Tioguanine

  • Take tioguanine exactly as directed. Your doctor will tell you how many tablets to take each day and for how long.
  • You will need regular blood tests including blood cell counts and weekly liver function tests.
  • You will have an increased risk of infection while you are taking tioguanine - let your doctor know straight away if you develop a fever, sore throat, or if you generally feel unwell.
Type of medicine Antimetabolite
Used for Leukaemia (blood cancer)
Also called Lanvis®
Available as Tablets

Cancers form when some cells within the body multiply uncontrollably and abnormally. These cells then spread and destroy nearby tissues. Tioguanine works by preventing the growth and dividing of cancer cells.

Before taking tioguanine make sure your doctor or pharmacist knows:

  • If you are pregnant, trying for a baby or breast-feeding.
  • If you suffer from liver or kidney problems.
  • If you know you have a deficiency of the enzyme thiopurine methyltransferase.
  • If you are taking other medicines, including those available to buy without a prescription, herbal and complementary medicines.
  • If you have ever had an allergic reaction to this or any other medicine.
  • Before starting this treatment, read the manufacturer's printed information leaflet from inside the pack.
  • You will be prescribed tioguanine by a specialist doctor experienced in treating blood problems.
  • Follow the instructions you have been given and take tioguanine exactly as your doctor has told you. Your dose will depend on what other treatment you are on.
  • Swallow the tablets with a drink of water. If you need to touch any broken tablets, wash your hands well afterwards.
  • If you forget to take a dose, contact your doctor or clinic for advice.
  • Keep your regular appointments with your doctor so your progress can be monitored.
  • You will need to have regular blood tests during this treatment including blood cell counts and weekly liver function tests.
  • It is important that you do not become pregnant or father a child while you are taking tioguanine. If this affects you, make sure you use effective contraception.
  • While you are taking tioguanine, and for a while after you stop treatment, do not have any vaccinations without talking to your doctor first. Tioguanine will lower your body's resistance and there is a chance that you may get an infection from the vaccine.
  • If you are having an operation or dental treatment, tell the person carrying out the treatment that you are taking tioguanine.
  • If you buy any medicines, check with a pharmacist that they are safe to take with your other medicines.

Your doctor will have discussed with you the possibility of unwanted side-effects of treatment with tioguanine. Let your doctor know if you experience any of the following:

Common side-effects What can I do if I experience this
Inflammation of the mouth Avoid citrus fruit/drink and take extra care while brushing teeth
Feeling or being sick Eat little and often. Stick to simple or bland foods
Jaundice, unexplained bruising or bleeding, infections It is important that you let your doctor know about these straight away
  • Keep all medicines out of the reach and sight of children.
  • Store in a cool, dry place, away from direct heat and light.
  • Do not keep any unwanted tablets. Take them to your local pharmacy which will dispose of them for you.

  • Never take more than the prescribed dose. If you suspect that you or someone else has taken an overdose of this medicine go to the accident and emergency department of your local hospital at once. Take the container with you, even if it is empty.
  • This medicine is for you. Never give it to other people even if their condition appears to be the same as yours.
  • If you have any questions about this medicine ask your pharmacist.

Further reading & references

  • British National Formulary; 60th Edition (September 2010) British Medical Association and Royal Pharmaceutical Society of Great Britain, London.
  • Manufacturer's PIL, LanvisĀ® Tablets; Manufacturer's PIL, LanvisĀ® Tablets, Aspen Europe GmbH, electronic Medicines Compendium. Dated September 2008.
Original Author: Helen Allen Current Version:
Last Checked: 20/04/2011 Document ID: 1503  Version: 23 © EMIS

Disclaimer: This article is for information only and should not be used for the diagnosis or treatment of medical conditions. EMIS has used all reasonable care in compiling the information but make no warranty as to its accuracy. Consult a doctor or other health care professional for diagnosis and treatment of medical conditions. For details see our conditions.

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