Norethisterone contraceptive injection

  • Norethisterone injection is used to prevent pregnancy. It provides contraception for 8 weeks.
  • Carefully read the information leaflet from the pack before receiving this treatment.
  • Possible side-effects include: changes in your periods, breast discomfort, headache, bloating and dizziness.
Type of medicine Progestogen
Used for Contraception
Also called Noristerat®
Available as Injection

Norethisterone is a progestogen, which is a female sex hormone. It is injected into a muscle in your bottom and will provide contraception for 8 weeks.

Norethisterone works by stopping your egg cells from ripening and being released and it also changes the lining of your womb to make it less likely that a fertilised egg will attach to it. The mucus that surrounds your cervix (neck of the womb) also becomes thicker so that the sperm cannot get through as easily to fertilise an egg.

Before having norethisterone injection make sure your doctor or pharmacist knows:

  • If you think you may be pregnant.
  • If you have ever had breast cancer or a cancer of the sex organs.
  • If you have vaginal bleeding other than your normal monthly period.
  • If you have been told you have any thickening of your arteries or if you have a problem in the way you metabolise fat.
  • If you have liver disease or problems with your liver.
  • If during a past pregnancy you have had jaundice.
  • If you have had an ectopic or abnormal pregnancy.
  • If you have sickle-cell anaemia, diabetes or high blood pressure.
  • If you are due to have an operation.
  • If you have porphyria (a rare blood disorder).
  • If you are taking other medicines, including those available to buy without a prescription, herbal and complementary medicines.
  • If you have ever had an allergic reaction to this or any other medicine.
  • It is important that before receiving this injection, you read the manufacturer's printed information leaflet. Discuss any questions you have with your doctor.
  • You will be given this injection by your nurse or doctor. It is given slowly into a muscle of your bottom.
  • The timing of the injection is important so remember to keep your clinic appointment.
  • This injection does not protect against HIV (AIDS) and other sexually transmitted diseases.
  • Your periods may change while you are using this injection. Spotting, breakthrough bleeding and delayed menstruation may occur. If you are concerned about any changes in your cycle, speak with your doctor.
  • Norethisterone injection provides contraception for 8 weeks and is often given as an interim measure (for example while your partner is having a vasectomy). Make sure your doctor knows if there is any delay in your longer-term plans for contraception.

Along with their useful effects, most medicines can cause unwanted side-effects although not everyone experiences them. These usually improve as your body adjusts to the new medicine, but speak with your doctor or pharmacist if any of the following side-effects continue or become troublesome.

Common side-effects What can I do if I experience this
Headache Ask your pharmacist to recommend a suitable painkiller. If the headache continues or is severe, let your doctor know
Dizziness Make sure your reactions are normal before driving, operating machinery or doing any other jobs which could be dangerous if you were not fully alert
Feeling sick This does not usually last for long, but in the meantime, stick to simple or bland foods and avoid rich, spicy foods
Bloating, breast discomfort, mood changes, skin reactions If any of these become troublesome, speak with your doctor

If you experience any other symptoms which you think may be due to this medicine, speak with your doctor or pharmacist.

  • Keep all medicines out of the reach and sight of children.
  • Store in a cool, dry place, away from direct heat and light.

  • If you are having an operation or any dental treatment, tell the person carrying out the treatment which medicines you are taking or using.
  • This medicine is for you. Never give it to other people even if their condition appears to be the same as yours.
  • Never keep out of date or unwanted medicines. Take them to your local pharmacy which will dispose of them for you.
  • If you have any questions about this medicine ask your pharmacist.

Further reading & references

  • British National Formulary; 60th Edition (September 2010) British Medical Association and Royal Pharmaceutical Society of Great Britain, London.
  • Manufacturer's PIL, Noristerat®; Manufacturer's PIL, Noristerat®, Bayer plc, electronic Medicines Compendium. Dated May 2008.
Original Author: Helen Allen Current Version:
Last Checked: 20/04/2011 Document ID: 13626  Version: 1 © EMIS

Disclaimer: This article is for information only and should not be used for the diagnosis or treatment of medical conditions. EMIS has used all reasonable care in compiling the information but make no warranty as to its accuracy. Consult a doctor or other health care professional for diagnosis and treatment of medical conditions. For details see our conditions.

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