About buserelin for women
|Type of medicine||Gonadorelin analogue|
|Used for||Before some types of fertility treatment|
|Available as||Injection and nasal spray|
Buserelin is a synthetic form of a hormone which occurs naturally in your body. It is used as part of some types of fertility treatment. It works by acting on the pituitary gland in your brain to stop the production of natural hormones that control the release of eggs from your ovaries. Other hormone treatments are then used to stimulate ovulation.
Buserelin is also used to treat endometriosis. Endometriosis is a condition where tissue that normally lines the inside of your uterus (womb) is found elsewhere in your body, often in the pelvic area or abdomen. Buserelin reduces the production of sex hormones by acting on your pituitary gland. Sex hormones can worsen certain problems associated with the menstrual cycle, such as endometriosis, so by reducing the levels of these sex hormones, buserelin will help relieve your symptoms.
Buserelin is also used in some disorders which affect men. There is a separate leaflet called Buserelin for men which gives more information about this.
Before using buserelin
Some medicines are not suitable for people with certain conditions, and sometimes a medicine may only be used if extra care is taken. For these reasons, before you start taking buserelin it is important that your doctor or pharmacist knows:
- If you are pregnant or breast-feeding.
- If you have polycystic ovary disease.
- If you have had any bleeding from your vagina that you do not think is related to your periods.
- If you have a tumour.
- If you have low moods or are depressed.
- If you have high blood pressure.
- If you have diabetes mellitus (sugar diabetes).
- If you have a bone disease such as osteoporosis.
- If you are taking or using any other medicines. This includes any medicines you are taking which are available to buy without a prescription, such as herbal and complementary medicines.
- If you have ever had an allergic reaction to a medicine.
How to take buserelin
- Before you start this treatment, read the manufacturer's printed information leaflet from inside your pack. The leaflet will give you more information about buserelin, and a full list of side-effects which you may experience.
- If you are having buserelin injections, these are usually administered to begin with by a doctor or a nurse. They are given just underneath the surface of your skin. As your treatment continues, you may be trained to give the injections yourself. In this case, your doctor will tell you how many times a day to use the injections and for how long. Follow these instructions carefully.
- If you are using buserelin nasal spray, your doctor will tell you what dose you should use and whether you should use the spray in one or both nostrils. This will depend upon the reason why you are using it, so follow the instructions you are given. If you are unsure about how or when to use the spray, ask your pharmacist to explain it to you again.
- Each time you open a new bottle of nasal spray, you will need to attach the nebuliser to the bottle of solution, and then ‘prime’ the spray. You do this by pumping the spray about 6 or 7 times until you see a fine mist. Priming the spray in this way, fills the nebuliser and tests that the spray is working correctly.
- It is important that you use this medicine regularly and space the doses out evenly through the day. If you forget a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and take your next dose when it is due. Do not take two doses together to make up for a forgotten dose.
Getting the most from your treatment
- Keep your appointments with your doctor so that your progress can be monitored.
- Even if you get a cold or your nose feels blocked, you should continue to use the spray, as it will still work. If you are using any other nasal sprays (such as decongestants), you should use buserelin spray first, then wait at least 30 minutes after using buserelin before using the other sprays.
- If you are being treated for endometriosis, you should use a non-hormonal method of contraception such as a condom. This is because hormonal methods (such as ‘the pill’ or ‘mini pill’) will not work. Speak with your doctor if you need further advice about what methods of contraception are suitable.
- Buserelin may affect your blood sugar levels. If you have diabetes you may need to check your blood glucose more frequently. Your doctor will be able to advise you about this.
Can buserelin cause problems?
Along with their useful effects, most medicines can cause unwanted side-effects although not everyone experiences them. These usually improve as your body adjusts to the new medicine, but speak with your doctor or pharmacist if any of the following side-effects continue or become troublesome.
|Common buserelin side-effects - these affect less than 1 in 10 people who take this medicine||What can I do if I experience this?|
|Menopausal symptoms such as hot flushes, dry vagina, increased sweating, reduced interest in sex||Speak with your doctor if this becomes severe or troublesome|
|Feeling dizzy, tired, or sleepy||If this happens, do not drive or use tools or machines|
|Feeling or being sick, stomach or abdominal pain||Stick to simple foods - avoid rich or spicy meals|
|Diarrhoea||Drink plenty of water to replace lost fluids|
|Constipation||Eat a well-balanced diet and drink several glasses of water each day|
|Vaginal bleeding and changes in your period||If this continues, speak with your doctor|
|Headache, muscle pain and stiffness||Ask your pharmacist to recommend a suitable painkiller|
|Irritation of your nose, nosebleeds, changes in the way things smell and taste, changes in your weight, feeling nervous or emotional, disturbed sleep, being aware of a fast heartbeat, dry skin, acne, changes in the thickness of your hair, and loss of concentration||If any of these become troublesome, speak with your doctor|
Important: if you get a skin rash or redness, or have any difficulties with breathing, you should contact your doctor for advice straightaway. These are rare but possibly serious symptoms, as they may be signs of an allergic reaction.
If you notice any other problems which you think may be caused by buserelin, speak with your pharmacist or doctor for advice.
How to store buserelin
- Keep all medicines out of the reach and sight of children.
- Store in a cool, dry place, away from direct heat and light.
- The nasal spray should only be used for five weeks once the bottle has been opened. Even if there is some solution left after this time, do not use it. Instead, open a fresh bottle.
Important information about all medicines
Further reading & references
- British National Formulary; 63rd Edition (Mar 2012) British Medical Association and Royal Pharmaceutical Society of Great Britain, London
- Manufacturer’s PIL, Suprecur® Injection; sanofi-aventis, The electronic Medicines Compendium. Dated November 2010.
- Manufacturer’s PIL, Suprecur® Nasal Spray Solution; sanofi-aventis, The electronic Medicines Compendium. Dated May 2011.
Disclaimer: This article is for information only and should not be used for the diagnosis or treatment of medical conditions. EMIS has used all reasonable care in compiling the information but make no warranty as to its accuracy. Consult a doctor or other health care professional for diagnosis and treatment of medical conditions. For details see our conditions.
Prof Cathy Jackson