About trandolapril

Trandolapril is in a class of drugs called angiotensin-converting enzyme (ACE) inhibitors.

Angiotensin-converting enzyme (ACE) is an enzyme in the body that is necessary in the formation of a chemical called angiotensin II. Angiotensin II causes the narrowing of arteries, thereby increasing blood pressure. ACE inhibitors prevent the formation of angiotensin II, hence widening the blood vessels and helping lower the blood pressure.

Trandolapril can be used on its own or alongside other medicines, such as verapamil, to help lower the blood pressure.

Before taking trandolapril

Before taking trandolapril make sure your doctor or pharmacist knows:

• If you are pregnant, trying for a baby or breast-feeding.
• If you are under 18 years of age.
• If you suffer from kidney or liver problems.
• If you are on a salt restricted diet or use salt substitutes which contain potassium.
• If you have dialysis treatment.
• If you are dehydrated (for example if you have had diarrhoea and sickness very recently).
• If you have atherosclerosis (the build-up of fatty deposits on the walls of arteries).
• If you suffer from peripheral vascular disease (a particular type of poor circulation).
• If you suffer from a collagen vascular disease, such as systemic lupus erythematosus (SLE) or scleroderma.
• If you have cardiomyopathy (cardiac muscle disease) or aortic stenosis (narrowing of the blood vessel from the heart).
• If you have a history of angioedema (where the face, tongue and throat swell).
• If you are taking other medicines, including those available to buy without a prescription, herbal or complementary medicines.
• If you have ever had an allergic or unusual reaction to any other ACE inhibitor (this includes ramipril, lisinopril and perindopril) or to any other medicine.

How to take trandolapril

• Before beginning treatment, read the manufacturer's printed information leaflet.
• Take your medication exactly as directed by your doctor.
• It is not important whether you take your dose before or after food.
• If you are taking the modified-release capsules (Tarka®), these release trandolapril and verapamil slowly to give a more even effect. Swallow these capsules whole, do not crush or chew them.
• Trandolapril is usually taken once a day. Try to take trandolapril at the same time each day to avoid missing any doses.
• If you forget to take a dose, take it as soon as you remember unless it is nearly time for your next dose, in which case leave out the missed dose. Do not take two doses together to make up for a missed dose.

Getting the most from your treatment

• Keep your regular doctor's appointment so your progress can be monitored.
• If you buy any medicines, check with a pharmacist that they are safe to take with trandolapril.
• Do not take indigestion remedies at the same time as trandolapril. If you need to take an indigestion remedy, leave at least two hours before or after your dose of trandolapril.
• Treatment with trandolapril is usually life-long.
• Trandolapril may cause dizziness or lightheadedness, especially the first time you take it. Make sure you know how you react to this medicine before you drive, operate machinery or do other jobs that could be dangerous if you were not fully alert.

Can trandolapril cause problems?

Along with their useful effects, all medicines can cause unwanted side-effects although not everyone experiences them. These usually improve as your body adjusts to the new medicine, but speak with your doctor or pharmacist if any of the following side-effects continue or become troublesome.

Important: if you experience any of the following, speak with your doctor or go to your local accident and emergency department without delay:

• Difficulty breathing, swelling of the face, mouth, tongue or throat.
• Jaundice (yellowing of the skin and whites of the eyes).

If you experience any other symptoms which you think may be due to this medicine, speak with your doctor or pharmacist.

How to store trandolapril

• Keep all medicines out of the reach and sight of children.
• Store in a cool, dry place, away from direct heat and light.

Important information about all medicines