Methotrexate

About methotrexate

Methotrexate is used to treat conditions where some kind of over-activity in the body is causing problems. Methotrexate prevents this over-activity.

1. Cancers form when cells in the body multiply in a way that is out of control and abnormal. These cells then spread and destroy nearby tissues. Methotrexate works by stopping the cancer cells from dividing and multiplying.
2. It is thought that rheumatoid arthritis is caused by excessive activity of the immune system; methotrexate may work by suppressing this excessive activity and so reducing inflammation.
3. In psoriasis, methotrexate prevents the excessive division and multiplication of skin cells that causes skin scaling and raised plaques.

Before taking methotrexate

Before taking methotrexate make sure your doctor or pharmacist knows:

• If you are pregnant, trying for a baby or breast-feeding.
• If you suffer from liver or kidney problems.
• If you suffer from any blood disorders.
• If you are suffering from diarrhoea.
• If you have any stomach problems.
• If you are pregnant or breastfeeding.
• If you and your partner are trying for a baby.

Before you start taking methotrexate your doctor will arrange a chest x-ray and do some blood tests.

How to take methotrexate

• Usually doses of methotrexate are given WEEKLY. Make sure that you take each dose on the correct day and at the correct time. Methotrexate is only occasionally taken more frequently, usually when the patient is in hospital. Do not take this medicine every day, unless you are sure your doctor has instructed you to do so.
• Methotrexate tablets are available in two strengths: 2.5 mg and 10 mg. The amount of methotrexate you take will have been carefully calculated for your particular condition and to suit your individual requirements. Make sure you take the correct dosage. If you are not sure how many to take or your tablets look different to your last prescription speak to your doctor or pharmacist for advice.
• Handle the tablets as little as possible.

Getting the most from your treatment

• While you are taking methotrexate, and for a while after you stop treatment, do not have any immunisations (vaccinations) without talking to your doctor first. Methotrexate lowers the body's resistance and there is a chance that you may get an infection from live vaccines.
• Do not take medicines containing aspirin, ibuprofen or folic acid while taking methotrexate, without first consulting your doctor. Some over the counter medicines for colds may contain aspirin or ibuprofen. Check with your pharmacist if you are unsure about the contents of any medicine.
• Avoid drinking alcohol while you are taking methotrexate.
• You should be given a treatment booklet when you start to take methotrexate. Use this to record your dose of methotrexate and any test results. Take this booklet to all your doctor and hospital appointments and to the Pharmacy when you collect your prescription. If you have not been given a treatment booklet ask for one at your next appointment.

Can methotrexate cause problems

Along with their useful effects all medicines can cause unwanted side effects, which usually improve as your body adjusts to the new medicine. Speak with your doctor or pharmacist if any of the following side effects continue or become troublesome.

How to store methotrexate

• Keep all medicines out of the reach of children.
• Store in a cool, dry place, away from direct heat and light.

Important information about all medicines