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Trihexyphenidyl

  • Trihexyphenidyl is used to relieve Parkinson's symptoms.
  • The most common side-effects are a dry mouth, constipation, blurred vision, and difficulty passing urine.
  • Trihexyphenidyl may affect your ability to drive and use machines. Do not drive if you are not fully alert or able to see clearly.

About trihexyphenidyl

Type of medicineAntimuscarinic
Used forParkinson's disease and Parkinson's symptoms caused by other medicines
Also calledBroflex®
Available asTablets and oral liquid

The cause of Parkinson's disease is unknown but the condition results in a reduction in the amount of a chemical messenger in the brain known as dopamine. This lack of dopamine causes the symptoms of shaking, stiffness and slow movement. These symptoms are also sometimes experienced by people who do not have Parkinson's disease, as a side-effect of a medicine they are taking.

Trihexyphenidyl relieves the symptoms of Parkinson's by indirectly increasing the effects of dopamine.

Before taking trihexyphenidyl

Before taking trihexyphenidyl make sure your doctor or pharmacist knows:

  • If you are pregnant, trying for a baby or breast-feeding.
  • If you have liver or kidney problems.
  • If you have heart or blood vessel problems.
  • If you have prostate problems, or have been experiencing difficulty passing urine.
  • If you have been constipated for more than one week.
  • If you have glaucoma.
  • If you have high blood pressure.
  • If you have myasthenia gravis (a condition causing tired and weak muscles).
  • If you have ever had psychosis (a mental health problem).
  • If you are taking other medicines, including those available to buy without a prescription, herbal or complementary medicines.
  • If you have ever had an allergic reaction to this or to any other medicine.

How to take trihexyphenidyl

  • Before starting this treatment, read the manufacturer's printed information leaflet from inside the pack.
  • Take trihexyphenidyl exactly as your doctor has told you. You will probably be asked to slowly increase the number of doses you take until your symptoms improve.
  • If you have been given trihexyphenidyl tablets, take your dose with a snack or just after eating a meal.
  • Try to take trihexyphenidyl at the same times each day to avoid missing any doses.
  • If you forget to take a dose, take it as soon as you remember unless it is nearly time for your next dose, in which case leave out the missed dose. Do not take two doses together to make up for a forgotten dose.
  • If you have been taking trihexyphenidyl for some time, do not stop taking it without speaking with your doctor first. Stopping suddenly can cause problems so your doctor will want you to reduce your dose gradually.

Getting the most from your treatment

  • As your condition improves and your body movements become easier, be careful not to overdo physical activities. Physical activities must be increased gradually to allow your body to adjust to changes in balance, circulation and co-ordination. This is especially important if you are over 65 years of age.
  • Try to keep your regular appointments with your doctor. This is so your progress can be monitored.
  • If you are having an operation or dental treatment, tell the person carrying out the treatment that you are taking trihexyphenidyl.
  • If you buy any medicines, check with a pharmacist that they are safe to take with your other medicines.

Can trihexyphenidyl cause problems?

Along with their useful effects, most medicines can cause unwanted side-effects although not everyone experiences them. These usually improve as your body adjusts to the new medicine, but speak with your doctor or pharmacist if any of the following side-effects continue or become troublesome.

Common side-effects - these affect less than 1 in 10 people who take this medicineWhat can I do if I experience this
Dry mouthTry chewing sugar-free gum, or sucking sugar-free sweets. If this becomes troublesome, speak with your doctor
Feeling or being sickEat little and often. Stick to simple foods
Blurred vision, dizzinessIf this happens, do not drive or use tools or machines
ConstipationTry to eat a well balanced diet containing plenty of fibre, and drink 6-8 glasses of water each day
Difficulty passing urineIf this becomes troublesome, speak with your doctor

If you experience any other symptoms which you think may be due to this medicine, discuss them with your doctor or pharmacist.

How to store trihexyphenidyl

  • Keep all medicines out of the reach and sight of children.
  • Store in a cool, dry place, away from direct heat and light.

Important information about all medicines


  • Never take more than the prescribed dose. If you suspect that you or someone else has taken an overdose of this medicine go to the accident and emergency department of your local hospital at once. Take the container with you, even if it is empty.
  • This medicine is for you. Never give it to other people even if their condition appears to be the same as yours.
  • Never keep out of date or unwanted medicines. Take them to your local pharmacy which will dispose of them for you.
  • If you have any questions about this medicine ask your pharmacist.

References

Comprehensive patient resources are available at www.patient.co.uk
© EMIS 2011DocID: 3567DocRef: dils3007Last Reviewed: 19 Oct 2011Version: 24
For the planned review period see the Data Creation and Quality Control Process.
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