Glimepiride (Amaryl)

Take glimepiride tablets shortly before, or during, your first meal of the day.

Remember to follow any advice you have been given about what you should or shouldn't eat, and try to take some regular exercise.

Side-effects are rare, but make sure you know how to recognise the symptoms of low blood sugar. These include feeling shaky or anxious, sweating, looking pale, feeling hungry, having palpitations, and feeling dizzy.

Type of medicine Sulfonylurea antidiabetic medicine
Used for Type 2 diabetes mellitus
Also called Amaryl®
Available as Tablets

Insulin is a hormone that is made naturally in your body, in the pancreas. It helps to control the levels of sugar in your blood. If your body does not make enough insulin to meet its needs, or if it does not use the insulin it makes effectively, this results in the condition called diabetes mellitus (sugar diabetes).

People with diabetes need treatment to control the amount of sugar in their blood. This is because good control of blood sugar levels reduces the risk of complications later on. Some people can control the sugar in their blood by making changes to the food they eat but for other people, medicines like glimepiride are given alongside the changes in diet.

Glimepiride works by increasing the amount of insulin that your pancreas releases. It can be given on its own or alongside other antidiabetic medicines or insulin.

Some medicines are not suitable for people with certain conditions, and sometimes a medicine may only be used if extra care is taken. For these reasons, before you start taking glimepiride it is important that your doctor or pharmacist knows:

  • If you are pregnant, trying for a baby or breast-feeding.
  • If you have kidney or liver problems.
  • If you have been told you have porphyria or glucose 6-phosphate dehydrogenase (G6PD) deficiency. These are rare inherited disorders.
  • If you are taking any other medicines. This includes any medicines you are taking which are available to buy without a prescription, such as herbal and complementary medicines.
  • If you have ever had an allergic reaction to a medicine.
  • Before you start this treatment, read the manufacturer's printed information leaflet from inside your pack. The leaflet will give you more information about glimepiride and a full list of side-effects which you may experience from taking it.
  • Take glimepiride exactly as your doctor has told you to. It is prescribed as a single dose to be taken shortly before, or during, breakfast. Swallow the tablets with a drink of water. To begin with, you will be asked to take 1 mg-strength tablets, although the strength of your tablets may be increased if needed. There are several strengths of glimepiride tablets.
  • If you forget to take a dose, take it as soon as you remember. If you do not remember until the following day, skip the missed dose. Do not take two doses together to make up for a forgotten dose.
  • It is important that you keep your regular doctor's and clinic appointments. This is so your progress can be monitored. You are likely to need regular check-ups with an eye clinic and a foot clinic as well as with your doctor and diabetes clinic.
  • Your doctor may recommend that you test for sugar in your blood or urine regularly to check that your diabetes is being controlled. Your doctor or diabetes nurse will show you how to do this.
  • If you have been given advice by your doctor about changes to your diet, stopping smoking or taking regular exercise, it is important for you to follow the advice you have been given.
  • Check with your doctor before taking up any new physical exercise, as this will have an effect on your blood sugar levels and you may need to check your blood or urine levels more regularly.
  • Drinking alcohol is not advisable with glimepiride. If you do have a drink, keep well within the recommended alcohol limits, as alcohol will affect the control of your blood sugar.
  • If you are due to have an operation or dental treatment, you should tell the person carrying out the treatment that you have diabetes and that you are taking glimepiride.
  • If you get unusually thirsty, pass urine more frequently, and feel very tired, then let your doctor know. Your dose of glimepiride may need adjusting.
  • Make sure you know what it feels like if your blood sugar is too low. This is known as hypoglycaemia, or a 'hypo'. The first signs of hypoglycaemia are feeling shaky or anxious, sweating, looking pale, feeling hungry, having palpitations (a feeling that your heart is pounding), and feeling dizzy. If these happen you should eat or drink something containing sugar or have a snack straightaway. Hypoglycaemia may occur if you miss a meal, if you exercise more than usual, if you are ill, or if you drink a lot of alcohol.
  • If you are a driver you should take special care, as your ability to concentrate may be affected if your diabetes is not well controlled. Make sure you know what it feels like if your blood sugar is low. You may be advised to check your blood or urine glucose levels before you travel and to have a snack with you on long journeys.
  • Treatment for diabetes is lifelong. Continue to take the tablets unless you are advised otherwise by your doctor.
  • If you buy any medicines, check with a pharmacist that they are suitable for you to take. This is because some medicines may interfere with glimepiride.

Along with their useful effects, most medicines can cause unwanted side-effects although not everyone experiences them. These usually improve as your body adjusts to the new medicine, but speak with your doctor or pharmacist if any of the following side-effects continue or become troublesome.

Glimepiride side-effects - these occur only rarely
What can I do if I experience this?
Feeling or being sick Stick to simple meals - avoid rich or spicy food. Make sure you take your tablets with food
Diarrhoea Drink plenty of water to replace any lost fluids
Constipation Eat a well-balanced diet and drink plenty of water
Signs of low blood sugar: feeling shaky or anxious, sweating, looking pale, feeling hungry, feeling that your heart is pounding, feeling dizzy Eat something containing sugar, such as a biscuit or a sugary drink (not diet), and follow this up with a snack such as a sandwich. Tell your doctor if you notice these symptoms, as your dose may need adjusting

If you experience any other symptoms which you think may be due to this medicine, speak with your doctor or pharmacist.

  • Keep all medicines out of the reach and sight of children.
  • Store in a cool, dry place, away from direct heat and light.

Never take more than the prescribed dose. If you suspect that you or someone else might have taken an overdose of this medicine, go to the accident and emergency department of your local hospital at once. Take the container with you, even if it is empty.

This medicine is for you. Never give it to other people even if their condition appears to be the same as yours.

Do not keep out-of-date or unwanted medicines. Take them to your local pharmacy which will dispose of them for you.

If you have any questions about this medicine ask your pharmacist.

Further reading & references

Disclaimer: This article is for information only and should not be used for the diagnosis or treatment of medical conditions. EMIS has used all reasonable care in compiling the information but make no warranty as to its accuracy. Consult a doctor or other health care professional for diagnosis and treatment of medical conditions. For details see our conditions.

Original Author:
Helen Allen
Current Version:
Peer Reviewer:
Dr John Cox
Document ID:
3232 (v26)
Last Checked:
12/06/2013
Next Review:
11/06/2016
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