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Mesalazine rectal

  • This belongs to the group of medical products known as aminosalicylates.
  • Mesalazine rectal is used to treat the symptoms of ulcerative colitis.
  • Do not swallow mesalazine rectal. It should be inserted into the rectum (back passage).

About mesalazine rectal

Type of medicineAminosalicylate
Used forTreatment and prevention of ulcerative colitis
Also calledAsacol®, Pentasa®, Salofalk®
Available asSuppositories
Retention enema
Foam enema
Rectal foam

Mesalazine rectal works by reducing inflammation of the large bowel and rectum (back passage).
Ulcerative colitis is a disease that causes inflammation and swelling of the large intestine which leads to problems such as stomach pain and diarrhoea. Mesalazine rectal can also be used to help prevent recurrence of the disease once the symptoms are under control.

Before using mesalazine rectal

Before using mesalazine rectal make sure your doctor or pharmacist knows:

  • If you are pregnant, trying for a baby or breast-feeding.
  • If you suffer from kidney or liver problems.
  • If you have ever had an allergic reaction to aspirin, salicylates or any other medicine.
  • If you are taking or using any other medicines, including those available to buy without a prescription, herbal and complementary medicines.

How to use mesalasine rectal

Wash your hands before and after using your medication.

How to use mesalazine suppositories

  1. You should go to the toilet to empty your bowels and bladder (if necessary) before inserting the suppository.
  2. If the suppository is too soft, it may be cooled in the refrigerator or under cold running water before unwrapping.
  3. Remove the wrapping and moisten the suppository with water. Lie on your left side (if you are right handed) and draw your knees up towards your chest, with the right leg drawn up more than the left.
  4. Using your first finger or middle finger (whichever you find easiest), gently push the suppository into the rectum (back passage), pointed end first.
  5. The suppository should be inserted as far as possible, pushing the end of the suppository sideways to ensure contact with the wall of the bowel.
  6. Lower your legs to a comfortable position to help you to hold the suppository in place.

How to use mesalazine liquid enema

  1. Lie on your left side (if you are right handed) and draw your knees up towards your chest, with the right leg drawn up more than the left.
  2. Remove the top from the enema.
  3. Insert the tube into the rectum (back passage) as far as the mark on the nozzle.
  4. Empty the contents completely by squeezing the tube between the index finger and thumb.
  5. When the tube is empty, remove it from the rectum and throw away.
  6. After using the dose, lower your legs to a comfortable position to help hold the medicine in place.

How to use mesalazine foam enema

  1. Shake the canister vigorously to mix the contents.
  2. If you are using this preparation for the first time you will need to remove the safety tag from just underneath the dome (on the top of the container).
  3. Push the applicator firmly on to the nozzle of the canister.
  4. Standing up, place one foot on to a firm surface, such as a chair.
  5. Hold the canister upside down (with the dome facing down) in the palm of your hand.
  6. Insert the applicator in to the rectum (back passage) as far as it will go comfortably.
  7. Push the dome once and release. If you have been instructed to administer two doses, press the dome again and release. The foam is not administered until the dome is released.
  8. Remove applicator from your rectum.
  9. Remove the applicator from the canister, place in one of the plastic bags provided and dispose of in a bin.

Getting the most from your treatment

  • Use mesalazine exactly as directed by your doctor.
  • Always read the manufacturer's information leaflet, if possible, before beginning treatment.
  • Mesalazine rectal is for you. Never give it to others, even if their condition appears to be the same as yours.
  • Before taking or using any 'over-the-counter' medicines, check with your pharmacist which medicines are safe for you to use.
  • If your symptoms do not improve or if they become worse, check with your doctor.
  • If you are using mesalazine for a long time, it is important to keep regular appointments with your doctor so that your progress can be checked. Depending on your progress your doctor may decide to do some blood tests.

Can mesalazine rectal cause problems

Along with their useful effects all medicines can cause unwanted side effects, which usually improve as your body adjusts to the new medicine. Speak with your doctor or pharmacist if any of the following side effects continue or become troublesome.

Common side-effects - these affect less than 1 in 10 people who take this medicineWhat can I do if I experience this
Feeling sickEat little and often. Stick to simple foods such as dry toast
Stomach painSpeak to your doctor if this continues
HeadacheAsk your pharmacist to recommend a suitable pain-killer. If headache continues speak to your doctor
DiarrhoeaDrink plenty of water to replace lost fluids

Important: If you experience any unusual bleeding or bruising, a sore throat, fever (high temperature) or a general feeling of being unwell then contact your doctor as soon as possible.

How to store mesalazine rectal

  • Keep all medicines out of the sight and reach of children.
  • Store in a cool, dry place, away from direct heat and light.

Important information about all medicines


  • Keep all medicines out of the sight and reach of children.
  • Make sure that the person prescribing this medicine knows about any other medicines that you are taking and using. This includes medicines you buy and herbal and homeopathic medicines.
  • If you buy any medicines check with a pharmacist that they are safe to take with your other medicines.
  • Before using this medicine tell your doctor if you have ever had an allergic reaction after taking any medicine.
  • Never use more than the prescribed dose. If you suspect that you or someone else has used too much rectal mesalazine or has swallowed some, go to the accident and emergency department of your local hospital at once. Always take the container with you, if possible, even if it is empty.
  • If you are having any treatment like an operation or dental treatment tell the person carrying out the treatment which medicines you are taking and using.
  • Always read the printed information leaflet that comes with your medicine.
  • This medicine is for you. Never give it to other people even if their condition appears to be the same as yours.
  • Never keep out of date or unwanted medicines. Take them to your local pharmacy which will dispose of them for you.
  • If you have any questions about this medicine ask your pharmacist.

References

Comprehensive patient resources are available at www.patient.co.uk
© EMIS 2009DocID: 3517DocRef: dils2863Last Reviewed: 19 Dec 2008Version: 22
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