Esomeprazole

  • Esomeprazole reduces the amount of acid produced in the stomach.
  • The most common side-effects are digestive system discomfort (feeling sick, stomach ache, diarrhoea) and headache. These effects are generally mild and do not last long.

About esomeprazole

Type of medicineProton pump inhibitor
Used forGastro-oesophageal reflux disease
Zollinger-Ellison syndrome
Eradication of Helicobacter pylori
To treat or prevent ulcers caused by non-steroidal anti-inflammatory drugs (NSAIDs)
Also calledNexium®
Available asTablets, sachets of granules for an oral suspension, and injection

Esomeprazole works by decreasing the production of acid in the stomach, which helps to reduce acid indigestion and heal ulcers.

Acid is produced naturally in your stomach to help you digest food and to kill bacteria. In some people there may be a problem with the muscular band at the top of the stomach that keeps the stomach tightly closed. This may allow the acid to escape and irritate the oesophagus. This is called 'acid reflux' and can cause heartburn and/or oesophagitis.

Proton pump inhibitors such as esomeprazole stop cells in the lining of the stomach from producing too much acid. By decreasing the amount of acid, they help to reduce acid reflux related symptoms such as heartburn.

Esomeprazole is also used to treat irritation and ulceration of the stomach caused by non-steroidal anti-inflammatory drugs (NSAIDs). It can also be used as one part of a treatment to get rid of Helicobacter pylori, a bacterium found in the stomach which can cause ulcers.

Esomeprazole is also available as a combination preparation with the anti-inflammatory medicine naproxen. For more information about this, see the "Naproxen" information leaflet.

Before taking esomeprazole

Before taking esomeprazole make sure your doctor or pharmacist knows:

  • If you are pregnant, trying for a baby or breast-feeding.
  • If you have kidney or liver problems.
  • If you have any of the following symptoms: bleeding, difficulty swallowing, being sick frequently, or unexplained weight loss.
  • If you are taking other medicines, including those available to buy without a prescription, herbal and complementary medicines.
  • If you have ever had an allergic reaction to this or any other medicine.

How to take esomeprazole

  • Before starting this treatment, read the manufacturer's printed information leaflet from inside the pack.
  • Take esomeprazole exactly as your doctor has told you.
  • Try to take esomeprazole at the same times each day to avoid missing any doses. The usual dose is once a day. However, if you are taking esomeprazole for Helicobacter pylori eradication or if you have Zollinger-Ellison syndrome, you will be asked to take two doses a day - one in the morning and one in the evening.
  • You may take esomeprazole before or after food, although taking it after a meal may slightly delay it taking effect.
  • Do not chew or crush esomeprazole. Swallow the tablets whole with a drink of water, or alternatively, you may disperse your tablet in water before taking it.
  • If you have been given the sachets, mix the content of each sachet with 15 ml of water, stir the liquid and then leave it to thicken for a minute or so. After a few minutes, stir the liquid again and then swallow it. Do not chew the granules as you swallow. (Make sure you take the dose within 30 minutes of first mixing in the water.)
  • If you forget to take a dose, take it as soon as you remember unless it is nearly time for your next dose, in which case leave out the missed dose. Do not take two doses together to make up for a forgotten dose.

Getting the most from your treatment

  • Smoking increases the amount of acid produced by the stomach and will aggravate your condition. If you smoke, talk to your doctor or pharmacist about quitting.
  • Try to avoid foods and drinks that may upset your stomach such as alcohol, citrus fruits/juices, drinks containing caffeine, tomatoes and spicy food.
  • Try to keep your regular appointments with your doctor. This is so your progress can be monitored.
  • If you are having an operation or dental treatment, tell the person carrying out the treatment that you are taking esomeprazole.
  • If you buy any medicines, check with a pharmacist that they are safe to take with esomeprazole.

Can esomeprazole cause problems?

Along with their useful effects, most medicines can cause unwanted side-effects although not everyone experiences them. These usually improve as your body adjusts to the new medicine, but speak with your doctor or pharmacist if any of the following side-effects continue or become troublesome.

Common side-effects - these affect less than 1 in 10 people who take this medicineWhat can I do if I experience this
HeadacheAsk your pharmacist to recommend a suitable painkiller. If the headache continues, speak with your doctor
ConstipationTry to eat a well balanced diet containing plenty of fibre and drink 6-8 glasses of water each day
DiarrhoeaDrink plenty of water to replace any lost fluids
Feeling or being sick, stomach ache, flatulenceEat little and often. Stick to simple or bland foods

If you experience any other symptoms which you think may be due to this medicine, speak with your doctor or pharmacist.

How to store esomeprazole

  • Keep all medicines out of the reach and sight of children.
  • Store in a cool, dry place, away from direct heat and light.

Important information about all medicines


  • Never take more than the prescribed dose. If you suspect that you or someone else has taken an overdose of this medicine go to the accident and emergency department of your local hospital at once. Take the container with you, even if it is empty.
  • This medicine is for you. Never give it to other people even if their condition appears to be the same as yours.
  • Never keep out of date or unwanted medicines. Take them to your local pharmacy which will dispose of them for you.
  • If you have any questions about this medicine ask your pharmacist.

References

Comprehensive patient resources are available at www.patient.co.uk
© EMIS 2011DocID: 1415DocRef: dils3706Last Reviewed: 19 Oct 2011Version: 24
For the planned review period see the Data Creation and Quality Control Process.
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