Penciclovir cream

  • Use penciclovir cream every two hours for four days.
  • To avoid spreading the infection, wash your hands before and after applying the cream. Remember infection can also spread to others.
  • This cream is for you. Do not share it with others even if their symptoms are the same as yours.
Type of medicine Antiviral cream
Used for Treatment of cold sores
Also called Fenistil®; Vectavir®
Available as Cream

Penciclovir is an antiviral agent. It works by attacking the herpes simplex virus that causes cold sores. It does not kill the virus, but it does prevent it from multiplying. This means that although it may have little effect on existing blisters, it can prevent them from getting worse. Also, if you use penciclovir cream as soon as your symptoms start then the cold sores may not last as long as usual and may be less severe.

To make sure this is the right treatment for you, before you start using penciclovir cream it is important that your doctor or pharmacist knows:

  • If you are pregnant. This is because, if you are expecting a baby, medicines should only be given on the advice of a doctor.
  • If your immune system is not working properly (for instance, if you have AIDS).
  • If you are taking or using any other medicines. This includes any medicines you are taking which are available to buy without a prescription, such as herbal and complementary medicines.
  • If you have ever had an allergic reaction to a medicine.
  • Before you start this treatment, read the manufacturer's printed information leaflet from inside your pack. The leaflet will give you more information about the specific brand of cream you have been given, and a full list of side-effects which you may experience from using it.
  • Apply the cream every two hours while you are awake. Dab the cream on the area rather than rubbing it in. This will minimise any damage to the blisters, which could cause pain and spread the virus around.
  • Start using the cream at the first sign of infection (for instance, when you first feel your skin tingling) and continue to use it for four days. Remember to wash and dry your hands before and after using penciclovir to prevent spreading any infection.
  • If you forget to use the cream, apply it as soon as you remember and then continue using it at your usual times.
  • Try to keep the areas affected by blisters as clean and dry as possible, and only touch the cold sores when you apply the cream.
  • Penciclovir cream is not intended for use in your mouth or near your eyes. If you have sores in either of these areas, you should make another appointment to see your doctor, as an alternative preparation may be more suitable for you.

Along with their useful effects, most medicines can cause unwanted side-effects although not everyone experiences them. These usually improve as your body adjusts to the new medicine, but speak with your doctor or pharmacist if any of the following side-effects continue or become troublesome.

Common penciclovir side-effects - these affect less than 1 in 10 people who use this medicine What can I do if I experience this?
Mild stinging, burning, or numbness These effects do not usually last for long, but if any become troublesome speak with your doctor or pharmacist

If you experience any other symptoms which you think may be due to penciclovir, speak with your doctor or pharmacist.

  • Keep all medicines out of the reach and sight of children.
  • Store in a cool, dry place, away from direct heat and light.

  • If you are having an operation or dental treatment, tell the person carrying out the treatment which medicines you are taking or using.
  • This preparation is for external use only. If someone swallows some of this preparation, go to the accident and emergency department of your local hospital. Take the container with you, even if it is empty.
  • This medicine is for you. Never give it to other people even if their condition appears to be the same as yours.
  • Never keep out-of-date or unwanted medicines. Take them to your local pharmacy which will dispose of them for you.
  • If you have any questions about this medicine ask your pharmacist.

Further reading & references

  • British National Formulary; 63rd Edition (Mar 2012) British Medical Association and Royal Pharmaceutical Society of Great Britain, London
Original Author: Helen Allen Current Version: Peer Reviewer: Dr Helen Huins
Last Checked: 26/09/2012 Document ID: 3684  Version: 23 © EMIS

Disclaimer: This article is for information only and should not be used for the diagnosis or treatment of medical conditions. EMIS has used all reasonable care in compiling the information but make no warranty as to its accuracy. Consult a doctor or other health care professional for diagnosis and treatment of medical conditions. For details see our conditions.