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These cytotoxic antibiotics are often grouped together, even though they have diverse mechanisms of action, very different indications, a range of efficacies and distinctive toxicities. [ 1 ] Mem...
Complications are uncommon but may include endophthalmitis , traumatic lens injury, retinal detachment , uveitis and periocular infections. [ 8 ] Systemic side-effects - hypersensitivity re...
Cells derived from Fanconi's anaemia patients are severely sensitive to DNA cross-linking agents, including mitomycin C, psoralen-UVA, cisplatin and diepoxybutane. [ 3 ] The condition...
TUR alone is only possible as a therapeutic option if tumour growth is limited to the superficial muscle layer and if re-staging biopsies are negative for residual tumour. [ 11 ] People with susp...
Management : topical steroids, subconjunctival mitomycin C and silicone contact lenses are used initially. Most patients will also benefit from systemic steroids, dapsone ± cytotoxic age...
Retinoids Topical or intralesional retinoids have been used in clinical trials and produced moderate improvements but should not be considered first-line. [ 19 ] Other treatments being ...
Diagnosis of Fanconi's anaemia depends upon the detection of chromosomal aberrations (breaks, rearrangements, radials, exchanges) in cells after culture with a DNA interstrand cross-linking agent ...
For people with advanced chronic open-angle glaucoma, offer glaucoma surgery with pharmacological augmentation (mitomycin C - an antimetabolite used during the initial stages of trabeculectom...
Second-generation chemotherapeutic agents include ifosfamide, vinblastine, vindesine, mitomycin C and platinums (carboplatin and cisplatin). More recently, the third-generation drugs (gemcita...