Mirtazapine

About mirtazapine

Noradrenaline and serotonin are chemicals in the brain which, when released, act to improve mood. Depression is thought to involve a decrease in the amount of these chemicals. Mirtazapine works in the brain to increase the amount of noradrenaline and serotonin in order to lift mood and help relieve depression.

Before taking mirtazapine

Before taking mirtazapine make sure your doctor or pharmacist knows:

• If you suffer from liver, heart or kidney problems.
• If you suffer from epilepsy, hypotension (low blood pressure), glaucoma or diabetes.
• If you have been experiencing difficulty passing urine.
• If you have a history of psychiatric disorders such as schizophrenia or manic depression.
• If you have an intolerance to sucrose or have a condition called phenylketonuria.
• If you are pregnant, trying for a baby or breast-feeding.

Mirtazapine is not usually used in children and adolescents under 18 years

How to take mirtazapine

• Try to take mirtazapine at the same times each day, to avoid missing any doses. It is usually taken at bedtime.
• Tablets should be swallowed whole, not chewed or crushed, with a glass of water.
• Orodispersible (melt-in-the-mouth) tablets should be removed carefully from the packaging by peeling off the foil then placed on the tongue where they will dissolve and then be swallowed without water.
• Do not stop taking mirtazapine without speaking to your doctor first.

Getting the most from your treatment

• It may take two to four weeks before you start to feel better.
• You must keep your regular appointments with your doctor to monitor your progress and you may have to undergo tests to ensure the dose you are taking is right for you.
• Mirtazapine can cause drowsiness. Make sure your reactions are normal before driving, operating machinery or doing any other jobs which could be dangerous if you were not fully alert.
• Try to avoid alcohol as it will increase drowsiness. If you do drink alcohol, drink only in moderation and be aware of its effects on you.
• You may experience light-headedness or dizziness when getting up from a sitting or lying position. Getting up slowly should help, but if it becomes a problem speak with your doctor.
• Mirtazapine should usually be stopped gradually over a few weeks to avoid withdrawal symptoms which may include dizziness, anxiety, headache, nausea, vomiting and agitation

Can mirtazapine cause problems?

Along with their useful effects all medicines can cause unwanted side effects, which usually improve as your body adjusts to the new medicine. Speak with your doctor or pharmacist if any of the following side effects continue or become troublesome.

How to store mirtazapine

• Keep all medicines out of the reach of children.
• Store in a cool, dry place, away from direct heat and light.

Important information about all medicines