About proguanil

Proguanil is used to prevent malaria. It is usually used in combination with another antimalarial medicine to increase its effectiveness. 

Malaria is a serious infection. It is common in tropical countries such as parts of Africa, Asia and South America. Malaria is a disease which is passed on to humans by infected mosquitoes. A parasite called plasmodium lives inside the stomachs of infected female mosquitoes and is passed on to humans by a bite.

Because the pattern of malaria varies with the part of the world you are travelling to, as well as the season and the type of activity you have planned, you should always obtain the latest advice about malaria prevention from your doctor, pharmacist or travel organiser. A backpacking trip may well require different preventative measures against malaria to those needed for a business trip to a city.

Proguanil is not prescribable on the NHS, but you are able to buy the tablets without a prescription at a pharmacy.

Before taking proguanil

Some medicines are not suitable for people with certain conditions, and sometimes a medicine may only be used if extra care is taken. For these reasons, before you start taking proguanil it is important that your doctor or pharmacist knows: 

• If you are pregnant, trying for a baby or breast-feeding.
• If you have kidney problems.
• If you are taking any other medicines. This includes any medicines you are taking which are available to buy without a prescription, such as herbal and complementary medicines.
• If you have ever had an allergic reaction to a medicine.

How to take proguanil

• Before you take proguanil, read the manufacturer's printed information leaflet from inside the pack. The leaflet will give you more information about the tablets and a full list of side-effects which you may experience from taking them.
• Proguanil should ideally be taken for a week before entering an area where malaria occurs. This is to ensure there is sufficient medicine in your bloodstream to give you the required protection. If you are unable to take it for a full week before you leave, as a minimum, you must start taking the tablets at least 1-2 days before you travel. You should continue to take proguanil throughout your stay and for a further four weeks after you have left the area.
• Take the tablets exactly as your doctor or pharmacist has told you. You will be given tablets containing 100 mg of proguanil. Adults should take 200 mg daily, so this means taking two tablets every day. Take the two tablets at the same time. If the proguanil is for a child, read the directions on the label carefully as their dose will depend upon their age and weight.
• Take the tablets with a snack or just after a meal, and try to take your doses at about the same time of day, each day. The tablets can be crushed and mixed into milk, jam or honey to make them easier for children to swallow.
• If you forget to take a dose, take it as soon as you remember. If you do not remember until the following day, skip the missed dose. Do not take two doses together to make up for a forgotten dose. You should complete the course of tablets, unless you are told otherwise by a doctor. Make sure you continue to take the tablets for four weeks after your visit.

Getting the most from your treatment

• These tablets will help prevent you from getting malaria, but it is also important that you take the following precautions against being bitten by mosquitoes:
  • Cover up bare areas of your arms and legs with long-sleeved, loose-fitting clothing, long trousers and socks. This is especially important if you are outside after sunset, as this is when mosquitoes feed.
  • Use an effective insect repellant spray on your clothing and any area of your skin which is bare.
  • Spray the room with an insecticide each evening a couple of hours before you go to bed. Check your sleeping areas for mosquitoes - pay particular attention to furniture and areas under your bed where insects can hide.
  • If you are sleeping in an unscreened room, use a mosquito net impregnated with an insecticide.
• If you have been advised to have an oral vaccine to protect you against typhoid, you should arrange to have this so your course is finished at least three days before you start taking proguanil. This is because proguanil tablets can stop the vaccine from working properly.
• If you take a medicine for indigestion (such as an antacid), do not take it within 2-3 hours before or after taking proguanil tablets. This is because some magnesium-containing antacids interfere with the way proguanil is absorbed by your body, making it less effective.
• If you feel ill or develop a fever or flu-like symptoms while you are travelling or within one year of returning home, you should see your doctor straightaway. This is important, even if you have taken your antimalarial tablets correctly.

Can proguanil cause problems?

Along with their useful effects, most medicines can cause unwanted side-effects although not everyone experiences them. These usually improve as your body adjusts to the new medicine, but speak with your doctor or pharmacist if any of the following side-effects continue or become troublesome.

If you experience any other symptoms which you think may be due to this medicine, speak with your doctor or pharmacist.

How to store proguanil

• Keep all medicines out of the reach and sight of children.
• Store in a cool, dry place, away from direct heat and light.

Important information about all medicines