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PatientPlus articles are written for doctors and so the language can be technical. However, some people find that they add depth to the articles found in the other sections of this website which are written for non-medical people.

Diabetic Neuropathy

There are separate articles on Managing Diabetes in Primary Care and the Diabetic Foot.

  • Diabetic neuropathy is a common complication of both Type 1 diabetes and Type 2 diabetes. Neuropathy plays a major role in the development of foot ulcers, which cause an enormous burden on quality of life for the patient (especially if amputation becomes necessary) and is also responsible for a very large health and social services expenditure.
  • Optimal control of all metabolic factors and regular organised surveillance of all people with diabetes is essential to reduce the risk of both development and progression of diabetic neuropathy and therefore reduce the risk of disability for the patient.
  • Motor, sensory, and autonomic fibres may all be affected by diabetic neuropathy.
Risk factors
Peripheral sensorimotor (Chronic peripheral neuropathy)
  • Sensory nerves are affected more than motor.
  • Touch, pain and temperature sensation and proprioception in lower limbs in a glove and stocking distribution.
  • Loss of ankle jerks and later knee jerks.
  • Hands are only affected in severe longstanding neuropathy.
  • Equal prevalence in Types 1 and 2.
Acute diffuse painful (acute peripheral neuritis)
  • Often abrupt onset and not related to duration of diabetes.
  • Can resolve completely.
  • Burning foot pain, often worse at night.
  • Associated with poor glycaemic control but sometimes initially follows establishing good glycaemic control.
  • Examination may be normal apart from hyperaesthesia.
Autonomic neuropathy
Mononeuropathy
  • External pressure or entrapment, e.g. carpal tunnel syndrome.
  • Isolated neuropathies of either cranial or peripheral nerves. Mononeuropathies of cranial nerves III, IV, and VI, intercostal nerves, and femoral nerves are common.
  • Occasionally more than one nerve is involved (mononeuritis multiplex).
Proximal motor (diabetic amyotrophy)
  • Main motor manifestation.
  • Severe pain and paraesthesiae in upper legs, with weakness and muscle wasting of thigh and pelvic girdle muscles.
  • May be asymmetrical and there may be extensor plantars.
  • Mainly affects middle-aged and elderly patients.
  • Usually associated with period of very poor glycaemic control, sometimes with dramatic weight loss.
  • Pain and weakness gradually reduce once good glycaemic control has returned.
Presentation

Early features of neuropathy often go unrecognised by the patient, further emphasising the importance of routine surveillance.

Differential diagnosis
Investigations
  • Full assessment of diabetes and blood pressure control. Assessment of other possible causes, e.g. thyroid function tests, B12.
  • May require nerve conduction studies and EMG.
Management
  • Regular surveillance for signs of neuropathy to allow early intervention.
  • Tight glycaemic control.
  • Prevention of foot trauma.

Management of painful neuropathy

  • May require a great deal of support for the depressing and disabling nature of the condition
  • Consider initially:
    • Bed foot cradles for night-time problems
    • Simple analgesia taken in advance of diurnal symptoms
    • Contact dressings
  • Drug treatments:
    • Oral tricyclic antidepressants and traditional anticonvulsants are better for short term pain relief than newer generation anticonvulsants.1
    • Evidence of the long term effects of oral antidepressants and anticonvulsants is still lacking.1
    • Therefore consider therapeutic trials of:1
      • Tricyclic antidepressants (TCAs) and topical capsaicin should be used as first line therapy in painful diabetic neuropathy.1
      • Traditional anticonvulsants (sodium valproate, carbamazepine) should be considered if insufficient symptom control.
      • Newer anticonvulsants (gabapentin, pregabalin) should next be considered if necessary.
      • Duloxetine and then opioids may be required if symptom control is still inadequate.1

Management of autonomic neuropathy

See separate article on autonomic neuropathy. The only treatment for autonomic neuropathy is to treat symptoms. In all patients, optimise diabetic control.

  • Erectile dysfunction: see separate article.
  • Gastroparesis
    • Investigation using radiological or radioisotope methods may help in diagnosis
    • Investigation of cardiovascular autonomic neuropathy may help diagnosis
    • Metoclopramide and domperidone are worth a trial
  • Diabetic nocturnal diarrhoea
    • Investigation must exclude other causes of intestinal upset
    • May be helped by high doses of codeine, loperamide or diphenoxylate, or by erythromycin or tetracycline
  • Gustatory sweating
    • Explanation and counselling are often required
    • Topical or oral anticholinergic agents (eg. poldine methylsulphate) may be effective
  • Postural hypotension
    • May respond to fludrocortisone
Prognosis
  • Autonomic neuropathy is associated with high mortality rate (50% within 3 years) mainly due to renal failure or cardiovascular effects but often no obvious cause.
  • Diabetics are 15-70 times more likely to undergo lower limb amputation than non-diabetics.
Prevention


Document references
  1. Wong MC, Chung JW, Wong TK; Effects of treatments for symptoms of painful diabetic neuropathy: systematic review. BMJ. 2007 Jul 14;335(7610):87. Epub 2007 Jun 11. [abstract]

Internet and further reading Acknowledgements EMIS is grateful to Dr Colin Tidy for writing this article. The final copy has passed scrutiny by the independent Mentor GP reviewing team. ©EMIS 2008.
DocID: 2054
Document Version: 20
DocRef: bgp697
Last Updated: 11 Jan 2008
Review Date: 10 Jan 2010




















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PS - Health and Poverty

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See also MAKEPOVERTYHISTORY North East for details and links to campaigns against poverty.

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