- Classic, or acute, mastoiditis is a rare complication of acute otitis media (AOM).
- Chronic, latent, or masked, mastoiditis presents in a chronic, or subclinical, fashion. It is usually associated with chronic suppurative otitis media or cholesteatoma.
- Mastoiditis in acute or chronic form is now quite rare.
- Before the advent of antibiotics, mastoiditis was relatively common. It developed in 5-10% of children with acute otitis media (AOM), with a mortality rate of 2 per 100,000 children. The mortality rate is now <0.01 per 100,000 children.
- Current rates are in the order of 0.12 diagnoses per 1,000 child-years.
- The rates of mastoiditis seem to be higher in countries where antibiotic prescribing rates for AOM are lower but this, in itself, does not prove a causal relationship. If a causal link is assumed, it is estimated that the numbers needed to treat with antibiotics are 50,000 children to avoid one child developing mastoiditis.
- As serious complications are rare, guidance is that the routine use of antibiotics in AOM is not thought to be justified by the potential reduction in risk of these complications. See separate article Acute Otitis Media.
- A BMJ review looked at trends in antibiotic prescribing rates in UK general practice between 1993 and 2003 and admissions for peritonsillar abscess, mastoiditis and rheumatic fever in children between 1993 and 2002. Antibiotic prescribing rates halved during this time but hospital admission rates for mastoiditis had increased by 19% over the preceding 10 years. The authors suggested that the apparent increase could reflect coding error and that the reduction in general practice events could reflect the fact that sick children are increasingly being taken straight to hospital.
- Much more common in young children, with peak incidence at age 6-13 months.
- Patients with immunocompromise may be more prone to mastoiditis.
- Children or adults with intellectual impairment or communication difficulties are thought to be susceptible to the condition, possibly as a result of not being able to communicate their symptoms.
- Pre-existence of cholesteatoma is a risk factor for subsequent mastoiditis.
- Streptococcus pneumoniae (most frequently isolated).
- S. pyogenes.
- Staphylococcus spp.
- Haemophilus influenzae.
- Pseudomonas aeruginosa (becoming increasingly common).
- Moraxella catarrhalis.
- Other Gram-negative organisms (occur more frequently in chronic form).
- Mycobacteria (rare).
- Aspergillus and other fungi (rare).
Acute (classic) mastoiditis
- History of acute or recurrent episodes of otitis media.
- Otalgia and pain behind the ear.
- Infants may present with irritability, intractable crying and feeding problems.
- Swelling, redness or a boggy, tender mass behind the ear.
- The external ear may protrude forwards; fluctuance can sometimes be demonstrated behind the ear (examine from behind).
- Ear discharge may be present and the eardrum may be perforated.
- Tympanic membrane bulges and is erythematous.
- The patient is unwell.
- Presents in a subtle or subclinical fashion after an episode of acute otitis media (AOM) or with history of chronic suppurative otitis media.
- Recurrent bouts of otalgia and retro-aural pain.
- Recurrent headache.
- Episodes of fever.
- Infants may present with irritability, intractable crying and feeding problems.
- Tympanic membrane may appear infected or may be normal.
- May be no external evidence of peri-mastoid inflammation.
Other points on examination
- Examine for evidence of local neurological involvement. There may be an ipsilateral VIth or VIIth cranial nerve palsy, or pain over the distribution of the ophthalmic division of the Vth cranial nerve.
- The patient may complain of deafness and there may be signs of conductive deafness (Rinne's test negative; Weber's test - sound localised/loudest in the affected ear).
- There may be no history of otitis media, no mastoid area tenderness and no external signs of infection.
- Otitis media or externa.
- Trauma to the ear/mastoid.
- Cervical lymph node enlargement.
- Parotid swelling.
- Bone cysts or tumours.
- Basal skull fracture.
- Other source of intracranial or localised sepsis.
- Pyrexia of unknown origin.
- FBC may show leukocytosis.
- ESR may be elevated.
- Blood cultures should be taken.
- Fluid can be extracted from the middle ear through perforated drums or by intervention (tympanocentesis) and should be sent for Gram staining, culture and acid-fast stain.
- Skull X-ray of the mastoid area is not usually helpful but may show clouding of mastoid air cells.
- CT and/or MRI scanning can be used for to aid diagnosis and look for intracranial complications. Some say that CT scanning should be used in all suspected cases of mastoiditis and others suggest a more conservative approach. In addition, MRI may be less useful than CT scanning.
- Lumbar puncture should be carried out if intracranial spread is suspected.
- Audiograms during and after mastoiditis help to quantify and monitor any associated hearing loss.
- Patients with suspected mastoiditis should be managed in a hospital setting.
- Appropriate clinical suspicion and prompt diagnosis are important to reduce the likelihood of complications.
- The usual initial therapy is high-dose, broad-spectrum intravenous (IV) antibiotics, given for at least 1-2 days (eg with a third-generation cephalosporin).
- Oral antibiotics are usually used after this, starting on IV treatment after 48 hours without fever, and continuing for at least 1-2 weeks.
- Paracetamol, ibuprofen and other agents may be given as antipyretics and/or painkillers.
- Myringotomy ± tympanostomy tube insertion may be performed in some cases as a therapeutic procedure, or to collect middle ear fluid for culture.
- Surgical intervention, usually in the form of mastoidectomy ± tympanoplasty, is suggested if there is:
- Mastoid osteitis.
- Intracranial extension.
- Abscess formation.
- Co-existing cholesteatoma.
- Limited improvement after IV antibiotics.
- Mastoidectomy can be:
- Simple: infected mastoid air cells are removed.
- Radical: the tympanic membrane and most middle ear structures are removed and the Eustachian tube is closed.
- Modified: the ossicles and part of the tympanic membrane is preserved.
- Incision and drainage of a subperiosteal abscess in another procedure that may be required.
- Patients with intracranial spread may also need neurosurgical intervention.
- In cases with unusual infecting organisms, specialist infectious disease input may be helpful.
- Conductive and/or sensorineural hearing loss.
- Osteomyelitis or bone erosion.
- Extension to the zygoma (zygomatic mastoiditis).
- Subperiosteal abscess (abscess between the periosteum and mastoid bone; gives appearance of a protruding ear).
- Cranial nerve palsies (especially V, VI and VII).
- Intracranial spread leading to extradural abscess, cerebral abscess, subdural empyema and meningitis.
- Intracranial venous sinus thrombosis (eg lateral sinus thrombosis).
- Bezold's abscess (spread of pus from mastoid process along the digastric muscle to other neck muscles).
- Petrositis causing Gradenigo's syndrome (VIth cranial nerve palsy + deep trigeminal facial pain + suppurative otitis media).
- Carotid artery spasm, arteritis, occlusion, rupture or metastatic septic emboli leading to intracerebral infection (all very rare and associated with the most severe cases).
Nowadays the prognosis for the vast majority of cases that are diagnosed early is excellent with a low chance of complications or severe hearing loss. A recent review reported that most who had suffered an episode of acute mastoiditis had no long-term otological sequelae. However, complicated cases may still lead to significant morbidity or even death.
The disease itself is difficult to prevent, except possibly by electing to treat some severe cases of acute otitis media (AOM) with adequate doses and duration of appropriate antibiotics. The sequelae of the condition can be prevented by having an appropriate index of suspicion for the condition and admitting patients suspected of having mastoiditis for early hospital assessment.
Failure to diagnose mastoiditis leading to life-threatening complications or death, is a recurrent, if relatively rare, cause of legal claims made against general practitioners in the UK. It should be borne in mind that the symptoms and signs can be quite subtle in chronic or latent mastoiditis.
Further reading & references
- Kavanagh K; Acute Coalescent Mastoiditis, Otology online, ENT USA.; good images including the protruding auricle
- Chase KS et al; Mastoiditis, Medscape, Sep 2009
- Bluestone CD; Clinical course, complications and sequelae of acute otitis media. Pediatr Infect Dis J. 2000 May;19(5 Suppl):S37-46.
- Brook I; Antimicrobial therapy of otitis media reduces the incidence of mastoiditis. Curr Infect Dis Rep. 2010 Jan;12(1):1-3.
- Otitis media - acute, Clinical Knowledge Summaries (July 2009)
- Damoiseaux RA; Antibiotic treatment for acute otitis media: time to think again. CMAJ. 2005 Mar 1;172(5):657-8.
- Sharland M, Kendall H, Yeates D, et al; Antibiotic prescribing in general practice and hospital admissions for peritonsillar abscess, mastoiditis, and rheumatic fever in children: time trend analysis. BMJ. 2005 Aug 6;331(7512):328-9. Epub 2005 Jun 20.
- Glasziou PP et al.,; Antibiotics for acute otitis media in children. Cochrane review abstract and plain language summary. Cochrane Database of Sytematic Reviews. 2006(2).
- Diagnosis and management of childhood otitis media in primary care, Scottish Intercollegiate Guidelines Network - SIGN (2003)
- Petersen I, Johnson AM, Islam A, et al; Protective effect of antibiotics against serious complications of common respiratory tract infections: retrospective cohort study with the UK General Practice Research Database. BMJ. 2007 Nov 10;335(7627):982. Epub 2007 Oct 18.
- Tamir S, Schwartz Y, Peleg U, et al; Acute mastoiditis in children: is computed tomography always necessary? Ann Otol Rhinol Laryngol. 2009 Aug;118(8):565-9.
- Polat S, Aksoy E, Serin GM, et al; Incidental diagnosis of mastoiditis on MRI. Eur Arch Otorhinolaryngol. 2011 Feb 5.
- Jose J, Coatesworth AP, Anthony R, et al; Life threatening complications after partially treated mastoiditis. BMJ. 2003 Jul 5;327(7405):41-2.
- Glynn F, Osman L, Colreavy M, et al; Acute mastoiditis in children: presentation and long term consequences. J Laryngol Otol. 2008 Mar;122(3):233-7. Epub 2007 Jul 19.
|Original Author: Dr Sean Kavanagh, Dr Michelle Wright||Current Version: Dr Gurvinder Rull|
|Last Checked: 23/05/2011||Document ID: 947 Version: 25||© EMIS|
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