Co-triamterzide

  • Co-triamterzide is known as a water tablet and will make you want to go to the toilet more to pass water.
  • Take your dose in the morning or during the day.
  • Co-triamterzide may cause your urine to look slightly blue in some lights - this is harmless.

About co-triamterzide

Type of medicineDiuretic
Used forOedema (water retention)
Hypertension (high blood pressure)
Also calledTriamterene and hydrochlorothiazide
Dyazide®
Available asTablets

Co-triamterzide is a diuretic and is sometimes referred to as a water tablet. It contains two ingredients, triamterene and hydrochlorothiazide.

Co-triamterzide is used to treat oedema (water retention) which can be caused by various conditions, especially disorders of the heart or kidney. Oedema occurs when fluid leaks out of blood vessels causing swelling in the tissues of the lungs, feet or ankles. Co-triamterzide prevents the build-up of fluid in the body by increasing the amount of urine produced by the kidneys.

Co-triamterzide is also used to treat hypertension (high blood pressure). It works by removing excess water from the body which helps to reduce the blood pressure.

Before taking co-triamterzide

Before taking co-triamterzide make sure your doctor or pharmacist knows:

  • If you are pregnant, trying for a baby or breast-feeding.
  • If you have liver or kidney problems.
  • If you have diabetes mellitus (sugar diabetes).
  • If you know you have low blood sodium, or high blood calcium.
  • If you have an adrenal gland disorder or Addison's disease.
  • If you suffer from gout.
  • If you suffer from porphyria (a rare blood disorder) or systemic lupus erythematosus (SLE).
  • If you are taking other medicines, including those available to buy without a prescription, herbal or complementary medicines.
  • If you have ever had an allergic reaction to this or any other medicine.

How to take co-triamterzide

  • Before beginning treatment, read the manufacturer's printed information leaflet.
  • Take co-triamterzide exactly as directed by your doctor.
  • Take co-triamterzide with or immediately after a meal.
  • Co-triamterzide will make you want to go to the toilet more often, so your doctor will usually advise you to take your dose in the morning. If you take more than one dose a day, take the second dose after lunch. Do not take any doses after 6 pm in the evening so your sleep is not disturbed.
  • If you miss a dose of co-triamterzide take it as soon as you remember. However, if it is after 6 pm in the evening, skip the missed dose and continue taking it at the usual times. Do not take two doses at the same time to make up for a missed dose.

Getting the most from your treatment

  • Co-triamterzide may cause your urine to look slightly blue in some lights - this is harmless and nothing to be concerned about.
  • Diuretics help you to lose water. On occasions you may lose too much and become dehydrated, leaving you feeling thirsty and your skin looking and feeling dry. Let your doctor know if this happens.
  • Many patients with high blood pressure do not feel unwell but, left untreated, high blood pressure can harm the heart and arteries and damage blood vessels, resulting in a heart attack, stroke, heart failure or kidney failure. It is important that you take these tablets regularly to help reduce the risk of these.
  • It is important that you follow any dietary advice that you have been given by your doctor or nurse.
  • Do not stop taking co-triamterzide without speaking to your doctor first.
  • If you are having any treatment like an operation or dental treatment, tell the person carrying out the treatment which medicines you are taking.
  • Keep your regular doctor's appointment so your progress can be monitored.
  • If you buy any medicines, check with a pharmacist that they are safe to take with your other medicines.

Can co-triamterzide cause problems?

Along with their useful effects all medicines can cause unwanted side-effects. These usually improve as your body adjusts to the new medicine. Speak with your doctor or pharmacist if any of the following side-effects continue or become troublesome.

Common side-effects - these affect less than 1 in 10 people who take this medicineWhat can I do if I experience this
Feeling or being sick, stomach discomfortEat little and often. Stick to simple foods
Dry mouthTry chewing sugar-free gum or sweets
Dizziness, particularly when getting upGetting up and moving more slowly should help. If you begin to feel dizzy, lie down so that you do not faint, then sit for a few moments before standing
Increased sensitivity to sunlightAvoid bright sunlight and use a sun cream factor 15 or higher until you know how your skin reacts. Do not use sunbeds
Skin rashIf this is severe or troublesome, speak with your doctor

If you experience any other symptoms which you think may be due to this medicine, speak with your doctor or pharmacist.

How to store co-triamterzide

  • Keep all medicines out of the reach and sight of children.
  • Store in a cool, dry place, away from direct heat and light.

Important information about all medicines


  • Never take more than the prescribed dose. If you suspect that you or someone else has taken an overdose of this medicine, go to the accident and emergency department of your local hospital at once. Take the container with you, even if it is empty.
  • This medicine is for you. Never give it to other people even if their condition appears to be the same as yours.
  • Never keep out-of-date or unwanted medicines. Take them to your local pharmacy which will dispose of them for you.
  • If you have any questions about this medicine ask your pharmacist.

References

  • British National Formulary; 58th Edition (September 2009) British Medical Association and Royal Pharmaceutical Society of Great Britain, London (link to current BNF).
Comprehensive patient resources are available at www.patient.co.uk
© EMIS 2010DocID: 3535DocRef: dils2909Last Reviewed: 15 Feb 2010Version: 22
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