Rifampicin

About rifampicin

Rifampicin is an antibiotic used to treat infections, including tuberculosis (also known as TB). It can also be used to prevent infections in those who have been in contact with serious infections.

Before taking rifampicin

Before taking rifampicin make sure your doctor or pharmacist knows:

• If you are pregnant, trying for a baby or breast-feeding.
• If you have liver problems, including jaundice (yellowing of the skin and whites of the eyes).
• If you have kidney problems.
• If you have porphyria (a blood disorder).
• If you are taking other medicines, including those available to buy without a prescription, herbal or complementary medicines.
• If you have ever had an allergic reaction to this or any other medicine.

How to take rifampicin

• Before beginning treatment, read the manufacturer's printed information leaflet.
• Take your medication exactly as directed by your doctor.
• You must complete the course of rifampicin.
• Do not stop taking rifampicin without speaking to your doctor first
• Rifampicin must be taken on an empty stomach (half to one hour before food).
• Try to take rifampicin at the same time each day to avoid missing any doses.
• If you forget to take a dose, take one as soon as you remember unless it is nearly time for your next dose. Do not take two doses at the same time to make up. If in doubt, speak to your pharmacist or doctor.
• Rifampicin is sometimes given three times a week as part of a supervised treatment known as intermittent directly observed therapy (DOT).

Getting the most from your treatment

• Important: rifampicin reduces the effects of oral contraception. You should use an alternative method of contraception such as an intra-uterine device (IUD) or condom while taking this medication and for up to eight weeks after completing the course. Speak to your doctor for advice.
• This medicine may colour urine, saliva and other body fluids orange-red. This is completely harmless and should be no cause for concern.
• Rifampicin can cause discolouration of soft contact lenses and you should not wear these during treatment.
• You must keep your regular appointments with your doctor. You will need to have regular blood and urine tests while taking rifampicin.
• Do not stop taking this medicine without speaking to your doctor first.
• If you are diabetic, you may need to monitor your blood glucose levels more frequently. Your doctor will be able to advise you about this.
• If you buy any medicines, check with a pharmacist that they are safe to take with your other medicines.

Can rifampicin cause problems?

Along with their useful effects all medicines can cause unwanted side effects, which usually improve as your body adjusts to the new medicine. Speak with your doctor or pharmacist if any of the following side effects continue or become troublesome.

How to store rifampicin

• Keep all medicines out of the reach of children.
• Store in a cool, dry place, away from direct heat and light.

Important information about all medicines