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Pleural Effusion Aspiration

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Synonym: thoracentesis, pleural tap

This article should be read in conjunction with the separate article entitled 'Pleural Effusion'.

Percutaneous pleural effusion aspiration is carried out:

  • To investigate the cause of pleural effusion: the British Thoracic Society guidelines suggest that pleural aspiration should be reserved for the investigation of unilateral exudative pleural effusions. It should not be carried out if a unilateral or bilateral transudative effusion is suspected, unless there are atypical features or failure of response to therapy.1
  • As symptom relief for breathlessness: repeated 'tapping' of fluid may be useful in palliative care. However, there is a high recurrence rate if pleurodesis (intrapleural instillation of a sclerosant) is not carried out simultaneously.2
Relative contraindications to pleural effusion aspiration3
  • Very small volume of fluid
  • Bleeding diathesis
  • Anticoagulant therapy
  • Mechanical ventilation (increased likelihood of tension pneumothorax or bronchopleural fistula if lung is punctured)
  • Cutaneous disease over the proposed skin puncture site
The procedure3,4
  • Can be performed in the clinic or by the bedside.
  • Radiological guidance (e.g. ultrasound) is sometimes needed for smaller effusions.
  • Sit the patient as upright as possible. A pillow can be used to support arms and head on an adjustable table or couch. If the patient leans forward too much it increases the risk of liver/spleen injury.
  • Use an aseptic technique throughout the procedure.
  • Use percussion to determine the upper level of fluid.
  • The conventional site for aspiration is posteriorly, approximately 10cm lateral to the spine (mid-scapular line) and 1-2 intercostal spaces below the upper level of the fluid.
  • Mark the spot and clean the area using antiseptic.
  • Use local anaesthetic (5-10 ml of 1% lidocaine) to infiltrate the skin and underlying tissues. A 25G needle can be used for this.
  • Avoid the intercostal nerves and vessels that run immediately beneath the rib by inserting the needle just above the upper border of the rib below your mark.
  • You can confirm the correct location for pleural aspiration by aspirating a small amount of fluid through this smaller needle.
  • Attach a 21G needle to a 50 ml syringe.
  • Again, avoid the intercostal nerves and vessels by inserting the needle just above the upper border of the rib below your mark. Aspirate while you are advancing the needle.
  • 50-100 ml of fluid is usually adequate for diagnostic purposes.
  • Look at the fluid obtained and note any odour: purulent fluid suggests empyema; milky, opalescent fluid suggests chylothorax; grossly bloody fluid suggests haemothorax; anaerobic infection has a pungent odour.
  • Separate the pleural fluid into different sterile pots to be sent for biochemistry, microbiology, cytology ± immunology. Some fluid should also be added to blood culture bottles.
  • A post-procedure chest X-ray to look for pneumothorax is not generally needed provided the patient is asymptomatic and the procedure was uncomplicated.

If the procedure is being carried out to relieve breathlessness, a greater volume of fluid usually needs to be drained:5

  • Use a 14G intravenous cannula instead of the 21G needle.
  • Administer oxygen and use pulse oximetry throughout the procedure.
  • Follow the same steps as above.
  • When the cannula is inserted, remove the stylet and connect a closed pleural aspiration kit.
  • The fluid should still be sent for analysis.
  • It is best to remove fluid slowly.
  • Monitor for chest pressure or pain during fluid removal. This can be a sign of lung entrapment due to extensive pleural involvement or endobronchial obstruction which will prevent re-expansion of the lung when the fluid is removed. If this occurs, stop the procedure.3
  • Rarely, if more than 1.5 litres of fluid is drained off, fluid shifts can cause haemodynamic instability or pulmonary oedema. The recommended fluid drainage limit is 1-1.5 litres.

A chest drain can also be inserted for pleural fluid drainage.

Investigations to be requested on the pleural fluid

The British Thoracic Society suggest the following initial investigations:

  • Microbiology:
    • Send 1 pot for Gram stain, AAFB stain, microscopy, culture and sensitivity.
    • Send some fluid in blood culture bottles (increases yield, especially for anaerobic organisms).6
  • Biochemistry:
    • Send 1 pot for protein, lactate dehydrogenase (LDH) and pH.
  • Cytology:
    • Send a 20 ml sample in a sterile pot for cytological examination. Some cytologists prefer samples to be sent in a citrate bottle to prevent clots (discuss with your laboratory).
    • Sample needs to be fresh. It can be stored at 4°C for up to 4 days.
    • Malignant effusions can be diagnosed by pleural fluid cytology alone in 60% of cases.1 A second sample can increase diagnostic yield.

Additional investigations should be requested under specific circumstances:1

  • If empyema is suspected send some fluid for centrifuge.
  • If chylothorax is suspected send some fluid for centrifuge, cholesterol and triglyceride levels and investigation for the presence of cholesterol crystals and chylomicrons.
  • If haemothorax is suspected, or the pleural fluid is grossly bloody, send some fluid for haematocrit level.
  • If rheumatoid disease is suspected send some fluid for glucose and complement levels.
  • If pancreatitis is suspected send some fluid for amylase level.
Interpretation of pleural fluid results

The interpretation of pleural fluid results is discussed in the separate article 'Pleural Effusion'.

Complications3
  • Pain during and after procedure at puncture site
  • Pneumothorax (complicates 12-30% of pleural aspirations but chest drain treatment is required in <5% of these)
  • Bleeding (may be cutaneous or internal)
  • Empyema
  • Inadvertent liver/spleen puncture

Document references
  1. Maskell NA, Butland RJ; BTS guidelines for the investigation of a unilateral pleural effusion in adults. Thorax. 2003 May;58 Suppl 2:ii8-17.
  2. Antunes G, Neville E, Duffy J, et al; BTS guidelines for the management of malignant pleural effusions. Thorax. 2003 May;58 Suppl 2:ii29-38.
  3. Rubins J; eMedicine. Pleural Effusion. Last Updated February 15, 2007.
  4. Pleural disease. Chapter 4.36. Oxford Textbook of Medicine 4th edition.
  5. Peek GJ, Morcos S, Cooper G; The pleural cavity. BMJ. 2000 May 13;320(7245):1318-21.
  6. Ferrer A, Osset J, Alegre J, et al; Prospective clinical and microbiological study of pleural effusions. Eur J Clin Microbiol Infect Dis. 1999 Apr;18(4):237-41. [abstract]
Acknowledgements EMIS is grateful to Dr M Preston for writing this article. The final copy has passed scrutiny by the independent Mentor GP reviewing team. ©EMIS 2008.
DocID: 2979
Document Version: 20
DocRef: bgp2409
Last Updated: 19 Feb 2008
Review Date: 18 Feb 2010

The authors and editors of this article are employed to create accurate and up to date content reflecting reliable research evidence, guidance and best clinical practice. They are free from any commercial conflicts of interest. Find out more about updating.

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