Amiloride & Cyclopenthiazide

About Amiloride & Cyclopenthiazide

This belongs to the group of medicines known as diuretics.

Diuretics are often referred to as water tablets. This medicine contains two ingredients, Amiloride and Cyclopenthiazide.

This medicine is known as a potassium-sparing diuretic because, unlike some other diuretics, it does not cause your body to lose potassium.

This medicine is used to treat hypertension (high blood pressure).

This medicine is available in tablet form.

It is also sometimes known as: Navispare. You may notice the use of any of these names on the packaging of your medicine.

Before Taking Amiloride & Cyclopenthiazide

Before taking any of this medicine make sure your doctor or pharmacist knows:

• if you are pregnant, trying for a baby or breast-feeding
• if you suffer from liver or kidney problems
• if you suffer from Addison's disease, diabetes, gout (pain and stiffness in the joints), porphyria or systemic lupus erythematosus (SLE)
• if you suffer from prostate problems or have problems urinating (passing water)
• if you suffer from hyperkalaemia (high blood potassium) or any other electrolyte (salt) imbalance in the blood, such as sodium, calcium or magnesium
• if you have ever had an allergic reaction to this or any other medicine
• if you are taking any other medicines, including those available to buy without a prescription, herbal and complementary medicines

How to Take Amiloride & Cyclopenthiazide

• Always read the manufacturer's information leaflet, if possible, before beginning treatment.
• Take this medicine exactly as directed by your doctor.
• This medicine will make you urinate (pass water) more often, so your doctor or pharmacist will usually advise you to take your dose in the morning so as not to disturb your sleep. If you take more than one dose per day, take the last dose before 6pm in the evening.
• If you miss a dose, take it as soon as you remember. However, if it is after 6pm in the evening skip the missed dose and continue taking it at the usual times. Never take two doses at the same time.
• This medicine is for you. Never give it to others, even if their condition appears to be the same as yours.
• Never take more than the prescribed dose. If you suspect that you or someone else has taken an overdose of this medicine contact your doctor or go to the accident and emergency department of your local hospital at once. Always take the container with you, if possible, even if it is empty.

Getting the most from your treatment

• Keep your regular appointments with your doctor so that your progress can be monitored. Your doctor may suggest that you have annual blood tests to check your levels of sodium and potassium.
• Before taking any 'over-the-counter' medicines, check with your pharmacist which medicines are safe for you to take alongside this medicine.
• Avoid excessive consumption of alcohol. Too much alcohol can cause a big drop in blood pressure and may lead to fainting.
• Many patients with high blood pressure do not feel unwell, but untreated it can harm the heart and arteries and damage blood vessels resulting in a heart attack, stroke, heart failure or kidney failure.
• It is very important to take this medicine exactly as your doctor has instructed and not to stop taking it without speaking to your doctor first, even if you feel quite well.
• It is important to follow any dietary advice that you have been given by your doctor. If you are overweight, your doctor may want you to follow a weight reducing diet.
• A diet rich in potassium should be avoided whilst taking this medicine. Salt substitutes contain potassium. Do not use them while taking this medicine unless instructed to do so by your doctor. Too much potassium can be harmful. Your doctor or pharmacist will be able to advise you on your diet.
• Diuretics help you to lose water. On occasions you may lose too much and become dehydrated, leaving you feeling thirsty and your skin looking and feeling dry.
• This medicine can cause dry mouth. If you experience this try chewing sugar-free gum, sucking sugar-free sweets or pieces of ice. If dry mouth becomes too troublesome, discuss the problem with your doctor or pharmacist.
• This medicine may cause you to feel faint or dizzy when getting up from a lying or sitting position. Getting up slowly should help. If this becomes too troublesome ask your doctor for advice.
• Before having any kind of treatment, including dental or emergency treatment, tell the surgeon, dentist or doctor that you are taking this medicine.
• If you have diabetes this medicine may affect your blood sugar levels. Test your urine or blood regularly and report any extreme changes to your doctor.
• This medicine may cause your skin to become more sensitive to sunlight than it is usually. Try to avoid bright sunlight and sunbeds or use a sun cream higher than factor 15 until you know how your skin reacts.

Can Amiloride & Cyclopenthiazide cause problems?

As well as their useful effects all medicines can cause unwanted side effects. Speak to your doctor or pharmacist if any of the following side effects continue or become troublesome.

Tummy upset, dry mouth, skin rashes, confusion, light-headedness, muscle cramps, headache, dizziness, problems sleeping, depression, pins and needles, loss of appetite, feeling or being sick, diarrhoea or constipation.

This medicine can occasionally cause you to lose too much sodium from the body, which is essential for good health.

Severe sickness and diarrhoea may increase your chances of sodium loss. If you experience this contact your doctor or pharmacist as soon as possible.

Signs of excessive sodium loss are confusion, convulsions (fits), difficulty concentrating, irritability, muscle cramps and unusual tiredness or weakness.

If you think you may be suffering from a lack of sodium or if you experience any other worrying symptoms, which you think may be due to this medicine, discuss them with your doctor or pharmacist.

How to store Amiloride & Cyclopenthiazide

• Keep out of reach of children.
• Store in a cool, dry place, away from direct light and heat.
• Never keep out of date or unwanted medicines. Discard them safely out of the reach of children or take them to your local pharmacist who will dispose of unwanted medicines for you.

© EMIS and Cegedim Pharmacy Services Ltd 2005   Updated: 01/02/2005