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Tretinoin (topical)

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For external use only.
Avoid contact with the eyes, mouth, and the inside of the nostrils.
It can take as long as 6 - 8 weeks for an improvement to be seen.
Do not use on sunburnt or peeling skin.
Avoid exposure to sunlight or sunbeds.
Women should use effective contraception - the progestogen only pill is not effective while using tretinoin.

About tretinoin (topical)

Type of medicine	Retinoid
Used for	Mild to moderate acne
Also called	Retin-A® Aknemycin® Plus (tretinoin with erythromycin)
Available as	Gel (Retin-A®) Solution (Aknemycin® Plus)

About tretinoin (topical)

Tretinoin works by reducing the production of sebum, the oily substance produced by the skin. Sebum can block pores leading to spots, blackheads and inflammation.

Before using tretinoin (topical)

Before using tretinoin topical make sure your doctor or pharmacist knows:

If you are pregnant, trying for a baby or breast-feeding.
If you suffer from eczema or a condition causing inflammation of the skin.
If you, or a family member, have suffered from cutaneous epithelioma (a type of skin cancer).
If you have ever had an allergic reaction to this or any other medicine.

How to use tretinoin (topical)

Before beginning treatment, read the manufacturer's printed information leaflet.
Use this medication exactly as directed by your doctor. It is for for external use only.
Apply tretinoin as a thin layer to the affected area after washing and drying your skin.
Avoid any contact with the eyes, mouth, and mucous membranes (eg linings of the nose).
Try not to let tretinoin build up in the folds or creases of your skin.

Getting the most from your treatment

It can take as long as 6 - 8 weeks for an improvement to be seen.
Do not use on sunburnt or broken skin. Allow any peeling to heal before using tretinoin.
Avoid sunbeds and wear protective clothing in direct sunlight, or use a sun-cream higher than factor 15.
Avoid the use of exfoliating cosmetics; if your skin is peeling as a result of this or another type of product, let your skin recover before using tretinoin.
Women should use effective contraception - the progestogen only pill is not effective while using tretinoin. Ask your doctor or pharmacist for advice.

Can tretinoin (topical) cause problems?

Along with their useful effects all medicines can cause unwanted side effects, which usually improve as your body adjusts to the new medicine. Speak with your doctor or pharmacist if any of the following side effects continue or become troublesome.

Common side-effects	What can I do if I experience this
Stinging, burning or irritation, itching, redness and peeling	Try missing a few doses to see if this lessens. If it is severe or troublesome, speak with your doctor
Change in skin colour	This should disappear when you stop using tretinoin

If you experience any other symptoms which you think may be due to this preparation, speak with your doctor or pharmacist.

How to store tretinoin (topical)

Keep all medicines out of the reach of children.
Store in a cool, dry place, away from direct heat and light.

Important information about all medicines

If you suspect that you or someone else has swallowed some of this medicine, go to the accident and emergency department of your local hospital at once. Take the container with you, even if it is empty.
This preparation is for you. Never give it to other people even if their condition appears to be the same as yours.
Never keep out of date or unwanted medicines. Take them to your local pharmacy which will dispose of them for you.
If you have any questions about this medicine ask your pharmacist.

References

British National Formulary; 54th Edition (September 2007) British Medical Association and Royal Pharmaceutical Society of Great Britain, London (link to current BNF).
Manufacturer's PIL, Retin-A®, Janssen-Cilag Limited, electronic Medicines Compendium. Text approved December 2007, accessed 12 March 2008.

Comprehensive patient resources are available at www.patient.co.uk

DocID:
3730

DocRef:
dils3720

Last Updated:
3 Jun 2008

Date of Next Review:
3 Jun 2010

Version:
22

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