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Paroxetine
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About paroxetine
| Type of medicine | Selective serotonin re-uptake inhibitor (SSRI) |
| Used for | Depression Anxiety disorders |
| Also called | Seroxat® |
| Available as | Tablets Oral liquid |
Certain chemicals in our brain control how we feel. It is thought that low levels of a chemical called serotonin can lead to depression and other conditions. Paroxetine works by helping to regulate serotonin levels in our body, easing the symptoms of depression, anxiety and feelings of panic.
Before taking paroxetine
Before taking paroxetine make sure your doctor or pharmacist knows:
- If you are pregnant, trying for a baby or breast-feeding.
- If you suffer from heart, liver or kidney problems.
- If you are under 18 years of age.
- If you suffer from epilepsy, diabetes mellitus (sugar diabetes), glaucoma (increased eye pressure) or a bleeding disorder.
- If you have suffered from mania (great excitement, hallucinations, difficulty in concentrating or staying still).
- If you are being treated with ECT (electroconvulsive therapy).
- If you have ever had an allergic reaction to this or any other medicine.
- If you have taken a monoamine oxidase inhibitor (MAOI) antidepressant within the last two weeks.
- If you are taking any other medicines, including those available to buy without a prescription, herbal or complementary medicines.
How to take paroxetine
- Before beginning treatment, read the manufacturer's printed information leaflet.
- Take paroxetine exactly as directed by your doctor.
- Take paroxetine tablets each morning with or after a meal. Swallow them whole, with a drink of water.
- Take paroxetine liquid each morning with or after a meal. If you take indigestion remedies, do not take them within two hours of taking this medicine.
- Try to avoid missing any doses. If you do miss a days dose, don't worry just take the next days dose when it is due. Do not take two doses together.
- You may have to take paroxetine for several weeks before you feel the full effect.
- Do not stop taking paroxetine without speaking to your doctor first. Your doctor will want to reduce your dose gradually as stopping suddenly can cause problems.
Getting the most from your treatment
- Before taking any 'over-the-counter' medicines check with your pharmacist which medicines are safe for you to take alongside paroxetine.
- Keep your regular appointments with your doctor.
- Paroxetine may slow your reactions. Make sure your reactions are normal before driving or doing any other tasks that would be dangerous if you were not fully alert.
- It is sensible to avoid drinking alcohol whilst receiving paroxetine.
- Paroxetine may cause your skin to become more sensitive to sunlight than it usually is. Avoid sunbeds and try to avoid sunlight or use a suncream higher than factor 15 until you know how your skin reacts.
Can paroxetine cause problems
Along with their useful effects all medicines can cause unwanted side effects, which usually improve as your body adjusts to the new medicine. Speak with your doctor or pharmacist if any of the following side effects continue or become troublesome.
| Common side-effects - these affect less than 1 in 10 people who take this medicine | What can I do if I experience this |
| Feeling or being sick, diarrhoea | Eat little and often. Stick to simple foods such as dry toast and drink plenty of water to replace lost fluids |
| Sleepiness, dizziness, weakness | Make sure your reactions are normal before driving, operating machinery or doing any other jobs which could be dangerous if you were not fully alert |
| Dry mouth | Try chewing sugar-free gum, pieces of ice or sugar-free sweets |
| Headache | Ask your pharmacist to recommend a suitable pain-killer. If the headache continues, speak with your doctor |
| Constipation | Try to eat a well-balanced diet containing plenty of fibre and drink 6-8 glasses of water each day |
| Increased sweating, yawning, shakiness, difficulty focusing, difficulty sleeping, agitation, nervousness, loss of appetite, weight changes, difficulty concentrating, anxiety, sexual difficulties and unusual face movements | Speak with your doctor if any of these become troublesome |
Important: If you have any thoughts of harming yourself or suicide whilst you are taking paroxetine, tell your doctor straight away.
If you experience any other symptoms that you think may be due to this medicine, speak with your doctor or pharmacist.
How to store paroxetine
- Keep all medicines out of the reach of children.
- Store in a cool, dry place, away from direct heat and light.
Important information about all medicines
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References
- British National Formulary; 54th Edition (September 2007) British Medical Association and Royal Pharmaceutical Society of Great Britain, London
- Manufacturer's PIL, Paroxetine 20mg and 30 mg Tablets, Actavis, electronic Medicines Compendium. Text revised May 2007, accessed 31 January 2008.
- Manufacturer's PIL, Seroxat® Tablets, GlaxoSmithKline UK, electronic Medicines Compendium. Written 2007, accessed 31 January 2008.
- Manufacturer's PIL, Seroxat® Liquid, GlaxoSmithKline UK, electronic Medicines Compendium. Written 2007, accessed 31 January 2008.
The authors and editors of this article are employed to create accurate and up to date content reflecting reliable research evidence, guidance and best clinical practice. They are free from any commercial conflicts of interest. Find out more about updating.
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