Naproxen and Misoprostol

About naproxen and misoprostol

Naproxen and Misoprostol works in two different ways.
Naproxen is a non-steroidal anti-inflammatory drug which works by blocking the action of a substance in the body called cyclo-oxygenase (COX) therefore relieving pain and inflammation. One of the side effects of naproxen is that it can irritate the lining of the stomach.
Misoprostol is a prostaglandin analogue. It copies the action of prostaglandins that live in the stomach and protects the stomach from the irritating effects of naproxen.

Before taking naproxen and misoprostol

Before taking naproxen and misoprostol make sure your doctor or pharmacist knows:

• If you are pregnant, trying for a baby or breast-feeding.
• If you have a history of stomach problems including stomach ulcers.
• If you have a history of allergic disorders.
• If you have ever had an allergic reaction to any other NSAID (eg ibuprofen, diclofenac).
• If you suffer from heart failure.
• If you suffer from asthma.
• If you suffer from liver or kidney problems.
• If you have high or low blood pressure.
• If you suffer from any blood disorders.
• If you suffer from a connective tissue disorder (a disease affecting the connective tissues of the body; a connective tissue is any type of biological tissue that supports and protects organs).
• If you have a rare hereditary problem (galactose intolerance, the Lapp lactase deficiency or glucose-galactose malabsorption).

How to take naproxen and misoprostol

• Take your tablets with or after food.
• Each box of Napratec OP® contains two types of tablet, one type contains naproxen the other contains misoprostol.
• Take one of each tablet together, as directed by your doctor, usually twice a day.
• Make sure that the person prescribing this medicine knows about any other medicines that you are taking. This includes medicines you buy and herbal and homeopathic medicines.

Getting the most from your treatment

• Naproxen may make your skin more sensitive to sunlight. Use a sun cream with sun protection factor 15 or more to protect your skin. Avoid strong sunlight and sunbeds.
• If diarrhoea is troublesome, speak to your doctor who may reduce the dose or stop treatment. Avoid indigestion remedies containing magnesium.
• It is important that you do not get pregnant while taking these tablets. Speak to your doctor or pharmacist for advice on suitable contraception.

Can naproxen and misoprostol cause problems

Along with their useful effects all medicines can cause unwanted side effects, which usually improve as your body adjusts to the new medicine. Speak with your doctor or pharmacist if any of the following side effects continue or become troublesome.

• Any sign of bleeding in the stomach or intestine, for example passing black bowel movements.
• A sudden attack of wheezing or shortness of breath.
• Blistering or peeling of the skin.
• Swelling of the face or throat.
• Yellowing of your skin and the whites of your eyes (jaundice).
• A constantly sore throat or high temperature.

How to store naproxen and misoprostol

• Keep all medicines out of the reach of children.
• Store in a cool, dry place, away from direct heat and light.

Important information about all medicines