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Primidone
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About primidone
| Type of medicine | Antiepileptic |
| Used for | Epilepsy Essential tremor (uncontrollable shaking usually of the hands) |
| Also called | Mysoline® |
| Available as | Tablets |
Primidone controls the convulsions (fits or seizures) in some forms of epilepsy by reducing the activity in the brain. It is also sometimes used to prevent essential tremor which is a condition in which there is uncontrollable shaking, usually of the hands.
Before taking primidone
Before taking primidone make sure your doctor or pharmacist knows:
- If you are pregnant, trying for a baby or breast-feeding.
- If you have liver or kidney problems.
- If you have breathing problems.
- If you have porphyria (a blood disorder).
- If you have had any problems with drug or alcohol dependence.
- If you are taking other medicines, including those available to buy without a prescription, herbal or complementary medicines.
- If you have ever had an allergic reaction to this or any other medicine.
How to take primidone
- Before beginning treatment, read the manufacturer's printed information leaflet.
- Take primidone exactly as directed by your doctor. It is usually taken twice a day although it may also be taken just once a day at bedtime. Your doctor will tell you which is right for you.
- Your dose of primidone will be increased slowly over the first few weeks of treatment and you may need to have blood tests to make sure the dose you are receiving is right for you.
- Try to take primidone at the same times each day to avoid missing any doses.
- If you forget to take a dose, take one as soon as you remember unless it is time for your next dose in which case skip the missed dose. Do not take two doses at the same time to make up.
Getting the most from your treatment
- If you are having any treatment like an operation or dental treatment, tell the person carrying out the treatment which medicines you are taking.
- You must keep your regular appointments with your doctor or hospital so your progress can be checked.
- Primidone may cause drowsiness. You are advised not to drink alcohol while you are taking primidone as it may increase these feelings of drowsiness.
- People with epilepsy must stop driving. Your doctor will advise you about when it may be possible for you to resume driving again. This will usually be after a year free of seizures.
- Do not stop taking this medicine without speaking to your doctor first. Your doctor will want to reduce your dose very gradually as stopping suddenly can cause problems.
- If you buy any medicines, check with a pharmacist that they are safe to take with primidone.
Can primidone cause problems?
Along with their useful effects all medicines can cause unwanted side effects which usually improve as your body adjusts to the new medicine. Speak with your doctor or pharmacist if any of the following side effects continue or become troublesome.
| Common side-effects - these affect less than 1 in 10 people who take this medicine | What can I do if I experience this |
| Light-headedness, unsteadiness | Getting up or moving more slowly should help. If you begin to feel dizzy, lie down for a few moments before sitting or standing. If this continues let your doctor know |
| Drowsiness, weakness | Make sure your reactions are normal before doing any jobs that could be dangerous if you were not fully alert |
| Feeling sick | Eat little and often. Stick to simple foods |
| Shortness of breath, visual changes, behaviour changes, mood changes (such as irritability, confusion, excitement or depression), hearing or seeing things that are not real, and skin rashes | If any of these become troublesome, speak to your doctor |
Important: If you develop any of the following speak with your doctor immediately or go to your local accident and emergency department:
- a severe skin reaction which includes redness, ulcers and blistering,
- fever, a sore throat, abnormal paleness or unexplained bruising or bleeding.
If you experience any other symptoms which you think may be due to this medicine, speak with your doctor or pharmacist.
How to store primidone
- Keep all medicines out of the reach and sight of children.
- Store in a cool, dry place, away from direct heat and light.
Important information about all medicines
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References
- Manufacturer's PIL, Mysoline®, Acorus Therapeutics Limited, electronic Medicines Compendium. Dated April 2009, accessed May 2009.
- British National Formulary; 57th Edition (March 2009) British Medical Association and Royal Pharmaceutical Society of Great Britain, London (link to current BNF).
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The authors and editors of this article are employed to create accurate and up to date content reflecting reliable research evidence, guidance and best clinical practice. They are free from any commercial conflicts of interest. Find out more about updating.
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