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Rhabdomyolysis and Myoglobinuria, What is rhabdomyolysis? Rhabdomyolysis can be defined as a clinical syndrome associated with the breakdown of skeletal muscle fibres a...
This led to the term 'white collar rhabdomyolysis'. [ 5 ] In another series, exercise-induced rhabdomyolysis accounted for 47% of the admissions with rhabdomyolysis. [ 6 ...
Later signs include complex arrhythmias, cyanosis, hypoxia, hypotension, electrolyte abnormalities, rhabdomyolysis and severe hyperthermia. Hyperthermia is a late sign. Rhabdomyolysis...
The main symptoms are often tiredness, cramping and exercise intolerance. [ 5 ] Presentation Clinical presentation and severity are very variable but patients typically experience reversibl...
There is traumatic rhabdomyolysis. Muscle injury causes large quantities of potassium, phosphate, myoglobin, creatine kinase and urate to leak into the circulation.
Polymyositis . Rhabdomyolysis . Other forms of poisoning (for example, strychnine). Other drug toxicity (anticholinergics, selective serotonin reuptake inhibitors).
Encephalitis . Rhabdomyolysis . Meningitis . Withdrawal syndromes. Wernicke's encephalopathy. Investigations There are no specific confirmatory investigations - ...
Acute pancreatitis. Acute rhabdomyolysis - usually in relation to crush injuries. Malignancy - tumour lysis (following chemotherapy) or osteoblastic metastases (most common in prostate ...
Creatine phosphokinase (CPK) may be helpful in identifying muscle breakdown from ischemia, damage, or rhabdomyolysis . If rhabdomyolysis is being considered, renal function tests...
Other possible manifestations These include acute kidney injury, abnormal LFTs, and rhabdomyolysis. Rare manifestations These include osteomyelitis, pericarditis, peritonitis, endocardi...
Muscle weakness (diaphragmatic, cardiac and skeletal), bone pain, rhabdomyolysis, and altered mental status (confusion, hallucinations) are the most common presenting features.
Other possible features Seizures and CNS depression. Rhabdomyolysis . The features of ricin poisoning can be so nonspecific that a high index of suspicion is required to ...
If there is significant crush injury , compartment syndrome , or severe burns, rhabdomyolysis may cause hyperkalaemia and myoglobinuric renal failure . Burns from military white pho...
Later manifestations include rhabdomyolysis, cardiac failure, hypotension, arrhythmias, respiratory failure, seizures and coma.
Cardiomyopathy. Rhabdomyolysis . Acute kidney injury . Encephalopathy and cerebral oedema. Acute respiratory distress syndrome .
Exceptions to this rule are problems caused by radiocontrast nephropathy, severe burns, acute glomerulonephritis and rhabdomyolysis. In patients who are receiving diuretics, a fracti...
Creatinine levels can be increased by muscle damage (rhabdomyolysis) and decreased tubular secretion - eg, cimetidine, trimethoprim. Ingestion of cooked meat and severe exercise cause a ra...
The powerful toxins lead to breakdown of cells, coagulation and microvascular thrombosis and these can consequently add or contribute to rhabdomyolysis and acute kidney injury. The toxins als...
Endogenous - eg, tumour lysis syndrome, rhabdomyolysis, trauma, burns: Massive tissue damage leads to loss of potassium into the circulation.
Urinalysis - query rhabdomyolysis; save sample for possible toxicological analysis. CXR if there is suspected pulmonary oedema/aspiration.