Mebeverine

  • Mebeverine is helpful for abdominal spasms associated with conditions like irritable bowel syndrome.
  • It can be purchased from a pharmacy by people who have previously been diagnosed by a doctor. If this is the first time you have had these symptoms, you should consult your doctor.
  • Take mebeverine about 20 minutes before you eat a meal.
  • If you develop any new symptoms, or if your symptoms worsen, or if your symptoms have not improved within two weeks, you should see your doctor for further advice.
Type of medicine Antispasmodic
Used for Irritable bowel syndrome
Gastrointestinal muscle cramps
Also called Colofac®, Colofac® MR
Boots Pharmacy IBS Relief
Available as Tablets, modified-release capsules, and oral liquid

Mebeverine is an antispasmodic medicine which is used to relieve muscle cramps in the stomach and intestines. It is particularly useful to help ease the spasm-type pain that may be associated with irritable bowel syndrome and similar conditions. It works by relaxing the intestinal muscles causing the problem.

Before taking mebeverine make sure your doctor or pharmacist knows:

  • If you are under 18 years of age.
  • If you are pregnant or breast-feeding.
  • If you know you have a condition called paralytic ileus (a blockage of your bowel).
  • If you have a condition called porphyria (this is a a rare inherited blood disorder).
  • If you are taking other medicines, including those available to buy without a prescription, herbal and complementary medicines.
  • If you have ever had an allergic reaction to this or to any other medicine.
  • Before starting this treatment, read the manufacturer's printed information leaflet from inside the pack. The leaflet will give you more information about the specific brand and strength of mebeverine you have been given, and any possible side-effects from taking it.
  • Take mebeverine exactly as you have been told. Your doctor or pharmacist will tell you how many doses you should take and how often to take them. This dose information will also be on the label of the pack you have been given.
  • Try to take each of your doses about 20 minutes before you eat a meal.
  • If you have been given mebeverine capsules, you should take one in the morning and one in the evening. Do not chew the capsules as this would spoil the coating which controls how the mebeverine is released. Swallow each dose with a small glassful of water (at least 100 ml).
  • If you forget to take a dose, do not worry, just take the next dose as normal. Do not take two doses together to make up for a forgotten dose.
  • If you have purchased mebeverine for irritable bowel syndrome and you develop any new symptoms, or if your symptoms worsen, or if your symptoms have not improved within two weeks of taking it, you should see your doctor for advice (even if you have previously been diagnosed by your doctor).
  • If you buy any other medicines, check with a pharmacist that they are safe to take with this medicine.

Along with their useful effects, most medicines can cause unwanted side-effects although not everyone experiences them. These usually improve as your body adjusts to the new medicine, but speak with your doctor or pharmacist if any of the following side-effects continue or become troublesome.

Possible mebeverine side-effects What can I do if I experience this?
Swelling of the mouth or face, skin itching and rash These effects are rare but may be a sign that you are allergic to mebeverine. Contact your doctor straightaway or go to the accident and emergency department of your local hospital

If you experience any other symptoms which you think may be due to this medicine, speak with your doctor or pharmacist.

  • Keep all medicines out of the reach and sight of children.
  • Store in a cool, dry place, away from direct heat and light.
  • Never take more than the prescribed dose. If you suspect that someone has taken an overdose of this medicine, go to the accident and emergency department of your local hospital at once. Take the container with you, even if it is empty.
  • If you are having an operation or dental treatment, tell the person carrying out the treatment which medicines you are taking.
  • This medicine is for you. Never give it to other people even if their condition appears to be the same as yours.
  • Never keep out-of-date or unwanted medicines. Take them to your local pharmacy which will dispose of them for you.
  • If you have any questions about this medicine ask your pharmacist.

Further reading & references

  • British National Formulary; 62nd Edition (Sep 2011) British Medical Association and Royal Pharmaceutical Society of Great Britain, London
  • Manufacturer's PIL, Colofac® Tablets 135 mg; Abbott Healthcare Products Limited, The electronic Medicines Compendium. Dated February 2014.
  • Manufacturer's PIL, Colofac® MR; Abbott Healthcare Products Limited, The electronic Medicines Compendium. Dated March 2013.

Disclaimer: This article is for information only and should not be used for the diagnosis or treatment of medical conditions. EMIS has used all reasonable care in compiling the information but make no warranty as to its accuracy. Consult a doctor or other health care professional for diagnosis and treatment of medical conditions. For details see our conditions.

Original Author:
Helen Allen
Current Version:
Peer Reviewer:
Dr Adrian Bonsall
Document ID:
3807 (v25)
Last Checked:
20/02/2012
Next Review:
19/02/2015
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