Indapamide

About indapamide

This belongs to the group of medicines known as diuretics.

Diuretics are often referred to as water tablets.

Indapamide is used to treat hypertension (high blood pressure). It removes excess water from the body by increasing how often you urinate (pass water).

Indapamide is available in tablet form. It is also available as a modified release preparation, which means indapamide is released slowly over the day to give an even effect.

It is also sometimes known as: Natrilix; Natrilix SR. You may notice the use of any of these names on the packaging of your medicine.

Before taking indapamide

Before taking any indapamide make sure your doctor or pharmacist knows:

• if you are pregnant, trying for a baby or breast-feeding
• if you suffer from liver or kidney problems
• if you have recently suffered from a stroke
• if you suffer from gout or have a history of gout
• if you suffer from Addison's disease or diabetes
• if you suffer from porphyria (blood disorder) or systemic lupus erythematosus (SLE)
• if you suffer from hypokalaemia (low blood potassium)
• if you suffer from prostate problems or have problems urinating (passing water)
• if you suffer from overactivity of the parathyroid gland
• if you have ever had an allergic reaction to this or any other medicine
• if you are taking any other medicines, including those available to buy without a prescription, herbal or complementary medicines

How to take indapamide

• Always read the manufacturer's information leaflet, if possible, before beginning treatment.
• Take indapamide exactly as directed by your doctor or pharmacist.
• Indapamide will make you urinate (pass water) more often, so your doctor or pharmacist will usually advise you to take your dose in the morning so as not to disturb your sleep. If you take more than one dose per day, take the last dose before 6pm in the evening.
• If you miss a dose of indapamide take it as soon as you remember. However, if it is after 6pm in the evening skip the missed dose and continue taking it at the usual times. Never take two doses at the same time.
• Swallow indapamide modified release tablets whole (not crushed or chewed) with a glass of water.
• Indapamide is for you. Never give it to others, even if their condition appears to be the same as yours.
• Never take more than the prescribed dose. If you suspect that you or someone else has taken an overdose of indapamide contact your doctor or go to the accident and emergency department of your local hospital at once. Always take the container with you, if possible, even if it is empty.

Getting the most from your treatment

• Before taking any 'over-the-counter' medicines, check with your pharmacist which medicines are safe for you to take alongside indapamide.
• Keep your regular appointments with your doctor so that your progress can be monitored. Your doctor may suggest that you have annual blood tests to check your levels of sodium and potassium.
• Avoid excessive consumption of alcohol. Too much alcohol can cause a big drop in blood pressure and may lead to fainting.
• Many patients with high blood pressure do not feel unwell, but left untreated high blood pressure can harm the heart and arteries and damage blood vessels resulting in a heart attack, stroke, heart failure or kidney failure.
• It is very important to take indapamide exactly as your doctor has directed and not to stop taking it without speaking to your doctor first, even if you feel quite well.
• It is important to follow any dietary advice that you have been given by your doctor. If you are overweight, your doctor may want you to follow a weight reducing diet.
• Diuretics help you to lose water. On occasions you may lose too much and become dehydrated, leaving you feeling thirsty and your skin looking and feeling dry.
• Indapamide may cause a dry mouth. If you experience this try chewing sugar-free gum, sucking sugar-free sweets or pieces of ice. If a dry mouth becomes too troublesome, discuss the problem with your doctor or pharmacist.
• Indapamide may cause you to experience faintness or dizziness when getting up from a lying or sitting position. Getting up slowly should help. If this becomes too troublesome ask your doctor or pharmacist for advice.
• Before having any kind of surgery, including dental and emergency treatment, tell the surgeon, dentist or doctor that you are taking indapamide.
• If you have diabetes indapamide may affect your blood sugar levels. Test your urine or blood regularly and report any extreme changes to your doctor.
• Indapamide may cause your skin to become more sensitive to sunlight than it is usually. Avoid bright sunlight and sunbeds and use a sun cream higher than factor 15 until you know how your skin reacts.

Can indapamide cause problems?

Along with their useful effects all medicines can cause unwanted side effects. These usually improve as your body adjusts to the new medicine. Speak to your doctor or pharmacist if any of the following side effects continue or become troublesome.

Headache, dizziness, tiredness, muscle cramps, feeling sick, loss of appetite, diarrhoea, constipation, indigestion, skin rashes, being aware of your heartbeat, pins and needles, light-headedness, dry mouth, or sexual problems.

Indapamide can occasionally cause you to lose too much potassium or sodium from the body. The correct balance of sodium and potassium in the body is essential for good health.

Severe sickness and diarrhoea may increase your chances of potassium or sodium loss. If you experience this contact your doctor or pharmacist as soon as possible.

Signs of excessive potassium loss are dryness of the mouth, increased thirst, irregular heartbeat, mood changes, muscle cramps or pain, feeling or being sick, unusual tiredness or weakness, a weak pulse or loss of appetite.

Signs of excessive sodium loss are confusion, convulsions (fits), difficulty concentrating, irritability, muscle cramps and unusual tiredness or weakness.

If you think you may be suffering from a lack of potassium or sodium, or if you experience any other worrying symptoms, which you think may be due to this medicine, discuss them with your doctor or pharmacist.

How to store indapamide

• Keep out of reach of children.
• Store in a cool, dry place, away from direct light and heat.
• Never keep out of date or unwanted medicines. Discard them safely out of the reach of children or take them to your local pharmacist who will dispose of unwanted medicines for you.

© EMIS and Cegedim Pharmacy Services Ltd 2005   Updated: 23/11/2005