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  • Important: If you are a woman, it is important that you do not become pregnant while you are being treated with adapalene. Your doctor will probably have advised you about using adequate contraceptive methods during your treatment. If at any time during your treatment you think you may be pregnant, stop using adapalene and contact your doctor for advice.
  • Your skin may become more sensitive to sunlight while you are being treated with adapalene. Avoid strong sunlight or use a sun cream higher than factor 15, and avoid using sunbeds.

About adapalene

Type of medicine A retinoid
Used for The treatment of acne
Also called Differin
Available as Cream, gel

Adapalene works by reducing the production of sebum, the oily substance produced by the skin. Sebum can block pores leading to spots, blackheads and inflammation.

Before using adapalene

Before using adapalene make sure your doctor or pharmacist knows:

  • If you are pregnant, trying for a baby or breast-feeding.
  • If you have ever had an allergic reaction to this or any other medicine.
  • If you suffer from eczema.
  • If you or a close relative have, or have ever had a cutaneous epithelioma (a skin tumour).
  • If you are taking any other medicines, including those available to buy without a prescription, herbal and complementary medicines.

How to use adapalene

  • Use this preparation exactly as directed by your doctor.
  • Always read the manufacturer's information leaflet, if possible, before beginning treatment.
  • Apply adapalene thinly to the affected area(s) as directed. It is usually applied once a day, at bedtime.
  • Never use more than the prescribed dose. Using too much of this preparation or using it more often than you have been told will increase your chances of experiencing side effects.
  • Adapalene is for you. Never give it to others, even if their condition appears to be the same as yours.

Getting the most from your treatment

  • Adapalene is best applied after washing and drying your skin. Remember to wash your hands after you have finished applying it.
  • Do not use any harsh soaps or exfoliants while you are being treated with adapalene.
  • Adapalene should not be used on broken, sunburnt or infected skin.
  • Do not allow this preparation to come into contact with the mucous membranes (e.g. mouth, vagina, inside of nose etc.).
  • Avoid contact with the eyes, if any of this preparation gets into the eyes rinse thoroughly with warm water.
  • You may notice a slight change of colour of the skin you are applying this preparation to. This is only temporary and should return to normal soon after finishing treatment with adapalene.
  • Continue using adapalene until no new acne spots appear. You may need to use it for several months.
  • Adapalene is intended for external use only. If you suspect someone has swallowed any, contact your doctor or go to the accident and emergency department of your local hospital. Where possible, take the container with you even if it is empty.
  • Before using any 'over-the-counter' medicines, check with your pharmacist which medicines are safe for you to use alongside adapalene.

Can adapalene cause problems

Along with their useful effects all medicines can cause unwanted side effects, which usually improve as your body adjusts to the new medicine. Speak with your doctor or pharmacist if any of the following side effects continue or become troublesome.

Common side-effects - these affect less than 1 in 10 people who take this medicine What can I do if I experience this
Skin irritation, redness, burning, stinging, itching, dry or peeling skin This usually improves with time. Applying a thinner layer of adapalene may help initially

If your skin becomes very sensitive or sore, stop using the adapalene and tell your doctor. You may be advised to stop using it for a while or to use it less often.

How to store adapalene

  • Keep all medicines out of the reach of children.
  • Store in a cool, dry place, away from direct heat and light.
  • Never keep out of date or unwanted medicines. Take them to your local pharmacy which will dispose of them for you.

Important information about all medicines


  • If you buy any medicines check with a pharmacist that they are safe to take with your other medicines.
  • If you are having any treatment like an operation or dental treatment tell the person carrying out the treatment which medicines you are taking.
  • If you have any questions about this medicine ask your pharmacist.
© EMIS 2007 DocID:
3729
DocRef:
dils3719
Last Updated:
20 Aug 2007
Date of Next Review:
19 Aug 2009
Version:
22

The authors and editors of this article are employed to create accurate and up to date content reflecting reliable research evidence, guidance and best clinical practice. They are free from any commercial conflicts of interest. Find out more about updating.

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