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Glipizide

  • Take glipizide shortly before a meal (usually breakfast).
  • Remember to follow any advice you have been given about your diet and taking exercise.
  • Make sure you know how to recognise the symptoms of hypoglycaemia (low blood sugar). These include sweating, paleness, headache, faintness and drowsiness.

About glipizide

Type of medicineAntidiabetic - an oral sulphonylurea hypoglycaemic agent
Used forDiabetes mellitus (sugar diabetes)
Also calledMinodiab®
Available asTablets

Glipizide can be used to treat type 2 (non-insulin-dependent) diabetes mellitus.

Insulin is made naturally in the pancreas. It regulates the amount of sugar in the blood. If the body does not make enough insulin to meet its needs, or does not properly use the insulin it makes, this results in the condition called diabetes mellitus (sugar diabetes).

Glipizide works by increasing the amount of insulin the pancreas secretes.

Before taking glipizide

Before taking glipizide make sure your doctor or pharmacist knows:

  • If you are pregnant, trying for a baby or breast-feeding.
  • If you have kidney or liver problems.
  • If you have porphyria (a blood disorder).
  • If you are a type 1 (insulin-dependent) diabetic.
  • If you are taking other medicines, including those available to buy without a prescription, herbal or complementary medicines.
  • If you have ever had an allergic reaction to this or any other medicine.

How to take glipizide

  • Before beginning treatment, read the manufacturer's printed information leaflet.
  • Take your dose exactly as you have been directed by your doctor. This is usually shortly before breakfast or lunch.
  • Try to take glipizide at the same time each day to avoid missing any doses.
  • If you forget to take a dose, take one shortly before your next meal and then continue at the usual times. Do not take two doses together to make up for a missed dose.

Getting the most from your treatment

  • It is important that you follow any dietary and lifestyle advice that you have been given, such as reducing the sugary energy foods you eat and increasing the amount of exercise you take.
  • You must keep your regular appointments with your doctor or diabetic clinic. These are to check on your progress.
  • Your doctor may recommend that you test for sugar in the blood or urine to check your diabetes is being well controlled.
  • Hypoglycaemia (low blood sugar) is likely to occur if you miss a meal, if you exercise more than usual, if you cannot eat because of sickness or if you drink a lot of alcohol. Symptoms of hypoglycaemia (sometimes called 'hypos') include sweating, paleness, headache, faintness or drowsiness. If these occur, drink or eat something containing sugar followed by a starchy snack such as a sandwich, to raise your blood sugar.
  • Drivers should take special care on long journeys. If hypoglycaemia occurs, you should stop in a safe place, switch off the engine, eat or drink something containing sugar, and wait at least fifteen minutes before continuing on your journey. Driving is not permitted when you are unable to recognise the warning signs of a hypoglycaemic attack.
  • Do not stop taking this medicine without speaking to your doctor first.
  • Glipizide may cause your skin to become more sensitive to sunlight than it is usually. Avoid sunbeds and strong sunlight until you know how your skin reacts.
  • If you are having any treatment like an operation or dental treatment, tell the person carrying out the treatment which medicines you are taking.
  • If you buy any medicines, check with a pharmacist that they are safe to take with your other medicines.

Can glipizide cause problems?

Along with their useful effects all medicines can cause unwanted side-effects. These usually improve as your body adjusts to the new medicine. Speak with your doctor or pharmacist if any of the following side-effects continue or become troublesome.

Common glipizide side-effects - these affect less than 1 in 10 people who take this medicineWhat can I do if I experience this?
Feeling or being sickEat little and often and stick to simple foods
ConstipationTry to eat a well-balanced diet containing plenty of fibre and drink 6-8 glasses of water each day
DiarrhoeaDrink plenty of water to replace any lost fluids
Dizziness, drowsiness, blurred vision (particularly at the start of treatment)This should soon improve, but make sure your reactions are normal before driving, operating machinery, or doing any other jobs which could be dangerous if you were not able to see clearly
Sweating, paleness, headache, faintness or drowsiness (these are signs of low blood sugar)Eat something containing sugar such as a biscuit or a sugary drink (not diet) and follow this up with a snack such as a sandwich. Tell your doctor if you notice these symptoms

Important: if you experience jaundice (yellowing of the skin and whites of the eyes), fever, or a severe skin rash, speak with your doctor immediately or go to your local accident and emergency department without delay.

If you experience any other symptoms which you think may be due to this medicine, speak with your doctor or pharmacist.

How to store glipizide

  • Keep all medicines out of the reach and sight of children.
  • Store in a cool, dry place, away from direct heat and light.

Important information about all medicines


  • Never take more than the prescribed dose. If you suspect that you or someone else has taken an overdose of this medicine, go to the accident and emergency department of your local hospital at once. Take the container with you, even if it is empty.
  • This medicine is for you. Never give it to other people even if their condition appears to be the same as yours.
  • Never keep out-of-date or unwanted medicines. Take them to your local pharmacy which will dispose of them for you.
  • If you have any questions about this medicine ask your pharmacist.

References

  • British National Formulary; 58th Edition (September 2009) British Medical Association and Royal Pharmaceutical Society of Great Britain, London.
The pharmacists and clinicians responsible for the production of this document are:
Original Author: Helen Allen
Last Checked: 4 Mar 2010
Current Version: Helen Allen
Document ID: 3223  Version: 23
Peer Reviewer: Dr Adrian Bonsall
© EMIS 2011
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