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Isotretinoin (topical)

  • For external use only.
  • Avoid contact with the eyes, mouth, mucous membranes (e.g. linings of the nose).
  • It can take as long as 6 - 8 weeks for an improvement to be seen.
  • Do not use the gel on sunburnt or broken skin.
  • Avoid exposure to sunlight or sunlamps, or use sun-creams or wear protective clothing.
  • Women should use effective contraception- the progestogen only pill is not effective while using isotretinoin topical.

About isotretinoin (topical)

Type of medicine Retinoid
Used for Mild to moderate acne
Also called Isotrex
Available as Gel

Isotretinoin (topical) works by helping to unblock pores, which allows the skin's natural oil producing glands to function normally.

Before using isotretinoin (topical)

Before using isotretinoin (topical) make sure your doctor or pharmacist knows:

  • If you are pregnant, trying for a baby or breast-feeding.
  • If you suffer from eczema.
  • If you or a family member have suffered from cutaneous epithelioma (a type of skin cancer).

How to use isotretinoin (topical)

  • For external use only.
  • Apply as a thin layer to the affected area.
  • Avoid contact with the eyes, mouth, mucous membranes (eg linings of the nose).
  • Try not to let the gel build up in folds/creases of skin.

Getting the most from your treatment

  • It can take as long as 6 - 8 weeks for an improvement to be seen.
  • Do not use the gel on sunburnt or broken skin.
  • Avoid exposure to sunlight or sunlamps, or use sun-creams or wear protective clothing.
  • Avoid the use of exfoliating cosmetics; if your skin is peeling as a result of this or another type of product, let your skin recover before using isotretinoin topical.
  • Women should use effective contraception- the progestogen only pill is not effective while using isotretinoin topical.

Can isotretinoin (topical) cause problems

Along with their useful effects all medicines can cause unwanted side effects, which usually improve as your body adjusts to the new medicine. Speak with your doctor or pharmacist if any of the following side effects continue or become troublesome.

Common side-effects - these affect less than 1 in 10 people who take this medicine What can I do if I experience this
Stinging, burning or irritation If this continues, speak to your doctor.
Redness and peeling at the site of application Try missing a few doses to see if this lessens.
If redness and peeling return/continue, speak to your doctor.
Change in skin colour This should disappear when you stop using isotretinoin topical.

How to store isotretinoin (topical)

  • Keep all medicines out of the reach of children.
  • Store in a cool, dry place, away from direct heat and light.

Important information about all medicines


  • Keep all medicines out of the sight and reach of children.
  • Make sure that the person prescribing this medicine knows about any other medicines that you are taking. This includes medicines you buy and herbal and homeopathic medicines.
  • If you buy any medicines check with a pharmacist that they are safe to take with your other medicines.
  • Before taking this medicine tell your doctor if you have ever had an allergic reaction after taking any medicine.
  • Never take more than the prescribed dose. If you suspect that you or someone else has taken an overdose of this medicine go to the accident and emergency department of your local hospital at once. Always take the container with you, if possible, even if it is empty.
  • If you are having any treatment like an operation or dental treatment tell the person carrying out the treatment which medicines you are taking.
  • Always read the printed information leaflet that comes with your medicine.
  • This medicine is for you. Never give it to other people even if their condition appears to be the same as yours.
  • Never keep out of date or unwanted medicines. Take them to your local pharmacy which will dispose of them for you.
  • If you have any questions about this medicine ask your pharmacist.
© EMIS 2007 DocID:
3731		 DocRef:
dils3721		 Last Updated:
10 Aug 2007		 Date of Next Review:
9 Aug 2009		 Version:
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PS - Health and Poverty

Perhaps the biggest cause of ill health in the world is poverty. Help to Make Poverty History. For example, why not lend some of your money to disadvantaged communities to enable them to trade their way out of poverty through schemes such as Shared Interest.

See also MAKEPOVERTYHISTORY North East for details and links to campaigns against poverty.

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