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Tryptophan

  • Tryptophan will be started by a hospital specialist.
  • It may cause unwanted side-effects such as drowsiness, headache and feelings of sickness.

About tryptophan

Type of medicineAntidepressant
Used forDepression that has not got better despite the use of other antidepressant drugs
Also calledL-tryptophan
Optimax®
Available asTablets

It is thought that depression may be linked to an imbalance of chemicals in the brain. One chemical which is thought to influence mood is serotonin. To make serotonin, the body needs an amino acid called tryptophan. Taking tryptophan tablets helps to increase the production of serotonin in your brain, which improves symptoms such as low mood.

Tryptophan is used alongside other antidepressant treatment and will be started by a hospital specialist, although your doctor can then continue to prescribe it for you.

Before taking tryptophan

Before taking tryptophan make sure your doctor or pharmacist knows:

  • If you are pregnant, trying for a baby, or breast-feeding.
  • If you have a rare condition called eosinophilia-myalgia syndrome.
  • If you have ever had an allergic reaction to this or to any other medicine.
  • If you are taking any other medicines, including those available to buy without a prescription, herbal and complementary medicines.

How to take tryptophan

  • Before starting to take tryptophan, read the manufacturer's printed information leaflet.
  • Try to take tryptophan at the same times each day to avoid missing any doses.
  • Take tryptophan exactly as your doctor has told you to. The usual dose is two tablets taken three times each day, although your dose may be slightly higher or lower than this.
  • If you forget to take a dose, take one as soon as you remember unless it is nearly time for your next dose in which case skip the missed dose. Do not take two doses at the same time to make up for a missed dose.

Getting the most from your treatment

  • You must keep your regular appointments with your doctor who will want to check on your progress.
  • Suicidal thoughts may be associated with depression and the medicines used to treat it. You may be at risk of such thoughts early in your treatment, after a change in your dose, soon after stopping treatment, if you have previously thought about harming yourself, or if you are a young adult. Tell your doctor straight away if you are having any thoughts of harming yourself.
  • If you buy any medicines, check with a pharmacist that they are safe to take with tryptophan.
  • If you are having any treatment like an operation or dental treatment, tell the person carrying out the treatment which medicines you are taking.

Can tryptophan cause problems?

Along with their useful effects, all medicines can cause unwanted side-effects although not everyone experiences them. These usually improve as your body adjusts to the new medicine, but speak with your doctor or pharmacist if any of the following side-effects continue or become troublesome.

Side-effectsWhat can I do if I experience this
DrowsinessMake sure your reactions are normal before driving, operating machinery or doing any other jobs which could be dangerous if you were not fully alert
Feeling sickThis usually passes after a few days, but try eating simple foods and taking tryptophan after a meal
HeadacheAsk your pharmacist to recommend a suitable painkiller. If the headaches continue, speak with your doctor
Feeling light-headedAvoid tasks which require you to be alert, such as driving or operating machinery

Important: if you develop joint or muscle pain with a high temperature, breathlessness, extreme tiredness, swelling of your feet or ankles, and a skin rash, then speak with your doctor straight away as these may be signs of eosinophilia-myalgia syndrome.

If you experience any other symptoms which you think may be due to this medicine, discuss them with your doctor or pharmacist.

How to store tryptophan

  • Keep all medicines out of the reach and sight of children.
  • Store in a cool, dry place, away from direct heat and light.

Important information about all medicines


  • Never take more than the prescribed dose. If you suspect that you or someone else has taken an overdose of this medicine go to the accident and emergency department of your local hospital at once. Take the container with you, even if it is empty.
  • This medicine is for you. Never give it to other people even if their condition appears to be the same as yours.
  • Never keep out-of-date or unwanted medicines. Take them to your local pharmacy which will dispose of them for you.
  • If you have any questions about this medicine ask your pharmacist.

References

  • British National Formulary; 59th Edition (March 2010) British Medical Association and Royal Pharmaceutical Society of Great Britain, London.
Comprehensive patient resources are available at www.patient.co.uk
© EMIS 2010DocID: 1504DocRef: dils3679Last Reviewed: 21 Oct 2010Version: 23
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