Tolterodine

  • Tolterodine is used to treat the symptoms of an overactive bladder.
  • It can be taken before, after or during a meal. Swallow whole with a drink of water.
  • Keep your regular appointments with your doctor, so your progress can be monitored.

About tolterodine

Type of medicineAntimuscarinic
Used forUrinary frequency, urinary urgency, and urinary incontinence
Also calledDetrusitol®
Detrusitol XL®
Available asTablets
Modified release capsules (tolterodine is released slowly to give an even effect)

Tolterodine is used to treat the symptoms of an overactive bladder. These are: urinary frequency (a need to pass water often), urinary urgency (a need to pass water urgently) and urinary incontinence (a lack of control over passing water). Tolterodine works by reducing the muscle contractions that cause these symptoms.

Before taking tolterodine

Before taking tolterodine make sure your doctor or pharmacist knows:

  • If you are pregnant, trying for a baby or breast-feeding.
  • If you suffer from heart, liver or kidney problems.
  • If you suffer from prostate problems.
  • If you suffer from glaucoma, myasthenia gravis (a muscle weakening disease) or hyperthyroidism.
  • If you suffer from hiatus hernia, reflux oesophagitis (acid reflux or heartburn), or ulcerative colitis (ulceration and inflammation of the colon).
  • If you suffer from paralytic ileus, toxic megacolon or have any other problems with gut motility (movement of waste through the gut).
  • If you have been experiencing difficulty urinating (passing water).
  • If you suffer from problems of your nervous system that affect your blood pressure, bowel or sexual function.
  • If you have ever had an allergic reaction to this or any other medicine.
  • If you are taking any other medicines, including those available to buy without a prescription, herbal or complementary medicines.

How to take tolterodine

  • Take your medication exactly as directed by your doctor.
  • Always read the manufacturer's information leaflet, if possible, before beginning treatment.
  • Tolterodine can be taken before, after or during a meal. Swallow them whole with a drink of water.
  • If you miss a dose, take it as soon as you remember and continue taking it at the usual times. If it is nearly time for your next dose, leave out the missed dose, never take two doses at the same time to make up. If in doubt speak to your pharmacist or doctor.
  • If you have been given the modified release capsule swallow it whole. Do not crush or chew it.
  • Never take more than the prescribed dose. If you suspect that you or someone else has taken an overdose of tolterodine contact your doctor or go to the accident and emergency department of your local hospital at once. Where possible take the container with you, even if empty.
  • This medicine is for you. Never give it to others even if their condition appears to be the same as yours.

Getting the most from your treatment

  • Keep your regular appointments with your doctor, so your progress can be monitored.
  • Do not stop taking tolterodine without speaking to your doctor first.
  • Before taking any 'over-the-counter' medicines, check with your pharmacist which medicines are safe for you to take alongside tolterodine.
  • Before having any kind of treatment, including dental or emergency treatment, tell the doctor, dentist or surgeon you are taking tolterodine.

Can tolterodine cause problems

Along with their useful effects all medicines can cause unwanted side effects, which usually improve as your body adjusts to the new medicine. Speak with your doctor or pharmacist if any of the following side effects continue or become troublesome.

Common side-effects - these affect less than 1 in 10 people who take this medicineWhat can I do if I experience this
Dry mouthTry sucking sugar-free sweets, pieces of ice or chewing sugar-free gum
ConstipationTry to eat a well balanced diet containing plenty of fibre and drink several glasses of water each day
Drowsiness, dizziness or blurred visionMake sure your reactions are normal before driving, operating machinery or doing any other jobs which could be dangerous if you were not fully alert or able to see properly. Avoid alcohol; it will increase any feelings of drowsiness
HeadacheAsk your pharmacist to recommend a suitable pain-killer. If the headache continues, speak with your doctor
Increased sensitivity to sunlightIf your eyes become more sensitive to light than normal, wearing sunglasses or avoiding too much sunlight should help.
If your skin becomes more sensitive to sunlight, avoid sunbeds and bright sunlight or wear a sunscreen of at least factor 15
Reduced ability to sweatMake sure that you do not become overheated in hot weather

Other side effects may include stomach pain, feeling or being sick, dry eyes, difficulty in passing urine, heartburn, wind, tiredness, dry skin or rash, restlessness, feeling disorientated, chest pain, swelling of the ankles and feet, seeing or hearing things that are not real, a fast or fluttering heart beat, and a tingling sensation in the fingers or toes.

Important: if you experience swelling of the mouth or face, or any difficulty in breathing or swallowing, then contact your doctor immediately or go to the accident and emergency department of your local hospital.

How to store tolterodine

  • Keep all medicines out of the reach of children.
  • Store in a cool, dry place, away from direct heat and light.
  • Never keep out of date or unwanted medicines. Take them to your local pharmacy which will dispose of them for you.

Important information about all medicines


  • Keep all medicines out of the sight and reach of children.
  • Make sure that the person prescribing this medicine knows about any other medicines that you are taking. This includes medicines you buy and herbal and homeopathic medicines.
  • If you buy any medicines check with a pharmacist that they are safe to take with your other medicines.
  • Before taking this medicine tell your doctor if you have ever had an allergic reaction after taking any medicine.
  • Never take more than the prescribed dose. If you suspect that you or someone else has taken an overdose of this medicine go to the accident and emergency department of your local hospital at once. Where possible take the container with you, even if it is empty.
  • If you are having any treatment like an operation or dental treatment tell the person carrying out the treatment which medicines you are taking.
  • Always read the printed information leaflet that comes with your medicine.
  • This medicine is for you. Never give it to other people even if their condition appears to be the same as yours.
  • Never keep out of date or unwanted medicines. Take them to your local pharmacy which will dispose of them for you.
  • If you have any questions about this medicine ask your pharmacist.

References

  • British National Formulary; 54th Edition (September 2007) British Medical Association and Royal Pharmaceutical Society of Great Britain, London
  • Manufacturer's PIL, Detrusitol® tablets, Pharmacia Limited, electronic Medicines Compendium. Text revised 30 April 2007, accessed 8 January 2008.
  • Manufacturer's PIL, Detrusitol XL® capsules, Pharmacia Limited, electronic Medicines Compendium. Text revised 30 April 2007, accessed 8 January 2008.
Comprehensive patient resources are available at www.patient.co.uk
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Last Reviewed:
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