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Melphalan
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About melphalan
| Type of medicine | Cytotoxic |
| Used for | Various types of cancer including multiple myeloma, advanced ovarian or breast cancer Polycythaemia vera (increase in number of red cells) |
| Also called | Alkeran |
| Available as | Tablets Injection |
Melphalan works by stopping cancer cells from multiplying. It does this by binding to and damaging the DNA in the cancer cells. This stops the cells from growing and multiplying.
Before taking melphalan
Before taking melphalan make sure your doctor or pharmacist knows:
- If you are pregnant, trying for a baby or breast-feeding.
- If you suffer from kidney problems.
- If you are male and you and your partner are trying for a baby or intend to have children in the future.
How to take melphalan
- Swallow melphalan whole (do not break or crush) half to one hour before food, with a glass of water.
- If you are sick shortly after taking a dose, or you forget a dose, check with your doctor. You will be told whether to take the dose again, or wait until the next dose is due.
Getting the most from your treatment
- While you are taking melphalan, and for a while after you stop treatment, do not have any immunisations (vaccinations) without talking to your doctor first. Melphalan lowers the body's resistance and there is a chance that you may get an infection from a vaccine.
- You must keep your regular appointments with the doctor or hospital so your progress can be checked. You will need to have regular blood tests during your treatment with melphalan.
Can melphalan cause problems
Along with their useful effects all medicines can cause unwanted side effects, which usually improve as your body adjusts to the new medicine. Speak with your doctor or pharmacist if any of the following side effects continue or become troublesome.
| Common side-effects - these affect less than 1 in 10 people who take this medicine | What can I do if I experience this |
| Nausea, vomiting, mouth ulcers | You may be able to buy an over-the-counter remedy; ask your pharmacist for advice |
| Itching, rash | You may be able to buy an over-the-counter remedy; ask your pharmacist for advice |
| Raised temperature, cough, sore throat | See your doctor as soon as possible |
| Hair loss | This is not permanent- speak to your doctor if you are worried about it |
In addition, if you notice any yellowing of the skin or whites of the eyes (signs of jaundice) or sudden wheeziness or tightness of the chest contact your doctor or go to the accident and emergency department of your local hospital at once.
How to store melphalan
- Keep all medicines out of the reach of children.
- Melphalan tablets should be stored in a refrigerator at 2°C to 8°C and kept dry.
Important information about all medicines
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| © EMIS 2007 | DocID: 1001 |
DocRef: dils2354 |
Last Updated: 24 Aug 2007 |
Date of Next Review: 23 Aug 2009 |
Version: 22 |
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