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Co-amilozide

  • Co-amilozide is known as a water tablet and will make you pass more water.
  • Take your dose in the morning or during the day.

About co-amilozide

Type of medicine Diuretic
Used for Oedema (water retention)
Hypertension (high blood pressure)
Congestive heart failure
Also called Moduret 25®, Moduretic®
Available as Tablets

Co-amilozide contains two ingredients, hydrochlorothiazide and amiloride which are both diuretics. Co-amilozide may also be referred to as a water tablet. Amiloride is known as a potassium-sparing diuretic because, unlike hydrochlorothiazide, it does not cause your body to lose potassium. These two diuretics work in combination together.

Co-amilozide is used to treat oedema (water retention), often caused by conditions such as liver disease, kidney problems or heart failure. Oedema occurs when fluid leaks out of blood vessels causing swelling in the tissues of the lungs, feet or ankles. Co-amilozide prevents the build up of fluid in the body by increasing the amount of urine produced by the kidneys.

Before taking co-amilozide

Before taking co-amilozide make sure your doctor or pharmacist knows:

  • If you are pregnant, trying for a baby or breast-feeding.
  • If you suffer from liver or kidney problems.
  • If you suffer from Addison's disease (a disorder of the adrenal glands), diabetes, gout, or systemic lupus erythematosus (SLE).
  • If you are taking other medicines, including those available to buy without a prescription, herbal or complementary medicines.
  • If you have ever had an allergic reaction to this or any other medicine.

How to take co-amilozide

  • Before beginning treatment, read the manufacturer's printed information leaflet.
  • Take your medication exactly as directed by your doctor.
  • Co-amilozide will make you urinate (pass water) more often, so your doctor will usually advise you to take your dose in the morning so as not to disturb your sleep. If you take more than one dose per day, take the last dose before 6pm in the evening.
  • If you miss a dose of co-amilozide take it as soon as you remember. However if it is after 6pm in the evening, skip the missed dose and continue taking co-amilozide at the usual times. Do not take two doses together to make up.

Getting the most from your treatment

  • Keep your regular doctor's appointment so your progress can be monitored.
  • It is important to take co-amilozide exactly as your doctor has instructed and to not stop taking it without speaking to your doctor first, even if you feel quite well.
  • Diuretics help you to lose water. On occasions you may lose too much and become dehydrated, leaving you feeling thirsty and your skin looking and feeling dry. Let your doctor know if this happens.

Can co-amilozide cause problems?

Along with their useful effects all medicines can cause unwanted side effects, which usually improve as your body adjusts to the new medicine. Speak with your doctor or pharmacist if any of the following side effects continue or become troublesome.

Common side-effects - these affect less than 1 in 10 people who take this medicine What can I do if I experience this
Stomach upset, stomach ache or cramp Eat little and often and stick to simple foods. Drink water to replace any lost fluids
Dry mouth Try chewing sugar-free gum or sweets, or sucking pieces of ice
Dizziness or feeling faint especially when getting up from sitting or lying down Getting up slowly should help. If you begin to feel dizzy, lie down so that you do not faint, then sit for a few minutes before standing
Feeling tired or drowsy Make sure your reactions are normal before driving, operating machinery, or doing any other jobs that could be dangerous if you were not fully alert
Skin rash, feeling sleepy or confused, headache, aches and pains, muscle cramps, weakness, diarrhoea or constipation If troublesome, tell your doctor

If you experience any other symptoms which you think may be due to this medicine, speak with your doctor or pharmacist.

How to store co-amilozide

  • Keep all medicines out of the reach of children.
  • Store in a cool, dry place, away from direct heat and light.

Important information about all medicines


  • If you are having any treatment like an operation or dental treatment, tell the person carrying out the treatment which medicines you are taking.
  • Never take more than the prescribed dose. If you suspect that you or someone else has taken an overdose of this medicine, go to the accident and emergency department of your local hospital at once. Take the container with you, even if it is empty.
  • This medicine is for you. Never give it to other people even if their condition appears to be the same as yours.
  • Never keep out of date or unwanted medicines. Take them to your local pharmacy which will dispose of them for you.
  • If you have any questions about this medicine ask your pharmacist.

References

  • Manufacturer's PIL, Moduretic®, Bristol-Myers Squibb Pharmaceuticals Ltd, electronic Medicines Compendium. Approved March 2008, accessed 26 June 2008.
  • British National Formulary; 55th Edition (March 2008) British Medical Association and Royal Pharmaceutical Society of Great Britain, London (link to current BNF).
Comprehensive patient resources are available at www.patient.co.uk
© EMIS 2008 DocID:
3543
DocRef:
dils2942
Last Updated:
14 Sep 2008
Date of Next Review:
14 Sep 2010
Version:
22
Patient UK Current Health News
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Perhaps the biggest cause of ill health in the world is poverty. Help to Make Poverty History. For example, why not lend some of your money to disadvantaged communities to enable them to trade their way out of poverty through schemes such as Shared Interest.

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