Phenoxybenzamine

  • Keep your regular appointments with your doctor so that your progress can be checked.
  • Do not stop taking phenoxybenzamine without consulting your doctor first.
  • Side-effects of treatment may include dizziness, light-headedness, a racing heartbeat and tiredness.

About phenoxybenzamine

Type of medicineAlpha-adrenoceptor blocker
Used forHigh blood pressure caused by a disease called phaeochromocytoma
Also calledDibenyline®
Available asCapsules and injection

Phaeochromocytoma is a tumour of the inner part of the adrenal gland. In phaeochromocytoma, high blood pressure is caused by the release of chemicals from the adrenal gland which constrict blood vessels. Phenoxybenzamine works by blocking the sites (known as alpha-receptors) on the blood vessels where these chemicals work and this blocking action reduces the high blood pressure which is associated with the disease.

Before taking phenoxybenzamine

Before taking phenoxybenzamine make sure your doctor or pharmacist knows:

  • If you are pregnant, trying for a baby or breast-feeding.
  • If you suffer from kidney problems.
  • If you have heart disease or if you have recently had a heart attack.
  • If you have ever had a stroke.
  • If you suffer from porphyria (a rare blood disorder).
  • If you have ever had an allergic reaction to this or any other medicine.
  • If you are taking any other medicines, including those available to buy without a prescription, herbal and complementary medicines.

How to take phenoxybenzamine

  • Before beginning treatment, read the manufacturer's printed information leaflet.
  • Take phenoxybenzamine capsules exactly as your doctor has told you to. Your dose may increase over the first few days.
  • Try to take your doses at the same times each day to avoid missing any.

Getting the most from your treatment

  • Keep your regular appointments with your doctor so that your progress can be checked.
  • Do not stop taking phenoxybenzamine without consulting your doctor first.
  • Before buying any medicines, check with your pharmacist which medicines are safe for you to take alongside phenoxybenzamine.
  • Phenoxybenzamine may cause you to become tired, dizzy or less alert than you normally are. This is most likely to happen at the start of treatment. Make sure you know how you react to this medicine before you drive, operate machinery or do any other job that could be dangerous if you were not fully alert.

Can phenoxybenzamine cause problems

Along with their useful effects all medicines can cause unwanted side effects, which usually improve as your body adjusts to the new medicine. Speak with your doctor or pharmacist if any of the following side effects continue or become troublesome.

Common side-effects - these affect less than 1 in 10 people who take this medicineWhat can I do if I experience this
Dizziness, light-headedness or fainting, especially when getting up from a lying or sitting positionGetting up slowly may help. If you begin to feel dizzy, lie down so that you do not faint, then sit for a few moments before standing
Tiredness, nasal stuffiness, eyesight problems, ejaculatory problems, a racing heartbeatIf any of these are troublesome, speak with your doctor

If you experience any other symptoms which you think may be due to this medicine, speak with your doctor or pharmacist.

How to store phenoxybenzamine

  • Keep all medicines out of the reach and sight of children.
  • Store in a cool, dry place, away from direct heat and light.

Important information about all medicines


  • Make sure that the person prescribing this medicine knows about any other medicines that you are taking. This includes medicines you buy and herbal and homeopathic medicines.
  • If you buy any medicines check with a pharmacist that they are safe to take with your other medicines.
  • Before taking this medicine tell your doctor if you have ever had an allergic reaction after taking any medicine.
  • Never take more than the prescribed dose. If you suspect that you or someone else has taken an overdose of this medicine go to the accident and emergency department of your local hospital at once. Take the container with you, even if it is empty.
  • If you are having any treatment like an operation or dental treatment tell the person carrying out the treatment which medicines you are taking.
  • This medicine is for you. Never give it to other people even if their condition appears to be the same as yours.
  • Never keep out of date or unwanted medicines. Take them to your local pharmacy which will dispose of them for you.
  • If you have any questions about this medicine ask your pharmacist.

References

  • British National Formulary; 56th Edition (September 2008) British Medical Association and Royal Pharmaceutical Society of Great Britain, London (link to current BNF).
Comprehensive patient resources are available at www.patient.co.uk
© EMIS 2008DocID: 1459DocRef: dils2234Last Reviewed: 15 Dec 2008Version: 22
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