Epilepsy With Partial Seizures

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There are different types of epilepsy. This leaflet is about epilepsy with partial seizures. Other leaflets in this series include: 'Epilepsy - A General Introduction', 'Epilepsy with Tonic-Clonic Seizures', 'Epilepsy with Absence Seizures', 'Could it be Epilepsy', 'Living with Epilepsy' and 'Treatments for Epilepsy'.

What is a seizure?

A seizure is a short episode of symptoms which is caused by a burst of abnormal electrical activity in the brain. Typically, a seizure lasts from a few seconds to a few minutes. (Older words for seizures include convulsions and fits.)

The brain contains millions of nerve cells (neurones). Normally, the nerve cells are constantly sending tiny electrical messages down nerves to all parts of the body. Different parts of the brain control different parts and functions of the body. Therefore, the symptoms that occur during a seizure depend on where the abnormal burst of electrical activity occurs.

There are different types of seizures but they are broadly divided into two main types - generalised and partial. Many people associate epilepsy with generalised 'convulsive' seizures. However, some people develop partial seizures.

What is a partial seizure?

With a partial seizure the burst of electrical activity stays in one part of the brain. Therefore, you tend to have localised or 'focal' symptoms. Different parts of the brain control different functions and so symptoms depend on which part of the brain is affected.

Simple partial seizures
In this type of seizure you may have muscular jerks or strange sensations in one arm or leg. You may feel, hear, see, smell, or taste odd sensations. Some people develop pins and needles in one part of the body. However, you do not lose consciousness or awareness. A simple partial seizure usually lasts just a few seconds or minutes. For each individual, the same movement or sensation tends to recur each time a seizure occurs.

Complex partial seizures
During this type of partial seizure, you are not aware of your surroundings, or what you are doing. In effect, you have a partial loss of consciousness (which differs from a simple partial seizure). This type of seizure can arise from any part of the brain but most commonly arises from a temporal lobe (a part of the brain). Therefore, this type is sometimes called 'temporal lobe seizures'.

The temporal lobes of the brain help to deal with mood and 'behaviour'. Therefore, you may have strange feelings, sensations, and emotions during a complex partial seizure. It may feel like being in a dream. Your surroundings may appear strange or oddly familiar. It may be difficult to explain the feelings or sensations that occur. To an onlooker, you may appear to be in a trance or behave strangely for a few seconds or minutes. For example, you may wander with no apparent purpose. Some people smack their lips, fumble at clothes, appear to fidget, swallow repeatedly, or do other repetitive movements.

Sometimes a partial seizure develops into a generalised 'convulsive' seizure. This is called a secondary generalised seizure.

What is epilepsy?

If you have epilepsy, it means that you have had repeated seizures. If you have a single seizure, it does not necessarily mean that you have epilepsy. About 1 in 20 people have a seizure at some time in their life. It may be the only one that occurs. The definition of epilepsy is 'more than one seizure'. The frequency of seizures in people with epilepsy varies. In some cases there may be years between seizures. At the other extreme, in some cases the seizures occur every day. For others, the frequency of seizures is somewhere in between these extremes.

Epileptic seizures arise from within the brain. A seizure can also be caused by external factors which may affect the brain. For example, a high fever may cause a 'febrile convulsion'. Other causes of seizures include: lack of oxygen, a low blood sugar level, certain drugs, poisons, and a lot of alcohol. Seizures caused by these external factors are not classed as epilepsy.

What causes epilepsy?

Unknown cause ('idiopathic epilepsy')
In many cases, no cause for the seizures can be found. The abnormal bursts of electrical activity in the brain occur 'out of the blue'. It is unclear why they start, or continue to occur. Genetic (hereditary) factors may play a part in some cases. People with idiopathic epilepsy usually have no other neurological (brain) condition. Medication to control seizures usually works well.

Symptomatic epilepsy
In some cases, an underlying brain condition or brain damage causes epilepsy. Some conditions are present at birth. Some conditions develop later in life. There are many such conditions. For example: a patch of scar tissue in a part of the brain, a head injury, stroke, cerebral palsy, some genetic syndromes, tumours of the brain, previous infections of the brain such as meningitis, encephalitis, etc. The condition may 'irritate' the surrounding brain cells and trigger seizures.

Some underlying conditions may cause no other problems apart from seizures. In other cases, the underlying condition may cause other problems or disabilities in addition to the seizures.

These days, with more advanced scans and tests, a cause can be found for some cases previously thought to be idiopathic (unknown cause). For example, a small piece of scar tissue in the brain, or a small anomaly of some blood vessels inside the brain. These may now be found by modern brain scanning equipment which is more sophisticated than in the past.

What triggers a seizure?

There is often no apparent reason why a seizure occurs at one time and not another. However, some people with epilepsy find that certain 'triggers' make a seizure more likely. These are not the cause of epilepsy, but may trigger a seizure on some occasions. Possible triggers include:

• Stress or anxiety.
• Some medicines such as anti-depressants, anti-psychotic medication (by lowering the seizure threshold in the brain).
• Lack of sleep or tiredness.
• Irregular meals which nay cause a low blood sugar level.
• Heavy drinking, or street drugs.
• Flickering lights such as from strobe lighting or video games.
• Menstruation (periods).
• Illnesses which cause fever such as 'flu or other infections.

See a doctor if you have had a 'possible seizure' or similar event. Sometimes it is difficult for a doctor to confirm that you have had a seizure. The most important part of confirming the diagnosis is the description of what happened. Other conditions can look like seizures. For example, faints, panic attacks, collapses due to heart problems, breath-holding attacks in children, and other problems.

Therefore, it is important that a doctor has a clear description of what happened during the 'event'. Preferably this is from the person affected, and also from an eyewitness. The description may be typical of a seizure. However, sometimes it is difficult for a doctor to definitely confirm the diagnosis. Tests such as brain scans, EEG (brainwave recordings), and blood tests may help.

• A brain scan (usually an MRI or CT scan) can show the structure of different parts of the brain. A brain scan is not always necessary.
• EEG (ElectroEncephaloGram). This test records the electrical activity of the brain. Special stickers are placed on various parts of the scalp. They are connected to the EEG machine. This amplifies the tiny electrical messages given off by the brain, and records their pattern on paper or computer. The test is painless. Some types of seizure produce typical EEG patterns. However, a normal recording does not rule out epilepsy, and not all EEG abnormalities are related to epilepsy.
• Blood tests and other tests may be advised to check on your general well being. They may also look for other possible causes of the 'event'.

Although helpful, tests are not foolproof. It is possible to have epilepsy with normal test results. Also, if an abnormality is found on a brain scan, it does not prove that it causes seizures. However, tests may help to decide if the 'event' was a seizure, or caused by something else. It is unusual for a diagnosis of epilepsy to be made after one seizure, as the definition of epilepsy is 'recurrent seizures'. For this reason a doctor may suggest to 'wait and see' if it happens again before making a firm diagnosis of epilepsy.

How can I help someone having a partial seizure?

As partial seizures can take many different forms, bystanders need to take a common sense approach. Nearly all partial seizures stop within a few minutes by themselves. Gentle and quiet reassurance may be all that is needed until the seizure ends. If the affected person appears confused or is wandering, try to guide them away from any danger.

Sometimes a partial seizure develops into a convulsive seizure, so be aware of this. It may be best to try and guide the person to sit down in a soft chair or away from any dangerous places. Stay with the person until they are fully recovered and are fully aware of their surroundings.

What are the treatments for epilepsy?

Medication
Epilepsy cannot be 'cured' with medication. However, various medicines can prevent seizures. They work by stabilising the electrical activity of the brain. You need to take medication every day to prevent seizures. Seizures are well controlled by medication in about 4 out of 5 cases. Deciding on which medicine to prescribe depends on such things as: the type of epilepsy, age, other medicines that you may take for other conditions, possible side-effects, pregnancy, etc.

One medicine can prevent seizures in most cases. A low dose is usually started at first. The dose may be increased if this fails to prevent seizures. In some cases two medicines are needed to prevent seizures.

The decision when to start medication may be difficult. A first seizure may not mean that you have epilepsy as a second seizure may never happen, or occur years later. The decision to start medication should be made by weighing up all the pros and cons of starting, or not starting, the medicine. A common option is to 'wait and see' after a first seizure. If you have a second seizure within a few months, more are likely. Medication is commonly started after a second seizure that occurs within 12 months of the first. However, there are no definite rules and the decision to start medication should be made after a full discussion with your doctor.

Some points about medication for epilepsy include the following.

• Ask your doctor how long treatment is likely to be advised. This will vary from case to case. If you have not had seizures for several years, you may wish to try stopping medication. But this depends on your particular type of epilepsy. There are many different types of epilepsy, some of which are age dependent, but some that will need medication for life. Your life circumstances may influence the decision about stopping medication. For example, if you have recently regained your driving licence, the risk of losing it again for a year if a seizure occurs may affect your decision. However, if you are a teenager who has been free of seizures for some years, you may be happy to take the risk.
• Although the list of possible side-effects for each medicine seems long, in practice, most people have few or no side-effects, or just minor ones. Ask your doctor which side-effects are important to look out for. If you develop a troublesome side-effect it may be dose-related, or may diminish in time. Alternatively, a switch to another medicine may be advised.
• Medicines which are used for other conditions may interfere with medication for epilepsy. If you are prescribed or buy another medicine, remind your doctor or pharmacist that you take medication for epilepsy. Even things like indigestion medicines may interact with your epilepsy medication which may increase your chance of having a seizure.
• Some medicines for epilepsy interfere with the contraceptive pill. A higher dose pill may be needed for effective contraception.
• Tell your doctor if you intend to become pregnant. Pre-conception counselling is important for women with epilepsy.
• If you have epilepsy, you are exempt from prescription charges for all your prescriptions. You need an exemption certificate. You can get this from your pharmacist or by contacting the Prescription Helpline: 0845 601 8076.

• Surgery to remove a cause of seizures in the brain is an option in a small number of cases. It may be considered when medication fails to prevent seizures. It is only possible for certain causes in certain areas of the brain. So, only a small number of people are suitable for surgery. Also, there is risk involved in brain surgery. However, techniques continue to improve and surgery may become an option for more and more people in the future.
• Vagal Nerve Stimulation is an option for some people
• The Ketogenic diet, a diet that needs to be supervised by an experienced dietician, is useful for some children and adults with particular types of epilepsy.
• Complementary therapies such as aromatherapy may help with relaxation and relieve stress, but have no proven effect on preventing seizures.

What is the outlook (prognosis) for people with epilepsy?

The success in preventing seizures by medication varies depending on the type of epilepsy. For example, if no underlying cause can be found for your seizures (idiopathic epilepsy), you have a good chance that medication can fully control your seizures. Seizures caused by some underlying brain problems may be more difficult to control.

The overall outlook is better than many people realise. The following figures are based on studies of people with epilepsy which looked back over a five year period. These figures are based on grouping people with all types of epilepsy together which gives an overall picture.

• About 5 in 10 people with epilepsy will have no seizures at all over a five year period. Many of these people will be taking medication to stop seizures. Some will have stopped treatment having had two or more years without a seizure whilst taking medication.
• About 3 in 10 people with epilepsy will have some seizures in this five year period, but far fewer than if they had not taken medication.
• So, in total, with medication, about 8 in 10 people with epilepsy are 'well controlled' with either no, or few, seizures.
• The remaining 2 in 10 people experience seizures, despite medication.

A trial without medication may be an option if you have not had any seizures over 2-3 years. If a decision to stop treatment is made, a gradual reduction of the dose of medication is usually advised over several months. Never stop taking medication without discussing with a doctor.

The above section on outlooks (prognosis) relates just to seizures. Some underlying brain conditions which cause seizures may cause additional problems.

Most people with epilepsy live full and active lives, but may have to accept some changes to their lifestyle. For example, you must not drive for a period laid down by law. Below are further sources of information, help, and support on all aspects of epilepsy.

Epilepsy Action
New Anstey House, Gateway Drive, Leeds, LS19 7XY
Helpline: 0808 800 50 50    Web: www.epilepsy.org.uk

National Society For Epilepsy
Chesham Lane, Chalfont St Peter, Gerrards Cross, Bucks, SL9 0RJ
Helpline: 01494 601 400    Web: www.epilepsynse.org.uk

Epilepsy Scotland
48 Govan Road, Glasgow, Scotland, G51 1JL
Helpline: 0808 800 2 200    Web: www.epilepsyscotland.org.uk

Epilepsy Wales
PO Box 4168, Cardiff, CF14 0WZ
Helpline: 0845 7413774    Web: www.epilepsy-wales.co.uk

© EMIS and PIP 2005   Updated: September 2005   PRODIGY Validated

The authors and editors of this article are employed to create accurate and up to date content reflecting reliable research evidence, guidance and best clinical practice. They are free from any commercial conflicts of interest. Find out more about updating.

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