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Galantamine
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About galantamine
| Type of medicine | Acetylcholinesterase inhibitor |
| Used for | Mild to moderate dementia associated with Alzheimer's disease |
| Also called | Reminyl® Reminyl® XL |
| Available as | Tablets, modified release capsules (galantamine is released slowly to give an even effect), and oral solution |
Galantamine cannot cure dementia or Alzheimer's disease but it can slow down the progression of dementia and can help to ease the symptoms of memory loss, confusion and changes in behaviour. It works by increasing the amount of a natural chemical in the brain called acetylcholine which is known to be lower in people suffering from Alzheimer's dementia.
Before taking galantamine
Before taking galantamine make sure your doctor or pharmacist knows:
- If you are pregnant, trying for a baby or breast-feeding.
- If you suffer from liver, kidney or heart problems.
- If you suffer from stomach ulcers, asthma or other problems that affect breathing.
- If you have difficulty urinating or have severe constipation.
- If you have had any recent surgery to the stomach, intestines or bladder.
- If you know you have a high or low blood potassium level.
- If you are taking other medicines, including those available to buy without a prescription, herbal or complementary medicines.
- If you have ever had an allergic reaction to this or any other medicine.
How to take galantamine
- Before beginning treatment, read the manufacturer's printed information leaflet.
- Take your medication exactly as directed by your doctor.
- Galantamine should be taken with or immediately after a meal.
- If you are taking the modified release form of galantamine, it should be swallowed whole and not chewed.
- Try to take galantamine at the same times each day to avoid missing any doses.
- Doses of the oral solution are measured using a pipette which is supplied with the bottle. Each 1 ml contains 4 mg of galantamine. If you are unsure how to measure out your dose, ask your pharmacist to show you. The solution can be swallowed directly, or it can be mixed with any non-alcoholic drink.
- If you forget to take a dose, take one as soon as you remember unless it is nearly time for your next dose. Do not take two doses at the same time to make up. If in doubt, speak to your pharmacist or doctor.
Getting the most from your treatment
- If you are having any treatment like an operation or dental treatment, tell the person carrying out the treatment which medicines you are taking.
- Keep your regular doctor's appointment so your progress can be monitored.
- Make sure that you drink plenty of water while you are taking galantamine.
- It may take several weeks before galantamine appears to take effect. You should not stop taking your medication unless your doctor tells you to.
- If you buy any medicines, check with a pharmacist that they are safe to take with your other medicines.
Can galantamine cause problems?
Along with their useful effects all medicines can cause unwanted side effects, which usually improve as your body adjusts to the new medicine. Speak with your doctor or pharmacist if any of the following side effects continue or become troublesome.
| Common side-effects | What can I do if I experience this |
| Feeling or being sick, indigestion, stomach pain | Eat little and often. Stick to simple foods |
| Diarrhoea | Drink plenty of water to replace any lost fuids |
| Dizziness, drowsiness, feeling tired | Make sure your reactions are normal before operating machinery, driving or doing anything else that could be dangerous if you were not fully alert |
| Headache | Ask your pharmacist to recommend a suitable pain-killer. If the headache continues, tell your doctor |
| Loss of appetite, weight loss, runny nose, confusion, problems sleeping, mood changes, fainting, feeling unwell, shakiness, bladder infections or difficulty urinating (passing water), changes in blood pressure and fever. | If troublesome, speak with your doctor |
If you experience any other symptoms which you think may be due to this medicine, speak with your doctor or pharmacist.
How to store galantamine
- Keep all medicines out of the reach of children.
- Store in a cool, dry place, away from direct heat and light.
- The oral solution should not be used for longer than 3 months after first being opened.
Important information about all medicines
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References
- Manufacturer's PIL, Reminyl® Tablets, Shire Pharmaceuticals Ltd., electronic Medicines Compendium. Dated April 2006, accessed 28 May 2008.
- Manufacturer's PIL, Reminyl® Oral Solution, Shire Pharmaceuticals Ltd., electronic Medicines Compendium. Dated April 2006, accessed 28 May 2008.
- Manufacturer's PIL, Reminyl® XL, Shire Pharmaceuticals Ltd., electronic Medicines Compendium. Dated March 2006, accessed 28 May 2008.
- British National Formulary; 55th Edition (March 2008) British Medical Association and Royal Pharmaceutical Society of Great Britain, London (link to current BNF).
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