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Malignant Hyperthermia, Synonyms: malignant hyperpyrexia, malignant hyperthermia susceptibility, MHS, hyperthermia of anaesthesia, King syndrome, King-Denborough syndrome...
Tachycardia. Hyperthermia. Hyperactive bowel sounds. Mydriasis. Excessive sweating. 2. Neuromuscular dysfunction - namely: Tremor.
Signs There will be hyperthermia with temperature above 38°C. Muscular rigidity (lead-pipe type) will always be present.
Patients may need to have a temperature-controlled environment, wear light clothing and maintain hydration with cool fluids to avoid hyperthermia if they suffer from hypohidrosis. It is cl...
Hypothermia or hyperthermia. Thrombotic thrombocytopenic purpura . Poisoning (carbon monoxide, lead). Inherited neurometabolic disorders ( homocystinuria , hereditary coproporphyri...
Differential diagnosis There are a number of enzyme defects that can cause myoglobinuria [ 6 ] as well as other causes to remember: Biochemical abnormalities (eg hypokalaemia , hypophosphat...
Heatstroke This is a combination of hyperthermia (classically defined as a core body temperature of at least 40.6°C), [ 4 ] often with loss of the capacity to dissipate heat, and ...
Anaesthetic complications - a dangerous, malignant hyperthermia-like reaction with some anaesthetic agents. Cardiomyopathy may be the first presentation, if muscle weakness is subclinical....
Prognosis Untreated hyperthyroid crisis is usually fatal due to hyperthermia, cardiac arrhythmias, multi-organ failure [ 11 ] , and sepsis [ 6 ] . Even with early diagnosis and...
Lactic acidosis may occur as a consequence of vigorous or prolonged exercise but is usually of no consequence and self-correcting, unless other pathology such as hyperthermia is present. ...
Anaesthetic complications - eg, myoglobinuria, rhabdomyolysis or malignant hyperthermia after certain anaesthetics. Fatigue - this is common [ 5 ] . Assessment and diagnosis - genera...
Sweating and hyperthermia. Dry mouth. Decreased gastrointestinal (GI) motility. Dilated pupils. Tremor.
Malignant hyperthermia - very rare. Investigations These may include: FBC. Arterial blood gases.
It may also present with transient hemiplegia, hypothermia or hyperthermia, convulsions, diplopia and strabismus. If untreated, it can progress to stupor, coma and, exceptionally, death.
Anaesthesia risk - Individuals with NS should be considered at risk of malignant hyperthermia when receiving general anaesthesia, and certain anaesthetic agents need to be avoided.
Assessment and investigations [ 7 ] When assessing a person with suspected acute amphetamine toxicity: Ask about which amphetamines were taken, the method of ingestion, quantity, time of ex...
If the patient presents with physical symptoms, perform a systematic examination and exclude common acute medical complications - pulmonary oedema, heart failure, myocardial infarction, stroke, hy...
Disorders of thermoregulation: temperature can suddenly rise up to as high as 41.7°C (107°F) in a life-threatening condition such as heatstroke , thyroid storm , neuroleptic malignant syn...
Fractures may occur as a result of the blood pressure cuff or a tourniquet, or may occur when moving the patient. Hyperthermia and increased sweating may also be a problem. Prenatal opt...
There may also be: Tachycardia. Hyperthermia and excessive sweating. Hypertension. Tachypnoea. Tremor. Mydriasis. Ataxia.