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  • Keep your regular doctor's appointments. Your doctor may need to test your blood to decide the correct dose for you.
  • Do not stop taking phenytoin without speaking to your doctor first.
  • If you develop a skin rash, fever, mouth ulcers, or unexplained bruising or bleeding, tell your doctor straight away.

About phenytoin

Type of medicine Antiepileptic
Used for Epilepsy
Also called Phenytoin sodium
Epanutin®
Available as Tablets, capsules, infatabs (chewable tablets), oral suspension

Phenytoin works by reducing the activity in the brain. It is used to control convulsions (fits or seizures) in some forms of epilepsy.

Phenytoin is also occasionally used to treat certain types of nerve pain such as trigeminal neuralgia (severe burning or stabbing pain often following the course of a nerve in the face) when other treatments are unsuitable.

Before taking phenytoin

Before taking phenytoin make sure your doctor or pharmacist knows:

  • If you are pregnant, trying for a baby or breast-feeding.
  • If you suffer from liver problems.
  • If you suffer from porphyria (a blood disorder).
  • If you have ever had an allergic reaction to this or any other medicine.
  • If you are taking any other medicines, including those available to buy without a prescription, herbal and complementary medicines.

How to take phenytoin

  • Take phenytoin exactly as you have been told by your doctor.
  • Before beginning treatment, read the manufacturer's printed information leaflet.
  • It is best to take phenytoin with or after food.
  • Swallow the capsules whole with a drink of water.
  • Phenytoin chewable tablets may be chewed before swallowing or they can be swallowed whole with a drink of water.
  • If you are taking phenytoin oral suspension, make sure you shake the bottle before you measure out your dose.
  • Try to take phenytoin at the same times each day to avoid missing any doses.
  • If you do forget to take a dose, take one as soon as you remember unless it is nearly time for your next dose. If so, then skip the missed dose. Do not take two doses at the same time to make up.

Getting the most from your treatment

  • Keep your regular doctor's appointments so that your progress can be monitored.
  • People with epilepsy must stop driving. Your doctor will advise you about when it may be possible for you to resume driving again. This will usually be after a year free of seizures.
  • Do not stop taking phenytoin without speaking to your doctor first. Stopping suddenly may cause fits. Your doctor will need to reduce the dose you are taking gradually.
  • The amount of phenytoin contained in the liquid or chewable tablet forms of phenytoin may be different from that in the capsule or tablet forms. For this reason it is important that you do not change the form of phenytoin that you are taking without discussing it first with your doctor.
  • It is best not to drink alcohol with phenytoin. This is because alcohol can alter the amount of phenytoin in your body.
  • If you are having any treatment like an operation or dental treatment, tell the person carrying out the treatment that you are taking phenytoin.
  • If you buy any medicines (including herbal remedies), check with a pharmacist that they are safe to take with phenytoin.

Can phenytoin cause problems

Along with their useful effects all medicines can cause unwanted side effects, which usually improve as your body adjusts to the new medicine. Speak with your doctor or pharmacist if any of the following side effects continue or become troublesome.

Common side-effects - these affect less than 1 in 10 people who take this medicine What can I do if I experience this
Feeling or being sick Eat little and often. Stick to simple foods
Constipation Eat a well balanced diet containing plenty of fibre. Drink 6-8 glasses of water each day
Dizziness, drowsiness Getting up slowly should help. Make sure your reactions are normal before driving, operating machinery or doing any other jobs which could be dangerous if you were not fully alert
Headache Ask your pharmacist to recommend a suitable pain-killer
Rash Let your doctor know about this, even if it is mild
Difficulty sleeping, nervousness, unsteadiness, shakiness, numbness or tingling sensations, weight loss, sore or swollen gums, acne, increased hair growth, difficulty controlling movements If any of these are particularly troublesome, let your doctor know

Important: If you develop a fever, persistent sore throat, skin rash, mouth ulcers, or unexplained bruising or bleeding, contact your doctor straight away.

Important: While you are taking phenytoin, there is a small risk that you may develop mood changes, distressing thoughts and feelings about suicide. If this happens, tell your doctor straight away.

If you experience any other symptoms which you think may be due to this medicine, speak with your doctor or pharmacist.

How to store phenytoin

  • Keep all medicines out of the reach and sight of children.
  • Store in a cool, dry place, away from direct heat and light.

Important information about all medicines


  • Keep all medicines out of the sight and reach of children.
  • Make sure that the person prescribing this medicine knows about any other medicines that you are taking. This includes medicines you buy and herbal and homeopathic medicines.
  • If you buy any medicines check with a pharmacist that they are safe to take with your other medicines.
  • Before taking this medicine tell your doctor if you have ever had an allergic reaction after taking any medicine.
  • Never take more than the prescribed dose. If you suspect that you or someone else has taken an overdose of this medicine go to the accident and emergency department of your local hospital at once. Take the container with you, even if it is empty.
  • If you are having any treatment like an operation or dental treatment tell the person carrying out the treatment which medicines you are taking.
  • Always read the printed information leaflet that comes with your medicine.
  • This medicine is for you. Never give it to other people even if their condition appears to be the same as yours.
  • Never keep out of date or unwanted medicines. Take them to your local pharmacy which will dispose of them for you.
  • If you have any questions about this medicine ask your pharmacist.

References

Comprehensive patient resources are available at www.patient.co.uk
© EMIS 2009 DocID: 1460 DocRef: dils2024 Last Reviewed: 19 Jan 2009 Version: 22

The authors and editors of this article are employed to create accurate and up to date content reflecting reliable research evidence, guidance and best clinical practice. They are free from any commercial conflicts of interest. Find out more about updating.

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