Nortriptyline

About nortriptyline

Nortriptyline works by preventing certain chemicals (serotonin and noradrenaline) from being reabsorbed back into the nerve cells in the brain. This helps prolong the mood lightening effect of these chemicals, and so helps relieve depression.

In addition, nortriptyline blocks certain receptors in the wall of the bladder, and prevents a chemical (acetylcholine) from acting on these receptors. Acetylcholine normally causes the bladder to empty, so by stopping this action, nortriptyline reduces the need to pass urine.

Before taking nortriptyline

Before taking nortriptyline make sure your doctor or pharmacist knows:

• If you are pregnant, trying for a baby or breast-feeding.
• If you take medication for thyroid problems.
• If you have recently suffered a heart attack, or have heart problems.
• If you suffer from mood swings.
• If you receive electroconvulsive therapy (ECT).
• If you have liver problems.
• If you have phaeochromocytoma (a growth on the adrenal glands).
• If you have porphyria (a rare blood disorder).
• If you have epilepsy.
• If you have experienced difficulty passing water, or had prostate trouble.
• If you have glaucoma (increased pressure in the eye).
• If you are taking other medicines, including those available to buy without a prescription, herbal or complementary medicines.
• If you have ever had an allergic reaction to this or any other medicine.

How to take nortriptyline

• Before beginning treatment, read the manufacturer's printed information leaflet.
• Take your medication exactly as directed by your doctor. Swallow the tablets with a drink of water.
• When used to treat depression, the starting dose is usually low, and increased gradually as your body gets used to the medicine.
• When used for night-time bedwetting, take the dose 30 minutes before bedtime. This treatment can be used for up to 3 months only.
• Try to take nortriptyline at the same times each day to avoid missing any doses.
• If you forget to take a dose, take one as soon as you remember unless it is nearly time for your next dose. Do not take two doses at the same time to make up. If in doubt, speak to your pharmacist or doctor.

Getting the most from your treatment

• Keep your regular doctor's appointment so your progress can be monitored.
• Do not stop taking this medicine without speaking to your doctor first, even if you feel better. Your doctor will want to reduce your dose slowly as stopping suddenly can cause problems.
• Alcohol will increase any feelings of drowsiness caused by taking nortriptyline. It is best to avoid drinking alcohol while you are taking this medicine.
• If you are diabetic, you may need to monitor your blood glucose levels more frequently. Your doctor will be able to advise you about this.
• If you buy any medicines, check with a pharmacist that they are safe to take with your other medicines.

Can nortriptyline cause problems?

Along with their useful effects all medicines can cause unwanted side effects, which usually improve as your body adjusts to the new medicine. Speak with your doctor or pharmacist if any of the following side effects continue or become troublesome.

How to store nortriptyline

• Keep all medicines out of the reach of children.
• Store in a cool, dry place, away from direct heat and light.

Important information about all medicines