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This is a PatientPlus article. PatientPlus articles are written for doctors and so the language can be technical. However, some people find that they add depth to the articles found in the other sections of this website which are written for non-medical people.
Synonyms: Laurence Moon Biedel Syndrome, Laurence-Moon Bardet-Biedel syndrome, Adipogenital-Retinitis Pigmentosa Syndrome, LM syndrome, LMBB syndrome.
This is a rare autosomal recessive condition, whose main features are mental retardation, pigmentary retinopathy, hypogenitalism, and spastic paraplegia.1 It is probably a variant of Bardet-Biedel syndrome without obesity or polydactyly.2 For this reason it is sometimes known as the Laurence-Moon-Biedel Syndrome or the Laurence-Moon-Bardet-Biedel Syndrome.
Features- Short Stature (no obesity)
- Pigmentary retinopathy, nystagmus and choroidal atrophy
- Micropenis with hypoplastic scrotum
- Mental retardation, ataxia with spastic paraplegia
History- John Zachariah Laurence was a British ophthalmologist, born 1829 and died 1870. He was a founder of the South London Ophthalmic Hospital, later known as the Royal Eye Hospital.
- Robert Charles Moon was born in Brighton in 1844 and qualified in London but emigrated to the USA in 1879, having been a surgeon at the South London Ophthalmic Hospital. He worked in Philadelphia and died in 1914.
- Arthur Biedl was an endocrinologist born 1869 in Hungary but qualified in Vienna and later became professor at the Institute of Pathology in Vienna. He died in 1933.
- Georges Louis Bardet was a French physician born 1885. Very little is known about him, not even his date of death.
Document references
- OMIM; Laurence Moon Syndrome, Online Mendelian Inheritance in Man.
- OMIM; Bardet Biedl Syndrome. Online Mendelian Inheritance in Man.
Acknowledgements EMIS is grateful to Dr Huw Thomas for writing this article. The final copy has passed scrutiny by the independent Mentor GP reviewing team. ©EMIS 2008.
DocID: 2374Document Version: 20
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Last Updated: 14 May 2008Review Date: 14 May 2010
The authors and editors of this article are employed to create accurate and up to date content reflecting reliable research evidence, guidance and best clinical practice. They are free from any commercial conflicts of interest. Find out more about updating.
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