Dabigatran to prevent blood clots

  • Dabigatran is a new type of anticoagulant used to prevent harmful clots occurring in your blood.
  • The main possible side-effect of dabigatran and all anticoagulants is bleeding.
  • If you are prescribed or buy any other medicine then tell your doctor, nurse or pharmacist if you are taking dabigatran.
Type of medicine Anticoagulant
Used for To prevent formation of harmful blood clots for people with a certain type of atrial fibrillation (irregular fast heartbeat). It is usually prescribed when there are likely to be additional benefits of taking dabigatran - reducing the likelihood of damage resulting from these clots, eg in patients who have had a stroke, or have high blood pressure or some forms of heart disease. Dabigatran may also be used for patients having hip or knee surgery.
Also called Pradaxa®
Available as Capsules

Dabigatran works by preventing the blood from clotting as quickly or as effectively as normal. It interferes with chemicals needed to make clots or clotting factors. This means that it can be used to prevent blood clots from forming in veins and arteries - for example, clots in your legs, lungs, brain or heart.

Warfarin is the most commonly used anticoagulant in the UK, and has been used for many years. However, people who take warfarin need to have regular blood tests to measure how quickly their blood clots. This often means that the dose of warfarin can change quite frequently. Dabigatran is a new type of anticoagulant and works in a slightly different way to warfarin. People who take dabigatran do not need to have regular blood tests. However, they still need to have occasional blood tests to make sure their kidneys are working well. In addition, for most people the dose of dabigatran remains the same throughout treatment.

Before taking dabigatran make sure your doctor or pharmacist knows:

  • If you are pregnant, trying for a baby or breast-feeding.
  • If your kidneys do not work well.
  • If you are currently bleeding.
  • If you have problems with your liver.
  • If you have any medical problems that may increase your risk of bleeding.
  • If you are taking antifungal medicines called ketoconazole or itraconazole.
  • If you have had an organ transplant and are taking ciclosporin or tacrolimus to prevent rejection.
  • If you are taking other medicines, including those available to buy without a prescription, herbal or complementary medicines.
  • If you have ever had an allergic reaction to this or to any other medicine.
  • Before beginning treatment, read the manufacturer's printed information leaflet.
  • Take your medication exactly as directed by your doctor. The usual dose is one capsule twice a day. Your dose will also be on the label of your pack.
  • Try to take dabigatran at the same time each day to avoid missing any doses.
  • If you forget to take a dose, you can still take it up to six hours before you are due to take your next dose. If it is less than six hours before you need to take your next dose of dabigatran, do not take your missed dose. Miss this dose out and take your next dose of dabigatran as normal. Do not take two doses at the same time to make up for the missed dose. If in doubt, speak to your pharmacist or doctor.
  • Do not take more doses than your doctor has recommended. If you take more dabigatran than recommended, contact your doctor immediately - you may be at risk of bleeding. If you do have bleeding, you may need treatment with a blood transfusion or surgery.
  • If you are having any treatment like an operation or dental treatment, tell the person carrying out the treatment which medicines you are taking.
  • Keep your regular doctor's appointment so your progress can be monitored.
  • Do not stop taking this medicine without speaking to your doctor first.
  • If you buy any medicines, check with a pharmacist that they are safe to take with your other medicines.

Along with their useful effects all medicines can cause unwanted side-effects, which usually improve as your body adjusts to the new medicine. Speak with your doctor or pharmacist if any of the following side-effects continue or become troublesome.

Common side-effects - these affect less than 1 in 10 people who take this medicine What can I do if I experience this?
Nosebleed Contact your doctor as soon as possible
Bleeding from the penis/vagina or urinary tract Contact your doctor as soon as possible
Bleeding from the stomach or bowel (stools may be bright red or black) Contact your doctor as soon as possible
Feeling sick, belly ache or stomach ache, indigestion See your doctor if this persists
Frequent loose or liquid bowel movements See your doctor if this persists
Unusual laboratory test results on liver function Your doctor will measure this and advise you what to do

Important: if you experience bleeding, speak with your doctor immediately or go to your local accident and emergency department without delay.

If you experience any other symptoms which you think may be due to this medicine, speak with your doctor or pharmacist.

  • Keep all medicines out of the reach and sight of children.
  • Store in a cool, dry place, away from direct heat and light.
  • Never take more than the prescribed dose. If you suspect that someone has taken an overdose of this medicine, go to the accident and emergency department of your local hospital at once. Take the container with you, even if it is empty.
  • This medicine is for you. Never give it to other people even if their condition appears to be the same as yours.
  • Never keep out-of-date or unwanted medicines. Take them to your local pharmacy which will dispose of them for you.
  • If you have any questions about this medicine ask your pharmacist.

Further reading & references

Disclaimer: This article is for information only and should not be used for the diagnosis or treatment of medical conditions. EMIS has used all reasonable care in compiling the information but make no warranty as to its accuracy. Consult a doctor or other health care professional for diagnosis and treatment of medical conditions. For details see our conditions.

Original Author:
Helen Allen
Current Version:
Peer Reviewer:
Prof Cathy Jackson
Document ID:
13867 (v1)
Last Checked:
18/04/2012
Next Review:
18/04/2015
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