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Cannabis Use and Abuse

Synonyms (Street names): Marijuana, hashish, ganja, weed, dope, pot, grass.

Description
  • Cannabis is from the flowering plant Cannabis and is made from the subspecies Cannabis sativa L.
  • Cannabis is a drug that produces euphoria and reduces anxiety.
  • It can cause dependence but addiction as shown by increasing use and inability to discontinue use is uncommon.
  • The drug can be used occasionally without causing significant social or mental problems. Withdrawal may cause anxiety and disturbed sleep in heavy users.
Pathophysiology
  • Cannabis can be smoked or ingested e.g. herbal tea, butterpaste.
  • When cannabis is ingested it results in cannabinoids which results in its psychological and physical affects.
  • The most active of these is tetrahydrocannabinol (THC).
Epidemiology1
  • It is estimated that 4% of the worlds population use cannabis - with rates of up to 10-30% in Europe.
  • The number of cannabis smokers is on the increase.
  • In 2002-2003, of 11% of the British population reported use in the previous year - this was highest in the youngest age group (16-24 year olds).
  • Estimated that 3.2 million people in Britain smoke cannabis.
Presentation
  • Cannabis induces a relaxed state characterised by a series of disconnected thoughts.
  • There may also be:
    Psychological affectsPhysical affects
    • Dry mouth
    • Dry eyes
    • Bloodshot eyes
    • Increased heart rate
  • Effects are prolonged for 2-3 hours after smoking with no clear evidence of hangover or lasting effect
  • Ability to drive and operate machinery is impaired due to effects on motor skills and depth perception
  • Symptoms of schizophrenia may be worsened
Complications

Schizophrenia

  • Cannabis use is associated with an increased risk of schizophrenia symptoms not related to a pre-existing psychosis.2
  • Early cannabis use (<15 years) brings greater risk for schizophrenia than use by 18 years.
  • Risk is specific to cannabis and not other drugs.
  • Although most young people use cannabis without problems, a minority has harmful results 1 in 10 cannabis users by age 15 developed schizophreniform disorder by age 26 compared with 3% of rest.

Dependence

  • For some years the general feeling was that cannabis does not produce dependence.
  • However dependence is common and difficult to treat.3
  • Animals exhibit a withdrawal syndrome and a similar problem is being recognised in humans.4

Respiratory

Regular high dose users develop episodes of acute bronchitis, wheezing and coughing with changes in pulmonary function. These changes in lung function can be long-term. It is unclear whether these effects are related to the concurrent use of tobacco or cocaine or cannabis directly. Furthermore, tobacco smoking and smoking marijuana is associated with increased respiratory illness amongst other symptoms.5

Cognitive function

Some tests have shown a reduction in cognitive function in long-term regular users but this has to be confirmed.6

Use of cannabis in medical treatment

See also Therapeutic Uses of Cannabis.
There have been studies looking at the beneficial effects of cannabis in cancer, AIDS, depression, nausea when using chemotherapy and various neurological diseases e.g. multiple sclerosis.7 However, the efficacy is unclear at present and there are concerns regarding its safety.


Document References
  1. Raphael B, Wooding S, Stevens G, et al; Comorbidity: cannabis and complexity. J Psychiatr Pract. 2005 May;11(3):161-76. [abstract]
  2. Weiser M, Noy S; Interpreting the association between cannabis use and increased risk for schizophrenia.; Dialogues Clin Neurosci. 2005;7(1):81-5. [abstract]
  3. Budney AJ, Moore BA; Development and consequences of cannabis dependence. J Clin Pharmacol. 2002 Nov;42(11 Suppl):28S-33S. [abstract]
  4. Lichtman AH, Martin BR; Cannabinoid tolerance and dependence. Handb Exp Pharmacol. 2005;(168):691-717. [abstract]
  5. Patkar AA, Batra V, Mannelli P, et al; Medical symptoms associated with tobacco smoking with and without marijuana abuse among crack cocaine-dependent patients. Am J Addict. 2005 Jan-Feb;14(1):43-53. [abstract]
  6. Harvey MA, Sellman JD, Porter RJ, et al; The relationship between non-acute adolescent cannabis use and cognition. Drug Alcohol Rev. 2007 May;26(3):309-19. [abstract]
  7. Perras C; Sativex for the management of multiple sclerosis symptoms.; Issues Emerg Health Technol. 2005 Sep;(72):1-4. [abstract]
Acknowledgements EMIS is grateful to Dr Gurvinder Rull for writing this article. The final copy has passed scrutiny by the independent Mentor GP reviewing team. ©EMIS 2007.
DocID: 1902
Document Version: 20
DocRef: bgp2199
Last Updated: 31 Jul 2007
Review Date: 30 Jul 2009


















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See also MAKEPOVERTYHISTORY North East for details and links to campaigns against poverty.

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