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Memantine

  • Memantine is used to treat Alzheimer's disease
  • When starting your treatment your doctor will start off with a small dose and gradually increase the dose
  • The most common side-effects are constipation, headache, dizziness and drowsiness

About memantine

Type of medicineAnti-dementia drugs (glutamatergic modulator)
Used forAlzheimer's disease
Also calledEbixa®
Available asTablets and oral solution

Memantine is used to treat Alzheimer's disease. It cannot cure Alzheimer's disease but it may help with memory loss. It works by blocking the effect of a chemical in the brain that is thought to cause memory disturbances.

Before taking memantine

Before taking memantine make sure your doctor or pharmacist knows:

  • If you are pregnant, trying for a baby or breast-feeding.
  • If you suffer from liver, kidney or heart problems.
  • If you suffer from epilepsy or have ever had convulsions.
  • If you have a history of high and uncontrolled blood pressure.
  • If you have an infection of the bladder or urinary tract.
  • If you are taking other medicines, including those available to buy without a prescription, herbal or complementary medicines.
  • If you have ever had an allergic reaction to this or any other medicine.

How to take memantine

  • Before beginning treatment, read the manufacturer's printed information leaflet.
  • Your caregiver will help you take your medication exactly as directed by your doctor.
  • When starting your treatment your doctor will start off with a small dose and gradually increase the dose. This allows your doctor to make sure that you have the right dose that helps your condition and avoids any unwanted symptoms.
  • Take memantine at the same time each day and try to avoid missing any doses. It can be taken with or without food.
  • If you miss a dose take it a soon as you remember. However, if it is almost time for your next dose, skip the missed dose and take your next dose at the usual time. Never take two doses together to make up.

Getting the most from your treatment

  • It may take several weeks before memantine appears to take effect. You should not stop taking your medication unless directed to do so by your doctor.
  • Keep your regular doctor or clinic appointments so your progress can be assessed.
  • Changes in diet particularly a change from a mixed diet that includes meat and vegetables, to a vegetarian diet may have an effect on treatment with memantine. Talk to your doctor before you make any major changes to your diet.
  • Discuss with your doctor if your illness will allow you to still drive or operate machinery safely.
  • While taking memantine you must avoid getting pregnant. Ask your doctor or pharmacist about suitable contraception if this is relevant to you.

Can memantine cause problems?

Along with their useful effects all medicines can cause unwanted side effects, which usually improve as your body adjusts to the new medicine. Speak with your doctor or pharmacist if any of the following side effects continue or become troublesome.

Common side-effects - these affect less than 1 in 10 people who take this medicineWhat can I do if I experience this
ConstipationTry to eat a well balanced diet containing plenty of fibre and drink 6-8 glasses of water each day. If constipation continues to be a problem speak to your pharmacist or doctor.
HeadacheAsk your pharmacist to recommend a suitable pain-killer. If headache continues speak with your doctor.
Dizziness and/or drowsinessMake sure your reactions are normal before driving, operating machinery or doing any other jobs which could be dangerous if you were not fully alert.
Avoid alcohol; it will increase any feelings of drowsiness
Confusion or tirednessIf you experience these side effects speak with your doctor although they may be as a result of your conditions as well as the medicines you are taking.
Hallucinations and/or fitsIf you experience these side effects speak with your doctor as soon as possible.

How to store memantine

  • Keep all medicines out of the reach and sight of children.
  • Store in a cool, dry place, away from direct heat and light.

Important information about all medicines


  • Keep all medicines out of the sight and reach of children.
  • Make sure that the person prescribing this medicine knows about any other medicines that you are taking. This includes medicines you buy and herbal and homeopathic medicines.
  • If you buy any medicines check with a pharmacist that they are safe to take with your other medicines.
  • Before taking this medicine tell your doctor if you have ever had an allergic reaction after taking any medicine.
  • Never take more than the prescribed dose. If you suspect that you or someone else has taken an overdose of this medicine go to the accident and emergency department of your local hospital at once. Always take the container with you, if possible, even if it is empty.
  • If you are having any treatment like an operation or dental treatment tell the person carrying out the treatment which medicines you are taking.
  • Always read the printed information leaflet that comes with your medicine.
  • This medicine is for you. Never give it to other people even if their condition appears to be the same as yours.
  • Never keep out of date or unwanted medicines. Take them to your local pharmacy which will dispose of them for you.
  • If you have any questions about this medicine ask your pharmacist.

References

Comprehensive patient resources are available at www.patient.co.uk
© EMIS 2011DocID: 1421DocRef: dils3852Last Reviewed: 20 Oct 2008Version: 24
For the planned review period see the Data Creation and Quality Control Process.
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