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Before using fluorouracil cream
Before using fluorouracil cream make sure your doctor or pharmacist knows:
- If you are pregnant, trying for a baby or breast-feeding.
- If you are taking other medicines, including those available to buy without a prescription, herbal or complementary medicines.
- If you have ever had an allergic reaction to this or any other medicine.
How to use fluorouracil cream
- Before beginning treatment, read the manufacturer's printed information leaflet.
- Do not use fluorouracil cream if you are under 18 years of age.
- Use this cream exactly as directed by your doctor.
- Apply a thin layer of cream to the affected area. It is very important that you do not use too much cream and do not apply the cream on open cuts, as this can increase the chance of side-effects.
- Only use fluorouracil cream on your skin. Avoid contact with your eyes and mouth.
- As you use fluorouracil cream, the area of skin you are treating will probably become red and swollen. The top layer of skin will then be lost before it begins to heal.
- Fluorouracil cream is usually used once or twice a day for three to four weeks. Your doctor will tell you if you need to apply a dressing to the treated skin.
- Wash your hands thoroughly after using the cream.
- Try to use fluorouracil cream at the same time each day to avoid missing any doses.
- If you miss a dose, apply the cream as soon as you remember. However if it is nearly time for your next application, just apply this when it is due. Do not increase the amount of cream you use to make up for forgetting.
Getting the most from your treatment
- Keep your regular doctor's appointment so your progress can be monitored.
- Sunlight may increase the effects of fluorouracil. This may result in increased skin reactions. To prevent this you must try to stay out of direct sunlight as much as possible while using the cream and do not use a sunlamp or sun bed.
Can fluorouracil cream cause problems?
Local irritation including itching, redness, a burning sensation, peeling, swelling and inflammation of the skin, may all occur. These effects are normal and show that the cream is working. If any of these effects become severe, discuss them with your doctor who may prescribe another cream to help relieve any discomfort.
Important: If you develop rashes on any untreated areas of skin, begin to feel generally unwell, or if you experience any other symptoms, speak with your doctor as soon as possible.
How to store fluorouracil cream
- Keep all medicines out of the reach and sight of children.
- Store in a cool, dry place, away from direct heat and light.
- Once opened, use the cream within 90 days for 20g and 40g tubes and 28 days for the 5g tube.
Important information about all medicines
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References
- Manufacturer's PIL, Efudix Cream®, Meda Pharmaceuticals, electronic Medicines Compendium. Dated September 2010.
- British National Formulary; 61st Edition (March 2011) British Medical Association and Royal Pharmaceutical Society of Great Britain, London (link to current BNF)