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Perphenazine


  • Swallow perphenazine tablets with a drink of water. Do not take antacids or indigestion remedies at the same time.
  • Perphenazine may cause drowsiness.
  • Do not drink alcohol while you are taking perphenazine.

About perphenazine

Type of medicinePhenothiazine antipsychotic
Used forSchizophrenia and other mental health problems
Anxiety
Agitation
Treatment of nausea and vomiting
Also calledFentazin®
Triptafen® (perphenazine with amitriptyline)
Available asTablets

Perphenazine belongs to a group of medicines called phenothiazines and is thought to work by blocking the effects of a chemical in the brain called dopamine. It is used in schizophrenia (a mental illness with symptoms such as hearing, seeing or sensing things that are not real) and to help in the short-term management of anxiety or agitation.

Perphenazine can also be used to treat conditions not associated with mental health problems, such as feeling or being sick.

Before taking perphenazine

Before taking perphenazine make sure your doctor or pharmacist knows:

  • If you are pregnant, trying for a baby or breast-feeding.
  • If you are over 65 years of age.
  • If you have heart or breathing problems.
  • If you have liver, kidney or prostate problems.
  • If you have a blood disorder.
  • If you suffer from Parkinson's disease, epilepsy, glaucoma, or depression.
  • If you have ever had jaundice.
  • If you have an underactive thyroid gland.
  • If you have myasthenia gravis (a condition causing muscle weakness) or phaeochromocytoma (a growth on the adrenal glands).
  • If you have ever had an allergic reaction to this or any other medicine.
  • If you are taking any other medicines, including those available to buy without a prescription, herbal and complementary medicines.

How to take perphenazine

  • Before starting this treatment, read the manufacturer's printed information leaflet from inside the pack.
  • Take perphenazine exactly as your doctor has told you.
  • Swallow the tablets with a drink of water. Do not take an antacid or indigestion remedy at the same time as taking perphenazine.
  • Try to take perphenazine at the same times each day to avoid missing any doses.
  • If you forget to take a dose, take it as soon as you remember unless it is nearly time for your next dose, in which case leave out the missed dose. Do not take two doses together to make up for a forgotten dose.

Getting the most from your treatment

  • Keep your doctor's appointments so that your progress can be monitored. Your doctor will want to review this treatment regularly.
  • Perphenazine may cause drowsiness. Do not drink alcohol while you are taking perphenazine as it could increase these feelings of drowsiness.
  • If you have been taking perphenazine for more than a year or so, stopping treatment suddenly can cause problems and your doctor will probably want you to reduce your dose gradually if this is necessary.
  • If you buy any medicines, check with a pharmacist that they are safe to take with perphenazine.
  • Perphenazine may cause your skin to become more sensitive to sunlight. Use a sunscreen that protects against UVA light and has a sun protection factor (SPF) of at least 15, especially in strong sunlight or until you know how your skin reacts. Do not use sunbeds.

Can perphenazine cause problems?

Along with their useful effects, most medicines can cause unwanted side-effects although not everyone experiences them. These usually improve as your body adjusts to the new medicine, but speak with your doctor or pharmacist if any of the following side-effects continue or become troublesome.

Common side-effectsWhat can I do if I experience this
Drowsiness, dizziness, blurred visionMake sure your reactions are normal before driving, operating machinery or doing any other jobs which could be dangerous if you were not fully alert or able to see properly
HeadacheAsk your pharmacist to recommend a suitable painkiller. If headache continues speak with your doctor
ConstipationTry to eat a well balanced diet containing plenty of fibre and drink 6-8 glasses of water each day. If constipation continues to be a problem speak with your pharmacist or doctor
Dry mouthTry chewing sugar-free gum or sweets
Shakiness, abnormal face and body movements, restlessness, uncontrollable movements of the tongue, face and jaw, mood changes, trouble sleeping, confusion, and problems passing urineSpeak with your doctor as soon as possible if you suffer from any of these problems

Important: If you experience 'flu-like' symptoms such as muscle stiffness, high temperature, abnormal paleness, sweating, a very fast heartbeat, extreme drowsiness or confusion, then contact your doctor or go to the accident and emergency department of your local hospital immediately.

How to store perphenazine

  • Keep all medicines out of the reach and sight of children.
  • Store in a cool, dry place, away from direct heat and light.

Important information about all medicines


  • Never take more than the prescribed dose. If you suspect that you or someone else has taken an overdose of this medicine go to the accident and emergency department of your local hospital at once. Take the container with you, even if it is empty.
  • If you are having an operation or any dental treatment, tell the person carrying out the treatment which medicines you are taking.
  • This medicine is for you. Never give it to other people even if their condition appears to be the same as yours.
  • Never keep out of date or unwanted medicines. Take them to your local pharmacy which will dispose of them for you.
  • If you have any questions about this medicine ask your pharmacist.

References

Comprehensive patient resources are available at www.patient.co.uk
© EMIS 2011DocID: 1457DocRef: dils2821Last Reviewed: 15 Feb 2011Version: 23
For the planned review period see the Data Creation and Quality Control Process.
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