Lofepramine

About lofepramine

Lofepramine works by increasing the level of naturally occuring chemicals (noradrenaline and serotonin) which help with nerve transmission in the brain. Lofepramine cannot alter the circumstances that may have caused your depression but may improve symptoms such as low mood, poor sleep and poor concentration and in turn allow you to function normally and cope better with any difficult circumstances.

Before taking lofepramine

Before taking lofepramine make sure your doctor or pharmacist knows:

• If you are pregnant, trying for a baby or breast-feeding.
• If you suffer from heart problems.
• If you suffer from liver problems.
• If you suffer from kidney problems.
• If you suffer from thyroid problems.
• If you suffer from epilepsy.
• If you suffer from low blood pressure (hypotension).
• If you suffer from phaeochromocytoma (a growth on the adrenal glands).
• If you suffer from glaucoma (an eye condition).
• If you are experiencing or have ever experienced difficulty urinating (passing water).
• If you suffer from psychosis.
• If you suffer from porphyria (a blood disorder).
• If you have recently had or are still having electroconvulsive therapy.
• If you are prone to dizziness or fainting, particularly when getting up from a lying or sitting position.

How to take lofepramine

• It can take 2 - 4 weeks before you get the full benefit from lofepramine; although you may feel some improvement before this time. So, don't give up on them too soon.
• Stopping treatment suddenly can cause problems and your doctor will probably want to reduce your dose gradually if this is necessary. A normal course lasts up to six months or more after symptoms have eased. So, do not stop them when symptoms go, as they may quickly return.

Getting the most from your treatment

• Regular exercise such as a daily brisk walk, jog or swim is thought to ease symptoms of depression. This is because any exercise releases endorphins that occur naturally in the body helping to improve mood.
• Talking through feelings may help with depression. A friend or relative may help with this, but your GP may suggest a local self-help group, or refer you to a counsellor.
• Antidepressants are not tranquillisers and are not usually addictive.
• There are several types of antidepressant. They can differ in their possible side-effects. If the first one does not suit, another can usually be found that will be fine.
• St John's Wort is a popular herbal medicine that you can buy from pharmacies without a prescription. It sometimes reacts with other medicines, and you should not take it at the same time as antidepressants. Ask your pharmacist or doctor for advice.

Can lofepramine cause problems

Along with their useful effects all medicines can cause unwanted side effects, which usually improve as your body adjusts to the new medicine. Speak with your doctor or pharmacist if any of the following side effects continue or become troublesome.

How to store lofepramine

• Keep all medicines out of the reach of children.
• Store in a cool, dry place, away from direct heat and light.

Important information about all medicines