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Spironolactone

  • Spironolactone is known as a water tablet and will make you want to urinate more often.
  • Take your dose in the morning after food.

About spironolactone

Type of medicineAldosterone antagonist diuretic
Used forOedema (water retention)
Ascites (too much fluid in the abdomen)
Heart failure (a condition where the pumping action of the heart is reduced)
Primary aldosteronism (extra fluid in your body caused by too much of a hormone called 'aldosterone')
Also calledAldactone®
Available asTablets

Diuretics are often referred to as water tablets. Spironolactone is known as a potassium-sparing diuretic because, unlike some other diuretics, it does not cause your body to lose potassium.

Spironolactone is used to treat oedema (too much fluid causing swelling), often caused by liver disease, kidney problems or heart failure. It prevents the build-up of fluid by increasing the amount of urine produced by the kidneys. It can also be used for other problems caused by too much fluid in the body, such as primary hyperaldosteronism.

Before taking spironolactone

Before taking spironolactone make sure your doctor or pharmacist knows:

  • If you are pregnant, trying for a baby or breast-feeding.
  • If you have liver or kidney problems.
  • If you have Addison's disease (a disorder of the adrenal glands).
  • If you have porphyria (a blood disorder).
  • If you know you have high levels of potassium or low levels of sodium in your blood.
  • If you are taking other medicines, including those available to buy without a prescription, herbal or complementary medicines.
  • If you have ever had an allergic reaction to this or any other medicine.

How to take spironolactone

  • Before beginning treatment, read the manufacturer's printed information leaflet.
  • Take spironolactone exactly as directed by your doctor. Take your dose with or after food.
  • Try to take spironolactone at the same time each day to avoid missing any doses. It will make you want to go to the toilet more often so your doctor will usually advise you to take your dose in the morning.
  • If you forget to take a dose, take it as soon as you remember. However, if it is after 6 pm in the evening, skip the missed dose and continue taking it at the usual times. Do not take two doses at the same time to make up for a missed dose.

Getting the most from your treatment

  • Diuretics help you to lose water. On occasions you may lose too much and become dehydrated, leaving you feeling thirsty and your skin looking and feeling dry. Let your doctor know if this happens.
  • A diet rich in potassium should be avoided whilst taking this medicine as too much potassium can be harmful. Your doctor or pharmacist will be able to advise you on your diet. Salt substitutes also contain potassium. Do not use them while taking spironolactone unless you have been instructed to do so by your doctor.
  • If you are having any treatment like an operation or dental treatment, tell the person carrying out the treatment which medicines you are taking.
  • Keep your regular doctor's appointment so that your progress can be monitored.
  • Do not stop taking spironolactone without speaking to your doctor first, even if you feel well.
  • If you buy any medicines, check with a pharmacist that they are safe to take with your other medicines.

Can spironolactone cause problems?

Along with their useful effects all medicines can cause unwanted side-effects. These usually improve as your body adjusts to the new medicine. Speak with your doctor or pharmacist if any of the following side-effects continue or become troublesome.

Common side-effects - these affect less than 1 in 10 people who take this medicineWhat can I do if I experience this
Feeling or being sickEat little and often. Stick to simple foods
HeadacheAsk your pharmacist to recommend a suitable painkilller. If the headache continues, speak with your doctor
TirednessMake sure your reactions are normal before driving, operating machinery or doing any other jobs which would be dangerous if you were not fully alert
Sexual problems, enlargement of the breasts (in both men and women), irregular menstrual periods, confusion and skin rashIf any of these become troublesome, speak with your doctor

If you experience any other symptoms which you think may be due to this medicine, speak with your doctor or pharmacist.

How to store spironolactone

  • Keep all medicines out of the reach and sight of children.
  • Store in a cool, dry place, away from direct heat and light.

Important information about all medicines


  • Never take more than the prescribed dose. If you suspect that you or someone else has taken an overdose of this medicine, go to the accident and emergency department of your local hospital at once. Take the container with you, even if it is empty.
  • This medicine is for you. Never give it to other people even if their condition appears to be the same as yours.
  • Never keep out-of-date or unwanted medicines. Take them to your local pharmacy which will dispose of them for you.
  • If you have any questions about this medicine ask your pharmacist.

References

Comprehensive patient resources are available at www.patient.co.uk
© EMIS 2010DocID: 3360DocRef: dils2365Last Reviewed: 22 Mar 2010Version: 22
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