Before taking paroxetine

Before taking paroxetine make sure your doctor or pharmacist knows:

• If you are under 18 years of age.
• If you are pregnant, trying for a baby or breast-feeding.
• If you have heart, kidney or liver problems.
• If you have epilepsy.
• If you have diabetes.
• If you have glaucoma (increased pressure in your eye).
• If you have a bleeding disorder.
• If you have ever had abnormally 'high' moods.
• If you are being treated with electroconvulsive therapy (ECT).
• If you have ever had an allergic reaction to this or to any other medicine.
• If you have taken an antidepressant known as a monoamine-oxidase inhibitor (MAOI) within the previous two weeks.
• If you are taking any other medicines, including those available to buy without a prescription, herbal and complementary medicines.

How to take paroxetine

• Before starting this treatment, read the manufacturer's printed information leaflet from inside the pack.
• Take paroxetine exactly as your doctor has told you. It is usually taken once each day in the morning.
• Take paroxetine with a snack or after eating a meal.
• If you are taking paroxetine tablets, swallow them whole with a drink of water. Do not crush or chew the tablets.
• If you are taking paroxetine oral liquid, do not take indigestion remedies for the two hours before and the two hours after you take the medicine.
• Try to take your doses at the same time each day as this will help you to avoid missing any.
• If you do forget to take a dose, take it as soon as you remember. If you do not remember until the following day, skip the missed dose. Do not take two doses together to make up for a forgotten dose.

Getting the most from your treatment

• You may feel that paroxetine is not working for you straightaway. It can take a week or two after starting this treatment before the effect begins to build up, and 4-6 weeks before you feel the full benefit. Do not stop taking it after a week or so, thinking it is not helping.
• Try to keep your regular appointments with your doctor. This is so your doctor can check on your progress.
• You are advised not to drink alcohol while you are being treated with paroxetine. Taking paroxetine and alcohol may increase the chance that you experience side-effects.
• If you have diabetes you may need to check your blood glucose more frequently, as paroxetine may affect the levels of sugar in your blood. Your doctor will be able to advise you about this.
• Paroxetine may cause your skin to become more sensitive to sunlight than usual. Avoid strong sunlight and sunbeds until you know how your skin reacts.
• If you buy any medicines, check with a pharmacist that they are safe to take with paroxetine.
• There are several types of antidepressants and they differ in their possible side-effects. If you find that paroxetine does not suit you then let your doctor know, as another may be found that will.
• Do not stop taking paroxetine unless your doctor tells you to do so. Stopping treatment suddenly can cause problems and your doctor will probably want you to reduce your dose gradually if this is necessary.
• While you feel depressed or are taking paroxetine, you may have thoughts about harming yourself or ending your life. It is very important that you tell your doctor about this if it happens.
• If you are taking paroxetine for depression, you should expect that a normal course of treatment will last for around six months after your symptoms have eased.

Can paroxetine cause problems?

Along with their useful effects, most medicines can cause unwanted side-effects although not everyone experiences them. These usually improve as your body adjusts to the new medicine, but speak with your doctor or pharmacist if any of the following side-effects continue or become troublesome.

• Any swelling of the mouth or face.
• Any shortness of breath or difficulty swallowing.
• An itchy rash.

If you experience any other symptoms which you think may be due to this medicine, speak with your doctor or pharmacist.

How to store paroxetine

• Keep all medicines out of the reach and sight of children.
• Store in a cool, dry place, away from direct heat and light.

Important information about all medicines

References

• Manufacturer's PIL, Seroxat® Tablets, GlaxoSmithKline UK, electronic Medicines Compendium. Dated April 2010.
• Manufacturer's PIL, Seroxat® 20 mg/10 ml oral suspension, GlaxoSmithKline UK, electronic Medicines Compendium. Dated April 2010.
• British National Formulary; 62nd Edition (Sep 2011) British Medical Association and Royal Pharmaceutical Society of Great Britain, London (link to current BNF)