Oxycodone

  • Oxycodone is used to treat severe pain in adults.
  • Sickness or constipation may occur with this medicine. Your doctor may be able to prescribe medicines to take with oxycodone to help with these side-effects.
  • Oxycodone can also cause drowsiness.
Type of medicine Opioid analgesic
Used for Severe pain in adults, particularly cancer pain or after surgery
Also called OxyContin®
OxyNorm®
Targinact® (contains oxycodone with naloxone)
Available as Capsules, modified-release tablets, oral liquid form, concentrated oral liquid, and injection

Oxycodone is used to relieve severe pain. It works on the nerves and brain to reduce the pain you feel.

Oxycodone is sometimes used in combination with a medicine called naloxone. Naloxone helps to reduce some of the side-effects of oxycodone such as constipation.

Before taking oxycodone make sure your doctor or pharmacist knows:

  • If you are pregnant, trying for a baby or breast-feeding.
  • If you have liver, kidney or prostate problems.
  • If you have breathing problems, such as asthma.
  • If you have low blood pressure.
  • If you have thyroid problems.
  • If you have a convulsive disorder such as epilepsy.
  • If you have a problem in your bile duct.
  • If you have been constipated for more than a week, or have an inflammatory bowel problem.
  • If you have ever had a problem with drug addiction or toxic psychosis (a mental health problem).
  • If you have an adrenal gland problem.
  • If you have cor pulmonale (a heart problem after long-term lung disease).
  • If you have myasthenia gravis (a muscle weakening disorder).
  • If you have porphyria (a rare blood disorder).
  • If you have recently suffered a serious head injury.
  • If you have ever had an allergic reaction to this or to any other medicine.
  • If you are taking any other medicines, including those available to buy without a prescription, herbal and complementary medicines.
  • Take oxycodone exactly as you have been directed by your doctor.
  • If you are taking the modified-release tablets (OxyContin® or Targinact®), these release oxycodone slowly to give a more even effect. Swallow these tablets whole, do not crush or chew them.
  • Before taking oxycodone, read the manufacturer's printed information leaflet.
  • You are advised not to drink alcohol with oxycodone. Taking oxycodone and alcohol will increase the chance you experience the side-effects of dizziness and drowsiness.
  • If you are having any treatment like an operation or dental treatment, tell the person carrying out the treatment that you are taking oxycodone.
  • If you buy any medicines, check with a pharmacist that they are safe to take with oxycodone.
  • If you are planning a trip abroad you are advised to carry a letter with you from your doctor because oxycodone is a controlled drug. If you plan to travel for more than 3 months, you must check with the Home Office before you travel as you will need to apply in writing for a licence to take oxycodone with you.
  • Taking oxycodone regularly for a long time can lead to your body becoming dependent on it, which might cause you to feel restless and irritable when you stop taking it. If you are concerned about this, discuss the problem with your doctor or pharmacist.

Along with their useful effects, all medicines can cause unwanted side-effects although not everyone experiences them. These usually improve as your body adjusts to the new medicine, but speak with your doctor or pharmacist if any of the following side-effects become troublesome.

Common oxycodone side-effects - these affect less than 1 in 10 people who take this medicine What can I do if I experience this?
Feeling or being sick, abdominal pain If this continues, your doctor may prescribe a medicine to ease the sickness
Drowsiness, tiredness, difficulties with vision Make sure your reactions are normal before driving, operating machinery or doing any other jobs which could be dangerous if you were not fully alert or able to see clearly
Constipation Try to eat a well balanced diet containing fibre and drink 6-8 glasses of water each day. If this continues your doctor may prescribe a laxative for you
Diarrhoea Drink plenty of water to replace any lost fluids
Dizziness, particularly when getting up from a sitting or lying position Getting up more slowly may help
Dry mouth Try chewing sugar-free gum or sucking sugar-free sweets
Other side-effects include: muscle stiffness, shallow breathing, palpitations, swollen legs or ankles, mood changes, confusion, anxiety, sleep disturbances, headache, sexual difficulties, difficulty passing urine, indigestion, sweating, flushing, rash, and itching If any of these become troublesome, speak with your doctor

If you experience any other symptoms which you think may be due to this medicine, speak with your doctor or pharmacist.

  • Keep all medicines out of the reach and sight of children.
  • Store in a cool, dry place, away from direct heat and light.

  • Never take more than the prescribed dose. If you suspect that you or someone else has taken an overdose of this medicine go to the accident and emergency department of your local hospital at once. Take the container with you, even if it is empty.
  • This medicine is for you. Never give it to other people even if their condition appears to be the same as yours.
  • Never keep out-of-date or unwanted medicines. Take them to your local pharmacy which will dispose of them for you.
  • If you have any questions about this medicine ask your pharmacist.

Further reading & references

  • British National Formulary; 59th Edition (March 2010) British Medical Association and Royal Pharmaceutical Society of Great Britain, London.
  • Manufacturer's PIL, OxyNorm® 5, 10, 20 mg; Manufacturer's PIL, OxyNorm® 5, 10, 20 mg, Napp Pharmaceuticals Limited, electronic Medicines Compendium. Dated July 2010.
  • Manufacturer's PIL, OxyNorm® liquid; Manufacturer's PIL, OxyNorm® liquid, Napp Pharmaceuticals Limited, electronic Medicines Compendium. Dated July 2010.
  • Manufacturer's PIL, OxyContin® tablets; Manufacturer's PIL, OxyContin® tablets, Napp Pharmaceuticals Limited, electronic Medicines Compendium. Dated August 2010.
Original Author: Helen Allen Current Version: Peer Reviewer: Prof Cathy Jackson
Last Checked: 19/01/2012 Document ID: 1441  Version: 24 © EMIS

Disclaimer: This article is for information only and should not be used for the diagnosis or treatment of medical conditions. EMIS has used all reasonable care in compiling the information but make no warranty as to its accuracy. Consult a doctor or other health care professional for diagnosis and treatment of medical conditions. For details see our conditions.

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