeat screening in a shorter interval, or that gynaecological referral should be considered.
Mild Dyskaryosis
  • Ideally, women should be referred for colposcopy after one mild dyskaryotic smear, but it remains acceptable to recommend a repeat test within 6 months - many will have returned to normal by this stage.
  • Always refer for colposcopy after two tests reported as mild dyskaryosis
    without a return to routine recall.
  • If a single mild dyskaryotic result is obtained after treatment for CIN2 or worse, refer for colposcopy.
  • Three consecutive negative results, 6 months apart, are required before returning to routine recall.
  • If in a 10 year period there are 3 borderline or more severe results, refer to colposcopy.
Moderate Dyskaryosis Refer for colposcopy.
Severe Dyskaryosis Refer for colposcopy.
Colposcopy Preparation
  • The patient should not have the examination if they are menstruating.
  • Sexual intercourse, vaginal medications, and tampons should be avoided for 24 hours before the examination.
  • Recommend simple analgesia 1 hour before the procedure. Paracetamol, aspirin or ibuprofen may be used, but NSAIDs may increase bleeding from the procedure due to these drugs' anti-platelet effect.
Procedure

The patient sits in a reclining chair in lithotomy position. A speculum is inserted to visualise the cervix. The cervix is stained with acetic acid in the area of the Transformation Zone (T.Z.)to identify the site, grade and shape of the abnormal area of cells. The solution is applied using a long-handled cotton bud. Abnormal dyskaryotic/dysplastic cells will stain white; generally, the more dense the white area becomes, the higher the grade of abnormality.
A water-based solution of iodine is then gently applied to the rest of the cervix to identify the complete area of abnormality. With iodine, the normal cells stain jet black and the abnormal cells stain yellow.
There is usually good correlation between the abnormality suggested by the cervical smear and the appearances seen through the colposcope.2,3 In cases of doubt a small biopsy can be taken from the worst looking area for analysis. This is carried out using special biopsy forceps which remove a small fragment of tissue with minimal discomfort.
Women who have an obvious abnormality at colposcopy, or who have a positive biopsy result will proceed to treatment. The most common form of treatment in the UK is called LLETZ (Large Loop Excision of the Transformation Zone). Treatment by LLETZ can take place at the end of the colposcopy examination during the same clinic visit, or treatment may be carried out at a later visit.

Risks

The procedure is relatively safe. Most commonly occuring risks include bleeding, infection, and pelvic or abdominal pain. Colposcopy during pregnancy may cause complications with the pregnancy, including early labour.

After the Procedure
  • Following the colposcopy, the patient should wear a sanitary pad.
  • Small amounts of bleeding may occur for 3-5 days.
  • Dark fluidlike material may be seen on the pad, sometimes green, or resembling coffee grounds. The fluid is that used during the exam.
  • The patient should avoid sexual intercourse, vaginal medications, or tampons until the bleeding stops.


Document References
  1. Colposcopy and Programme Management; Guidelines for the NHS Cervical Screening Programme (2004)
  2. Jones MH, Jenkins D, Singer A; Regular audit of colposcopic biopsies from women with a mildly dyskaryotic or borderline cervical smear results in fewer cases of CINIII. Cytopathology. 1996 Feb;7(1):17-24. [abstract]
  3. Errington CA, Roberts M, Tindle P, et al; Colposcopic management of high-grade referral smears: a retrospective audit supporting 'see and treat'? Cytopathology. 2006 Dec;17(6):339-47. [abstract]

Internet and Further Reading Acknowledgements EMIS is grateful to Dr Hayley Willacy for writing this article. The final copy has passed scrutiny by the independent Mentor GP reviewing team. ©EMIS 2007.
DocID: 4177
Document Version: 1
DocRef: bgp26045
Last Updated: 29 Mar 2007
Review Date: 28 Mar 2009




















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