Duloxetine

About duloxetine

Duloxetine works by increasing the amount of the chemicals serotonin and noradrenaline within nerves.

In the brain these chemicals control how we feel and it is thought that low levels can lead to depression and anxiety. By increasing the amount of these chemicals, the mood improves.

In stress urinary incontinence, duloxetine increases the strength of the muscles that control the flow of urine which in turn helps to prevent any leakage.

Before taking duloxetine

Before taking duloxetine make sure your doctor or pharmacist knows:

• If you are pregnant, trying for a baby or breast-feeding.
• If you have liver or kidney problems.
• If you have heart problems or hypertension (raised blood pressure).
• If you have ever suffered from mania (great excitement, hallucinations, difficulty in concentrating or being still).
• If you have ever suffered from fits or convulsions.
• If you have glaucoma or increased eye pressure.
• If you have a bleeding disorder or a tendency to develop bruises.
• If you are under 18 years of age.
• If you are taking other medicines, including those available to buy without a prescription, herbal or complementary medicines.
• If you have taken a monoamine oxidase inhibitor (MAOI) antidepressant within the last two weeks.
• If you have ever had an allergic reaction to this or any other medicine.

How to take duloxetine

• Before beginning treatment, read the manufacturer's printed information leaflet.
• Take your medication exactly as directed by your doctor.
• Swallow your capsule whole with a drink of water.
• Try to take duloxetine at the same times each day to avoid missing any doses.
• If you forget to take a dose, take one as soon as you remember unless it is nearly time for your next dose. Do not take two doses at the same time to make up. If in doubt, speak to your pharmacist or doctor.

Getting the most from your treatment

• You may have to take duloxetine for a few weeks before you feel the full effect.
• It is best not to drink alcohol while you are taking duloxetine. If you do drink alcohol it will increase any feelings of drowsiness.
• Keep your regular doctor's appointment so your progress can be monitored.
• Do not stop taking this medicine without speaking to your doctor first. Your doctor will want to reduce your dose slowly as stopping suddenly can cause problems.
• If you buy any medicines, check with a pharmacist that they are safe to take with duloxetine.
• If you are taking duloxetine for stress urinary incontinence, remember to follow any exercises given to you by your doctor or nurse.

Can duloxetine cause problems?

Along with their useful effects all medicines can cause unwanted side effects, which usually improve as your body adjusts to the new medicine. Speak with your doctor or pharmacist if any of the following side effects continue or become troublesome.

How to store duloxetine

• Keep all medicines out of the reach of children.
• Store in a cool, dry place, away from direct heat and light.

Important information about all medicines